Low-Dose Aspirin for the Prevention of Preeclampsia in Polycystic Ovary Syndrome：A Retrospective Cohort Study

Abstract Background: We set out to investigate whether low-dose aspirin (LDA) is helpful in avoiding preeclampsia (PE) in polycystic ovary syndrome (PCOS), given that data indicate that these people are more likely to develop PE. Methods: This was a retrospective cohort study of pregnancies with PCOS that delivered between January 1, 2018, and February 10, 2024 in our hospital. Clinical characteristics and obstetrical information were examined in the medical record. Propensity score matching (PSM) was utilized to analyze the association between LDA and PE. Results: The study population consisted of 1522 PCOS pregnancies, 395 were at high risk of PE, including 98 took LDA for preventing PE and 297 who did not take LDA. After the PSM, there was no significant difference between the LDA group and no-LDA group in the risk of PE; Likewise, adverse maternal and neonatal outcomes did not differ between the two groups. None of the subgroup interaction tests were significant for the preventive impact of LDA on PE. Conclusions: There was not enough evidence according to this cohort analysis to suggest that LDA can prevent PE in PCOS patients at high risk of PE.