Objective To observe the clinical efficacy of Sheng Tiao Du Ren(ascending and regulating the Governor and Conception Vessels)acupuncture in treating non-acute facial neuritis and explore the possible mechanism.Method A total of 120 patients in the non-acute phase of facial neuritis were recruited as the subjects for this prospective study.They were divided into three groups(ordinary group,Sheng Tiao Du Ren group,and joint group)using the random number table method,with 40 cases in each group.The ordinary group received ordinary acupuncture,the Sheng Tiao Du Ren group was treated with Sheng Tiao Du Ren acupuncture,and the joint group received both ordinary and Sheng Tiao Du Ren acupuncture.The clinical efficacy was compared among the three groups.Before after the treatment,the compound muscle action potentials(CMAP),blink reflex(BR)latency,and facial disability index(FDI)score were observed,and the levels of serum interleukin-10(IL-10),transforming growth factor-β(TGF-β),interleukin-17(IL-17),and interleukin-22(IL-22)were compared.Result The cured and markedly effective rate was higher in the joint group than in the ordinary and Sheng Tiao Du Ren groups(P＜0.05).After the treatment,the joint group had a larger CMAP amplitude compared with the ordinary and Sheng Tiao Du Ren groups(P＜0.05),the BR latency was shorter in the joint group than in the ordinary and Sheng Tiao Du Ren groups(P＜0.05),and the FDI score was higher in the joint group than in the other two groups(P＜0.05).After the intervention,the levels of serum IL-10 and TGF-β were higher in the joint group than in the other two groups(P＜0.05),and the levels of serum IL-17 and IL-22 were lower in the joint group compared with the ordinary and Sheng Tiao Du Ren groups(P＜0.05).Conclusion Based on the ordinary acupuncture treatment,Sheng Tiao Du Ren acupuncture can enhance clinical efficacy,improve facial paralysis symptoms,and boost facial nerve motor function in treating non-acute facial neuritis.The mechanism may be related to regulating the balance of regulatory T cells/helper T cells 17.
Objective To observe the clinical effect of acupuncture on nervous tinnitus of kidney essence deficiency pattern based on Dunhuang Jiu Jing Tu.Method A total of 60 cases of nervous tinnitus of kidney essence deficiency pattern were divided into a treatment group(30 cases)and a control group(30 cases)according to random number table method.The control group was treated with conventional acupuncture,and the treatment group was treated with acupuncture according to Dunhuang Jiu Jing Tu.The tinnitus severity was evaluated before and after treatment,and tinnitus handicap inventory(THI)score and tinnitus visual analog scale(VAS)score were compared between the two groups before and after treatment.The clinical efficacy of the two groups was compared.Result After the treatment,the tinnitus VAS scores and THI scores of both groups decreased(P＜0.05),and they were lower in the treatment group than those in the control group(P＜0.05).The total effective rate of the treatment group was lower than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion Acupuncture based on the Dunhuang Jiu Jing Tu is superior to conventional acupuncture in the treatment of nervous tinnitus of kidney essence deficiency pattern.
Objective To observe and compare the clinical efficacy of acupuncture in a prone position and in a seated position for cervicogenic headache.Method Fifty-six eligible patients with cervicogenic headache were randomized into an observation group and a control group,with 28 cases in each group.The observation group received acupuncture in a prone position,while the control group took a seated position.Before and after the treatment,the two groups were observed using the neck disability index(NDI),range of motion(ROM)score of the cervical spine,and visual analog scale(VAS)score for pain.The clinical efficacy was also compared.Result The NDI,cervical ROM,and VAS scores decreased after the treatment in both groups(P＜0.05)and were lower in the observation group than in the control group(P＜0.05).The observation group had a higher total effective rate than the control group(P＜0.05).Conclusion Acupuncture in a prone position can produce more significant clinical efficacy than seated in treating cervicogenic headache.
Objective To study the effects of electroacupuncture(EA)at Zusanli(ST36)on the mean arterial pressure(MAP),heart rate(HR),lactate(LAC),and blood flow in the abdominal organs of rats with delayed intravenous rehydration after the hemorrhagic shock(HS)and seawater immersion injury.Method Eighty-four SPF-grade male Sprague-Dawley rats were selected and divided into an HS+seawater immersion+delayed intravenous rehydration group(control group)and an HS+seawater immersion+EA at ST36+delayed intravenous rehydration group(EA group).Rapid bloodletting through the right common carotid artery was performed till the blood loss reached 45%of the total blood volume,immediately followed by immersion of the body from 0.5 cm below the xiphoid process in the artificial seawater at(23±1)℃for 30 min.Two hours after seawater immersion,the extracted blood and lactated Ringer's solution twice of the volume of the blood loss were intravenously infused.The EA group received EA at bilateral Zusanli 0.5 h after seawater immersion,while the control group was only fixed without interventions.Changes in the MAP,HR,LAC and abdominal organ blood flow were monitored before blood loss(the baseline),immediately after immersion,and 2 h,5 h,and 24 h after immersion.Result Immediately after immersion,the MAP and HR were significantly lower in both groups than before blood loss(P＜0.01),and the MAP and HR were significantly higher in the EA group than in the control group 2 h after immersion(P＜0.05).The LAC level was significantly higher immediately after immersion than before blood loss in both groups(P＜0.01),and the LAC level was markedly lower in the EA group than in the control group 5 h after immersion(P＜0.05).The blood flow volume in the kidney,liver,and intestinal mucosa decreased significantly in both groups after seawater immersion compared with that before blood loss(P＜0.01).The blood flow volume in the kidney,liver,and intestinal mucosa notably improved in the EA group compared with the control group 2 h after immersion(P＜0.01),and the blood flow in the liver and small intestinal mucosa was still notably larger in the EA group than in the control group 5 h after immersion(P＜0.05).Conclusion EA at Zusanli can significantly increase the MAP and HR,reduce blood LAC level,and improve blood flow in the abdominal organs of the animal model of hemorrhagic shock combined with seawater immersion,thus having certain anti-shock effects on sea warfare injuries.
从《内经》时代至今,随着针灸学研究方法学的更迭,诞生了以经络学说为核心的传统针灸学(包括经典针灸学和经典针灸学的现代化研究两部分)和以神经生物学理论为核心的现代针灸学(还原论和系统论为支撑)两种针灸学体系.不同的针灸学体系,是特定的时空下对疾病的认识和总结,在各自的历史进程中发挥着重要作用.经典针灸学是我国古代劳动人民在生产生活实践中总结出来的,与传统文化相结合的一门用于阐述疾病的病因病机、诊断和防治的古代科学.随着针灸国际化的推进,经典针灸学的现代化研究和现代针灸学开始进入针灸研究的舞台.传统针灸学和现代针灸学对疾病的认识角度不同,不同针灸学体系在新环境下显现出的局限性,推动着针灸学体系的前进与革新.
Objective To observe the clinical efficacy of acupuncture combined with oral administration of Zi Yin Tong Luo Tang in treating cognitive impairment after ischemic stroke and investigate its effects on cerebral hemodynamics and the levels of amyloid β-protein 1-42(Aβ1-42),insulin-like growth factor 1(IGF-1),platelet endothelial cell adhesion molecule-1(PECAM-1),and tau protein.Method Ninety patients with cognitive impairment after ischemic stroke were divided into a joint group and a control group using the random number table method,with 45 cases in each group.The control group took Zi Yin Tong Luo Tang orally,and the joint group received acupuncture combined with oral administration of Zi Yin Tong Luo Tang.The China stroke scale(CSS),Montreal cognitive assessment(MoCA),functional comprehensive assessment(FCA),and modified Barthel index(MBI)scores in the two groups were observed before and after the treatment.The mean blood flow velocity,peak blood flow,and vascular resistance index of cerebral arteries were also monitored before and after the intervention.The levels of pentraxin 3(PTX3),vascular cell adhesion molecule-1(VCAM-1),IGF-1,PECAM-1,Aβ1-42,complement C1q tumor necrosis factor-related protein 9(CTRP9),soluble CD40 ligands(sCD40L),and tau protein were compared before and after the treatment.The clinical efficacy was also compared between the two groups.Result The joint group had a higher total effective rate than the control group(P＜0.05).After the treatment,the MoCA,FCA,and MBI scores were higher in the joint group than in the control group(P＜0.05),and the CSS score was lower in the joint group(P＜0.05).After the intervention,the cerebral artery resistance index was lower in the joint group than in the control group(P＜0.05),and the mean blood flow velocity and peak blood flow were higher in the joint group(P＜0.05).The contents of CTRP9,Aβ1-42,and IGF-1 were higher in the joint group than in the control group after the treatment(P＜0.05),and the VCAM-1,PTX-3,sCD40L,PECAM-1,and tau protein were lower in the joint group(P＜0.05).Conclusion Acupuncture combined with oral Zi Yin Tong Luo Tang can improve neurological function,cognitive function,daily living activities,and cerebral artery hemodynamics in treating patients with cognitive impairment after ischemic stroke,producing more significant efficacy than oral Zi Yin Tong Luo Tang alone.Further,this method can inhibit inflammatory responses and regulate the levels of Aβ1-42,IGF-1,PECAM-1,and tau protein.
Objective To observe the clinical efficacy of medicated thread moxibustion combined with needle pricking in the treatment of sciatica and its effect on serum related inflammatory factors interleukin-6(IL-6),interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)levels.Method A total of 72 sciatica patients were randomly divided into a control group and a combination group,with 36 cases in each group.The patients in the combination group were treated with medicated thread moxibustion combined with needle pricking,and the patients in the control group were treated with oral indomethacin tablets and quick-acting sciatica pills.The clinical efficacy,pain visual analog scale(VAS)score,lumbar function score,and levels of IL-6,IL-1β and TNF-α were observed and compared between the two groups.The incidence of adverse reactions was compared between the two groups.Result The curative rate of the combination group was higher than that of the control group(P＜0.05).Compared with the control group after treatment,the pain VAS score and lumbar spine function score were decreased after treatment in the combination group(P＜0.05).After treatment,the serum levels of IL-6,IL-1β and TNF-α in the combination group were lower than those in the control group(P＜0.05).The incidence of adverse reactions in the combination group was lower than that in the control group(P＜0.05).Conclusion Medicated thread moxibustion combined with needle pricking can effectively relieve sciatica,and the curative effect is better than oral medication,which may be related to the regulation of inflammatory factors IL-6,IL-1β and TNF-α levels,and has fewer adverse reactions.
Objective To observe the clinical efficacy of acupuncture plus auricular point sticking in treating sleep disorders in autism patients guided by the principle of calming and settling the mind.Method Based on a randomized controlled design,64 autism patients with sleep disorders were randomized into an observation group(32 cases)and a control group(32 cases).The control group was treated with psychological and behavioral interventions,while the observation group received additional acupuncture and auricular point sticking treatments.The clinical efficacy was compared between the two groups.Post-treatment changes in the children's sleep habits questionnaire(CSHQ)score and polysomnography parameters were observed.Result After the treatment,the observation group gained improvements in the CSHQ score and polysomnography values(P＜0.05),and the observation group was superior to the control group in comparing the CSHQ score and the total sleep duration,number of arousals,light sleep duration,deep sleep duration,and rapid eye movement duration(P＜0.05).The total effective rate was higher in the observation group than in the control group(P＜0.05).Conclusion Based on the psychological and behavioral interventions,acupuncture plus auricular point sticking guided by the principle of calming and settling the mind can improve sleep quality and enhance clinical efficacy in treating sleep disorders in autism patients.
Objective To observe the clinical efficacy of Tong Du Xing Shen acupuncture combined with repetitive transcranial magnetic stimulation in the treatment of cognitive impairment after stroke and its effect on cognitive function,memory and P300 amplitude.Method Eighty patients with post-stroke cognitive impairment were studied and randomly divided into a control group(39 patients)and an observation group(41 patients).Both groups were treated with cognitive function rehabilitation training.The control group was treated with repetitive transcranial magnetic stimulation,and the observation group was treated with Tong Du Xing Shen acupuncture combined with repetitive transcranial magnetic stimulation.The clinical efficacy of the two groups was compared,and the changes of Montreal cognitive assessment(MoCA)score,Rivermead behavioral memory test-Ⅱ(RBMT-Ⅱ)score,modified Barthel index(MBI)score,and head P300 amplitude and latency were observed before and after treatment.Result The total effective rate of the observation group was higher than that of the control group(P＜0.05).After treatment,the scores of MoCA,RBMT-Ⅱ and MBI and the amplitude of head P300 in the two groups were higher than those before treatment(P＜0.05),and they were higher in the observation group than in the control group(P＜0.05).The P300 latency of the two groups was lower than that before treatment(P＜0.05),and that of the observation group was lower than that of the control group(P＜0.05).Conclusion In addition to the cognitive function rehabilitation training,acupuncture combined with repetitive transcranial magnetic stimulation can effectively improve the cognitive function of patients with post-stroke cognitive impairment,enhance memory,improve the ability of daily living,and increase the amplitude of P300,and the curative effect is better than the treatment of repetitive transcranial magnetic stimulation alone.
Objective To observe the clinical effect of Governor Vessel moxibustion combined with specific exercise correction therapy in the treatment of adolescent idiopathic scoliosis.Method A total of 90 patients with adolescent idiopathic scoliosis were randomly divided into a Governor Vessel moxibustion group,a motion correction group and a combination group,with 30 cases in each group.The Governor Vessel moxibustion group was treated with Governor Vessel moxibustion alone,the exercise correction group was treated with the German Schroth exercise correction method,and the combination group was treated with Governor Vessel moxibustion combined with the German Schroth exercise correction method.After 3 months of treatment,the Cobb angle and the length of seated forward bending were observed in the three groups.The clinical efficacy of the three groups was compared.Result The total effective rate of the combination group was better than that of the Governor Vessel moxibustion group and the exercise correction group,and the difference was statistically significant(P＜0.05).The Cobb angle improved in all three groups after treatment compared with that before treatment(P＜0.05),and the combination group was better than the remaining two groups(P＜0.05).The length of seated forward bending decreased in all three groups after treatment compared with that before treatment(P＜0.05),and the combination group was better than the remaining two groups(P＜0.05).Conclusion Governor Vessel moxibustion combined with exercise correction is effective in correcting the Cobb angle and in reducing the length of seated forward bending in adolescent idiopathic scoliosis,and is more effective than monotherapy.
Objective To observe the effect and safety of chorionic gonadotropin acupoint injection on male late-onset hypogonadism.Method Using randomized controlled methods,40 cases of late-onset gonad hypofunction male patients were randomly divided into an experimental group and a control group,with 20 cases in each group.The experimental group was treated with acupoint injection of chorionic gonadotropin,and the control group was treated with intramuscular injection of chorionic gonadotropin.The aging male symptoms(AMS)score and the International index of erectile function-5(IIEF-5)and international prostate symptom scores(IPSS)were compared between the two groups before and after treatment.The serum testosterone(TT),free testosterone(FT),prostate specific antigen(PSA)and semen parameters(semen volume,sperm concentration,total sperm count,total sperm motility,progressively motile sperm and normal sperm morphology rate)before and after treatment were observed in the two groups.The incidence of adverse reactions in the two groups was observed.Result After treatment,the AMS and IIEF-5 scores,TT and FT levels of the two groups were significantly improved as compared with those before treatment(P＜0.05),and the AMS and IIEF-5 scores of the experimental group were better than those of the control group(P＜0.05).There were no obvious adverse reactions in the two groups.Conclusion Chorionic gonadotropin acupoint injection is superior to chorionic gonadotropin intramuscular injection in improving the AMS and IIEF-5 scores of male patients with late-onset hypogonadism.It can increase the levels of serum TT and FT,without affecting prostate-specific antigen and sperm-related parameters,and has no adverse reactions.
强直性脊柱炎(ankylosing spondylitis, AS)为世界疑难病之一[1],好发于青壮年男性,以关节疼痛、僵硬及活动受限为主要临床表现,多呈上行性发展,先侵犯骶髂关节,逐渐累及脊柱、中轴骨骼及四肢大关节,可伴发关节外表现,导致心、眼、肺、肾、神经系统等病变,严重者可出现脊柱的纤维强直和骨性强直,致残率高[2-4],严重影响患者生活质量,加重患者及其家庭负担.
得气是针刺操作的重要环节,是影响针刺疗效的关键因素之一.研究得气的科学基础、影响因素、激发条件等对于应用和调控得气以及提高针刺疗效具有重要意义.得气是一种针刺感觉,目前的量化评价存在一定主观性,故需要对得气进行客观表征研究.该文对得气的量化评价方法进行了总结,并从穴位局部和大脑中枢反应阐释了得气客观表征的研究现状并进行分析,以期为该领域的研究提供相关参考.
Objective To observe the clinical efficacy of electroacupuncture combined with Qi Shen Huan Wu capsule in the treatment of vascular dementia of intertwined phlegm and blood stasis pattern,and to observe its effect on cognitive function and cerebral hemodynamics.Method Ninety-six patients with vascular dementia of intertwined phlegm and blood stasis pattern were randomly divided into three groups(group A,group B and group C),with 32 cases in each group.Group A was given oral Cytarabine capsule,group B was given Qi Shen Huan Wu capsule in addition to the treatment used in group A,and group C was given electroacupuncture in addition to the treatment used in group B.The clinical efficacy and the occurrence of adverse effects of the three groups were compared.The scores of mini mental state examination(MMSE)and activity of daily living(ADL)were observed before and after the treatment of the three groups.The changes of cerebral hemodynamic indexes(peak systolic and diastolic velocities of the middle cerebral artery)and serum brain damage indexes[central nervous system specific protein β(S-100β)and neuron-specific enolase(NSE)]were observed before and after the treatment of the three groups.Result The total effective rate of group C was 93.8%,which was higher than that of group B(75.0%)and group A(50.0%)(P＜0.05).The total effective rate of group B was higher than that of group A(P＜0.05).After treatment,the differences among the three groups in MMSE and ADL scores,peak systolic and diastolic velocities of the middle cerebral artery,and serum S100β and NSE levels were statistically significant(P＜0.05);MMSE and ADL scores,peak systolic and diastolic velocities of the middle cerebral artery,and serum S100β and NSE levels of group C were superior to those of group A and B(P＜0.05);there was an interaction between time and group effect(P＜0.05).Conclusion In addition to oral administration of Cytarabine capsules,the clinical efficacy of electroacupuncture combined with Qi Shen Huan Wu capsule in the treatment of vascular dementia of intertwined phlegm and blood stasis pattern was better than that of oral administration alone,and it could improve the cognitive function and daily life ability of the patients,as well as improve the haemodynamic indexes of the middle cerebral artery and the level of serum brain damage indexes.
Objective To observe the clinical efficacy of Yi Zhi Kai Qiao(intelligence-benefiting and orifice-opening)acupuncture plus Yi Zhi Tang in treating vascular dementia.Method A total of 104 patients with vascular dementia were randomized into a control group and an observation group,with 52 cases in each group.The control group received oral administration of Yi Zhi Tang,and the observation group received additional Yi Zhi Kai Qiao acupuncture.The clinical efficacy was compared between the two groups.Before and after the treatment,the symptom scores of traditional Chinese medicine(TCM),mini-mental state examination(MMSE)score,Montreal cognitive assessment(MoCA)score,clinical dementia rating(CDR)score,and activities of daily living(ADL)scale score were observed,as well as serum neurotrophins[central nervous system specific protein β(S-100β),neuron-specific enolase(NSE),and nerve growth factor(NGF)]and peak systolic flow velocity(Vp),mean blood flow velocity(Vm),and pulsatility index(PI)of the middle cerebral arteries.Result The total effective rate was 94.2%in the observation group,higher than 82.7%in the control group(P＜0.05).After the treatment,the TCM symptom scores,MMSE score,CDR score,the levels of S-100β and NSE,and middle cerebral artery Vp and Vm decreased in both groups(P＜0.05),and the NGF level,MoCA score,ADL score,and middle cerebral artery PI increased in the two groups(P＜0.05).The observation group was superior to the control group in comparing the above indexes after the intervention(P＜0.05).Conclusion Yi Zhi Kai Qiao acupuncture plus Yi Zhi Tang can produce more significant clinical efficacy than the sole use of Yi Zhi Tang in treating vascular dementia.This method can improve clinical symptoms,enhance daily living activities,and improve cerebral hemodynamics and serum neurotrophin levels.
肢体痉挛是卒中后运动功能障碍的主要表现形式.电针可有效缓解卒中后肢体痉挛,相关机制研究日益深入.该文归纳梳理近几年电针治疗卒中后肢体痉挛领域的相关研究,发现电针可调节脑内相关神经递质、改善突触可塑性、影响脊髓运动神经元兴奋性、影响脑源性神经营养因子-酪氨酸蛋白激酶受体B信号通路信号通路、影响肌肉相关特性、抑制相关炎症表达等.该文综述其相关机制,为电针治疗卒中肢体痉挛提供理论依据,并为进一步相关机制研究提供新思路.
Objective To observe the clinical efficacy and safety of auricular point sticking plus catgut embedding in treating chronic perianal eczema based on perianal block therapy.Method Eighty patients with chronic perianal eczema were divided into an observation group(40 cases,1 dropout)and a control group(40 cases,2 dropouts)using the random number table method.Perianal block therapy with methylene blue mixture was offered to both groups.In addition,the observation group received auricular point sticking plus catgut embedding,and the control group received auricular point sticking.For both groups,the perianal itching intensity score,perianal damp intensity score,perianal skin lesion size and morphology scores,and dermatology life quality index(DLQI)score were observed before and after the treatment.The clinical efficacy,adverse reactions,and recurrence were compared between the two groups.Result After the treatment,the perianal itching intensity score,perianal damp intensity score,perianal skin lesion size and morphology scores,and DLQI score dropped in both groups(P＜0.05)and were lower in the observation group than in the control group(P＜0.05).The observation group had a higher total effective rate than the control group(P＜0.05),and the relapse rate was lower in the observation group than in the control group(P＜0.05).No significant adverse reactions happened during the treatment process in either group.Conclusion Based on perianal block therapy,auricular point sticking plus catgut embedding can relieve perianal itching and dampness,improve perianal skin lesion features,and enhance the quality of life in treating chronic perianal eczema,producing more significant efficacy than the sole use of auricular point sticking with a lower relapse rate.
Objective To discuss the regulatory effect of electroacupuncture(EA)on lacrimal gland cell apoptosis in dry eye rabbits.Method Male New Zealand rabbits were randomly divided into a normal group,a model group,an EA group,and a sham EA group.The dry eye rabbit model was prepared via eye exposure to Benzalkonium chloride solution.The normal group received neither modeling nor interventions.The model group only received the same fixing as the EA group after modeling.The EA and sham EA groups received EA or sham EA interventions,respectively,after modeling.Before and after the intervention,the ocular surface function was examined using the Schirmer Ⅰ test(SⅠT),tear break-up time(TBUT),and corneal fluorescein sodium(CFS)score.The terminal deoxynucleotidyl transferase mediated dUTPnick-end labeling(TUNEL)method was adopted to detect lacrimal gland cell apoptosis,and immunohistochemistry was used to determine the protein expression of Caspase-3,Fas,and Bcl-2 in the lacrimal gland cells.Result Compared with the normal group,the model group rabbits had decreased SⅠT,shortened TBUT,and increased CFS score(P＜0.05),with more serious pathological damage in the lacrimal gland tissues and more significant lacrimal gland cell apoptosis;the protein expression of Caspase-3 and Fas increased,and the Bcl-2 protein expression decreased in the model group(P＜0.05).Compared with the model group,the EA group rabbits showed improvements in the SⅠT,TBUT,and CFS score(P＜0.05),with reduced pathological damage in the lacrimal gland tissues and lacrimal gland cell apoptosis;the protein expression of Caspase-3 and Fas decreased,and the Bcl-2 protein expression increased in the EA group(P＜0.05).The sham EA group showed no significant differences from the model group in the above indexes(P＞0.05).Conclusion EA can improve the ocular surface function of dry eye rabbits,inhibiting lacrimal gland cell apoptosis,down-regulating the protein expression of Caspase-3 and Fas,and up-regulating the protein expression of Bcl-2 in the lacrimal gland cells.
目的 通过分析具有代表性的三棱针典型结构图,探究三棱针外形结构的发展演变规律,以期为制订三棱针的ISO国际标准提供依据.方法 收集整理古代文献和现代标准中的三棱针典型结构图,分析三棱针典型结构的特征并梳理其演变规律.结果 共收集到16 幅三棱针典型结构图,按照其出现的时间顺序,可将历史上出现过的三棱针外形按其结构特点划分为5种.结论 虽然"三棱针标准"字样未曾出现在中医药的古代文献中,但标准化的内涵与实践早已渗透其中.从古至今三棱针的外形虽不断变化,但始终保持着针头呈三棱状、三面有刃、尖端锋锐、针身呈圆柱形的基本结构.
Objective To observe the clinical efficacy of Governor Vessel moxibustion plus oral administration of Gui Lu Jiao in treating myasthenia gravis(MG).Method Eighty-four MG patients were randomized into a control group(41 cases)and an observation group(43 cases).The control group received oral Prednisone acetate for treatment,and the observation group received Governor Vessel moxibustion and oral administration of Gui Lu Jiao.Before and after the intervention,the myasthenia gravis muscular endurance scale(MGMES)score,Medical Research Council(MRC)muscle strength scale score,limb skeletal muscle index,and myoelectrophysiological indicators of orbicularis oculi fibers were observed for both groups.The serum levels of T cell subsets(CD4+,CD8+,and CD4+/CD8+),immune indicators[immunoglobulin A(IgA),immunoglobulin M(IgM),and immunoglobulin G(IgG)],and inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and interleukin-8(IL-8)]were also detected before and after the treatment.The clinical efficacy and adverse reactions were compared between the two groups.Result The total effective rate was 95.3%,69.7%,and 51.2%in the observation group after treatment and at the 6-month and 12-month follow-ups,respectively,higher than 75.6%,46.3%,and 26.8%in the control group(P＜0.05).After the treatment,the MGMES score and myoelectrophysiological indicators of orbicularis oculi fibers were lower in the observation group than in the control group(P＜0.05);the MRC muscle force scale score and limb skeletal muscle index were higher in the observation group than in the control group(P＜0.05).After the intervention,the levels of CD4+,CD4+/CD8+,TNF-α,IL-4,and IL-10 in the observation group were lower than those in the control group(P＜0.05),and the levels of CD8+,IgA,IgM,and IgG were higher in the observation group(P＜0.05).The observation group had an adverse reaction rate of 2.3%,which was lower than 34.1%in the control group(P＜0.05).Conclusion Governor Vessel moxibustion plus oral administration of Gui Lu Jiao can produce more significant clinical efficacy than oral Prednisone acetate in treating MG.This method can enhance muscle stamina and strength and improve the levels of T cell subsets,immune indicators,and inflammatory factors in the patients.
