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Quality of life measures are important for understanding child well-being, particularly in low- and middle-income countries where linguistic and cultural differences can limit the use of standardized tools. Although the PedsQL 4.0 Generic Core Scales (GCS) for Infants is widely used, no Kiswahili translation exists for infants in Kenya. This study aimed to culturally adapt the PedsQL 4.0 GCS for use in western Kenya. Cultural adaptation followed Mapi Research Institute guidelines. Two bilingual translators independently completed forward translations, which were reconciled into a Kiswahili version. A third translator conducted backward translation, with discrepancies resolved by a multidisciplinary committee. Cognitive interviews were conducted with nine bilingual caregivers using the adapted 13–24 month scale to assess comprehension and cultural relevance. Feedback was used to revise wording and ensure conceptual equivalence. Identical changes were applied to the 1–12 month scale. Nine caregivers (89