Site-directed Conjugation of Single-Stranded DNA to Affinity Proteins: Quantifying the Importance of Conjugation Strategy

Andres Rocha Tapia, Fabrice Abgottspon,Johan Nilvebrant,Per-Ake Nygren, Sarah Duclos Ivetich, Andres Javier Bello Hernandez,Ioanna A. Thanasi,Peter A. Szijj, Ghali Sekkat, Francois M. Cuenot,Vijay Chudasama, Nicola Aceto,Andrew J. deMello,Daniel A. Richards

CHEMICAL SCIENCE（2024）

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摘要

Affinity protein–oligonucleotide conjugates are increasingly being explored as diagnostic and therapeutic tools. Despite growing interest, these probes are typically constructed using outdated, non-selective chemistries, and little has been done to...

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