Artificial intelligence for abnormality detection in high volume neuroimaging: a systematic review and meta-analysis
CoRR(2024)
摘要
Purpose: Most studies evaluating artificial intelligence (AI) models that
detect abnormalities in neuroimaging are either tested on unrepresentative
patient cohorts or are insufficiently well-validated, leading to poor
generalisability to real-world tasks. The aim was to determine the diagnostic
test accuracy and summarise the evidence supporting the use of AI models
performing first-line, high-volume neuroimaging tasks.
Methods: Medline, Embase, Cochrane library and Web of Science were searched
until September 2021 for studies that temporally or externally validated AI
capable of detecting abnormalities in first-line CT or MR neuroimaging. A
bivariate random-effects model was used for meta-analysis where appropriate.
PROSPERO: CRD42021269563.
Results: Only 16 studies were eligible for inclusion. Included studies were
not compromised by unrepresentative datasets or inadequate validation
methodology. Direct comparison with radiologists was available in 4/16 studies.
15/16 had a high risk of bias. Meta-analysis was only suitable for intracranial
haemorrhage detection in CT imaging (10/16 studies), where AI systems had a
pooled sensitivity and specificity 0.90 (95
0.83 - 0.95) respectively. Other AI studies using CT and MRI detected target
conditions other than haemorrhage (2/16), or multiple target conditions (4/16).
Only 3/16 studies implemented AI in clinical pathways, either for pre-read
triage or as post-read discrepancy identifiers.
Conclusion: The paucity of eligible studies reflects that most abnormality
detection AI studies were not adequately validated in representative clinical
cohorts. The few studies describing how abnormality detection AI could impact
patients and clinicians did not explore the full ramifications of clinical
implementation.
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