Enantioselective Synthesis of Substituted Dihydropyrans by Organocatalyst-Mediated Domino Michael/enolization/acetalization Reactions

A highly enantioselective synthetic method for 3,4-trans-dihydropyrans was developed by the reaction of α-acy β-aryl-substituted acrylonitrile and aldehyde catalyzed by diphenylprolinol silyl ether. This is an asymmetric domino reaction via a catalytic Michael reaction/enolization/acetalization.