Early Post-Operative Events after Urethroplasty in Obese Patients: A Multi-Institutional Retrospective Series

Objective To compare early urethroplasty outcomes in non-obese, obese and morbidly obese patients undergoing urethroplasty for urethral stricture disease. The impact of obesity on outcomes is poorly understood but will be increasingly important as obesity continues to rise. Methods Patients underwent urethroplasty at one of five institutions between January 2016 and December 2020. Obese (BMI 30–39.9, n=72) and morbidly obese (BMI > 40, n=49) patients were compared to normal weight (BMI <25, n = 29) and overweight (BMI 25-29.9, n=51) patients. Demographics, comorbidities, and stricture characteristics were collected. Outcomes including complications, recurrence, and secondary interventions were compared using univariate and multivariate analysis. Results 201 patients (Mean BMI 34.1, Range 18.4-65.2) with mean age 52.2 years (SD=17.2) were analyzed. Median follow-up time was 3.71 months. Obese patients were younger (p=0.008), had more anterior (p<0.001), iatrogenic and LS-associated strictures (p=0.036). 60-day complication rate was 26.3% with no differences between cohorts (p= 0.788). 9.5% of patients had extravasation at catheter removal, 18.9% reported stricture recurrence, and 7.4% required additional interventions. Obese patients had greater estimated blood loss (p=0.001) and length of stay (p=0.001). On multivariate analysis, smoking associated with contrast leak (OR 7.176, 95% CI 1.13-45.5) but not recurrence or need for intervention (p=0.155, 0.927). Conclusions Obese patients in our cohort had more anterior, iatrogenic, and LS-related strictures. However, obesity is not associated with complications, contrast leak, secondary interventions, or recurrence. Obese had higher blood loss and length of stay. Urethroplasty is safe and effective in obese patients.