为人民身体健康提供医疗与护理服务。 开展中医医疗 为人民群众身体健康提供医疗、护理、预防、保健服务 为医学院校学生和成人医科学历教育提供医学教学、临床实习服务 为卫生医疗人员提供继续教育、培训、保健、健康教育服务 开展中医学科研、教学工作 完成上级交办的其他工作
The adenosine monophosphate-activated protein kinase(AMPK)signaling pathway plays a pivotal regulatory role in meta-bolic dysfunction-associated fatty liver disease(MAFLD).Activation of AMPK promotes the nucleocytoplasmic translocation of liver kinase B1(LKB1),downregulates key lipogenic factors sterol regulatory element-binding protein-1c(SREBP-1c)and acetyl-CoA car-boxylase(ACC),thereby inhibiting fatty acid synthesis and promoting oxidation.Activation of the AMPK/mTOR pathway induces autophagy,alleviating hepatic steatosis.The AMPK-SREBP-1c/lipin-1 signaling axis suppresses de novo lipogenesis,while the AMPK/NRF2/HO-1 axis ameliorates MAFLD primarily through antioxidative stress and anti-inflammatory mechanisms.Traditional Chinese medicine(TCM),encompassing active components such aspolysaccharides,polyphenols,terpenoids,flavonoids,nucleosides,and herbal formulations,exerts its therapeutic effects by multi-target and multi-pathway modulation of AMPK-related signaling.This effec-tively improves lipid metabolism,insulin resistance,oxidative stress,inflammation,and gut microbiota dysbiosis,consequently retard-ing MAFLD progression.This review comprehensively explores the pathogenesis of MAFLD through the lens of AMPK and systemati-cally summarizes TCM-based therapeutic strategies targeting this pathway,providing a theoretical foundation and direction for future research and novel drug development.
Objective To observe the effect of acupuncture using back-Shu and front-Mu point combination plus Shaoyang meridian points on bone metabolism in treating osteoporosis patients. Method Seventy-two osteoporosis patients were randomly divided into an observation group（36 cases） and a control group（36 cases）. The control group was given oral Alendronate sodium tablets, and the observation group received additional acupuncture treatment using back-Shu and front-Mu point combination plus Shaoyang meridian points. The bone density indicators, visual analog scale（VAS） score, and the levels of serum N-terminal mid-fragment of osteocalcin（N-MID OC） and β-C-terminal telopeptide of type 1 collagen（β-CTX） were compared before and after the treatment. Result After the intervention,bone density and the serum N-MID OC level increased in both groups（P＜0.05） and were higher in the observation group than in the control group（P＜0.05）. The VAS score and serum β-CTX level dropped after the treatment in the two groups（P＜0.05） and were lower in the observation group than in the control group（P＜0.05）. Conclusion Based on the oral pharmaceutical treatment, acupuncture using the back-Shu and front-Mu point combination plus Shaoyang meridian points can boost bone formation, inhibit bone resorption, strengthen bone density, and improve pain in treating osteoporosis.
