A fully automatic fiducial detection and correspondence establishing method for online C-arm calibration

Online C-arm calibration with a mobile fiducial cage plays an essential role in various image-guided interventions. However, it is challenging to develop a fully automatic approach, which requires not only an accurate detection of fiducial projections but also a robust 2D–3D correspondence establishment. We propose a novel approach for online C-arm calibration with a mobile fiducial cage. Specifically, a novel mobile calibration cage embedded with 16 fiducials is designed, where the fiducials are arranged to form 4 line patterns with different cross-ratios. Then, an auto-context-based detection network (ADNet) is proposed to perform an accurate and robust detection of 2D projections of those fiducials in acquired C-arm images. Subsequently, we present a cross-ratio consistency-based 2D–3D correspondence establishing method to automatically match the detected 2D fiducial projections with those 3D fiducials, allowing for an accurate online C-arm calibration. We designed and conducted comprehensive experiments to evaluate the proposed approach. For automatic detection of 2D fiducial projections, the proposed ADNet achieved a mean point-to-point distance of 0.65 ± 1.33 pixels. Additionally, the proposed C-arm calibration approach achieved a mean re-projection error of 1.01 ± 0.63 pixels and a mean point-to-line distance of 0.22 ± 0.12 mm. When the proposed C-arm calibration approach was applied to downstream tasks involving landmark and surface model reconstruction, sub-millimeter accuracy was achieved. In summary, we developed a novel approach for online C-arm calibration. Both qualitative and quantitative results of comprehensive experiments demonstrated the accuracy and robustness of the proposed approach. Our approach holds potentials for various image-guided interventions.