Supplementary Tables S1-S19 from Circulating microRNA Analysis in a Prospective Co-clinical Trial Identifies MIR652–3p as a Response Biomarker and Driver of Regorafenib Resistance Mechanisms in Colorectal Cancer

Supplementary Table S1. Clinical characteristics of the cohorts used in the circulating biomarker analysis Supplementary Table S2. Cox proportional hazard regression analysis for miRNAs whose deregulation is associated with PFS Supplementary Table S3. Cox proportional hazard regression analysis for miRNAs whose deregulation is associated with OS Supplementary Table S4A. Multivariate Analysis of Factors Affecting Progression Free Survival in the PROSPECT-R Trial Supplementary Table S4B. Multivariate Analysis of Factors Affecting Overall Survival in the PROSPECT-R Trial Supplementary Table S5. Associaiton between MIR652-3p expression and overall response rate (ORR) in the PROSPECT-R Trial Supplementary Table S6. Toxicity, dose reductions and treatment discontinuation Supplementary Table S7. Backward stepwise selection of covariate for the pooled analysis. Supplementary Table S8. MVA prognostic model based on known prognostic features in patients treated with regorafenib. Supplementary Table S9. Comparison between MIR652-3p expression by ISH and by RT-PCR in tissues from patients enrolled in the PROSPECT-R Trial Supplementary Table S10. Response after 8 weeks of treatment according to MIR652-3p ISH score in the PROSPECT-R Trial Supplementary Table S11. Comparison between MIR652-3p expression in tissue versus liquid biopses in tissues from patients enrolled in the PROSPECT-R Trial Supplementary Table S12. Clinical-pathological features of the PDO biobank Table S13. List of deregulated genes in the comparison between treated and untreated EC cells grown in the 1021BL co-culture Table S14. List of deregulated genes in the comparison between EC cells grown in the 1021BL Versus the 1021PD co-culture Table S15. List of deregulated genes in the comparison between treated and untreated CAFs grown in the 1021BL co-culture Table S16. List of deregulated genes in the comparison between treated and untreated PDOs grown in the 1021BL co-culture Table S17. List of deregulated genes in the comparison between PDOs grown in the 1021BL Versus the 1021PD co-culture Table S18. List of deregulated genes in the comparison between CAFs grown in the 1021BL Versus the 1021PD co-culture Table S19. List of deregulated genes in the comparioson between 1021BL MIR623-3p over-expressing PDOs and relative contorls