The Impact of Infant Bacille Calmette-Guérin Vaccination on the Immunogenicity of Other Vaccines: A Randomized Exploratory Study.

Alexander Maytum, David Porter, Philip de Whalley, Amber Thompson,Emma Plested,Simon Kerridge,Xinxue Liu,Gaby Smits,Fiona van der Klis,Matthew D Snape,Elizabeth Clutterbuck,Andrew J Pollard

The Pediatric infectious disease journal（2024）

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摘要

The effect of the Bacille Calmette-Guérin (BCG) vaccine on the immunogenicity of separately administered serogroup C meningococcal vaccine and other vaccinations was examined in 28 infants randomized to receive BCG at age ≤7 days, at 3 months or after study completion. Immunogenicity of the serogroup C meningococcal vaccine and other routine vaccines might be improved when BCG is administered in early infancy.

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