Glia-enriched cortical organoids implanted in mice capture astrocyte diversity
NATURE BIOTECHNOLOGY(2024)
摘要
The underrepresentation of functional glial cells is a major challenge in brain organoid models. We developed an astroglia-enriched cortical organoid model that allows efficient generation of functional astrocytes and enables the formation of astroglial morphological subclasses with layer-specific gene expression profiles upon transplantation into the mouse brain.
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