Highly Sensitive Plasmon-Enhanced Spectroscopic Detection of Peptide-Antibody Interactions

We demonstrate a highly sensitive plasmon-enhanced fluorescence sensor to detect antibodies to Cytomegalovirus (CMV), using their specific interaction with a peptide identified through in silico methods. The results show high promise for sensor miniaturization, ease of spatial multiplexing, high sensitivity, and quick response times. The developments are readily applicable to detect antibodies to range of other viruses (e.g., SARS-CoV-2 virus, Bird and Swine Flu).