Peptide Alkyl Thioester Synthesis from Advanced Thiols and Peptide Hydrazides
The Journal of organic chemistry(2024)
摘要
Peptide alkyl thioesters are versatile reagents in various synthetic applications, commonly generated from peptide hydrazides and thiols. However, a notable limitation is the need for a substantial excess of the thiol reagent, restricting usage to simple thiols. Here, we introduce an adapted procedure that significantly enhances thioester production with just a minimal thiol excess, facilitating the use of advanced thiol nucleophiles.
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