Early Gastric Cancer with RhoGAP Fusion is Linked to Frequent Nodal Metastasis and a Part of Microtubular–mucocellular Histology

Hiroto Noda,Seiji Sakata,Satoko Baba,Yuki Togashi,Kaoru Nakano,Toshiaki Hirasawa,Izuma Nakayama, Chiina Hata,Manabu Takamatsu,Emiko Sugawara,Noriko Yamamoto,Junko Fujisaki,Souya Nunobe,Katsuhiko Iwakiri,Kengo Takeuchi,Hiroshi Kawachi

Gastric cancer（2024）

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摘要

Gastric cancer with fusion genes involving the Rho GTPase-activating protein domain (RhoGAP-GC) is mainly included in the genomically stable type of The Cancer Genome Atlas classification. Clinical implications and histological characteristics of RhoGAP-GC in the early phase remain unclear. We analyzed 878 consecutive pT1b GCs for RhoGAP and its partner genes using fluorescence in situ hybridization assay. RhoGAP fusion was detected in 57 (6.5

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关键词

RhoGAP,Early gastric cancer,Fusion gene,Lymph node metastasis,Microtubular–mucocellular pattern

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