Germanyl triazoles as a platform for CuAAC diversification and chemoselective orthogonal cross-coupling

We report the synthesis of germanyl triazoles formed via a copper-catalysed azide-alkyne cycloaddition (CuAAC) of germanyl alkynes. The reaction is functional group tolerant and compatible with complex molecules. Installation of the Ge moeity enables further diversification of the triazole products, including chemoselective transition metal-catalysed cross-coupling reactions using bifunctional boryl/germyl species.