百时美施贵宝公司是一家以科研为基础的全球性的从事医药保健及个人护理产品的多元化企业，其主要业务涵盖医药产品、日用消费品、营养品及医疗器械。 百时美施贵宝公司在美国已有100多年历史的百时美施贵宝，今天已发展成为一家年销售额为200多亿美元，遍及世界120多个国家和地区，拥有54000多名员工的全球性多元化企业，公司总部设在美国纽约。
Biologic combinations that modulate immune responses are increasingly used in oncology, enhancing anti-tumor immunity but also raising the risk of anti-drug antibody (ADA) development. Nivolumab administered in combination with ipilimumab results in significantly higher nivolumab ADA incidence (44
Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with heart failure with preserved ejection fraction (HFpEF), independent of shared risk factors. The aim of this study was to discover metabolic pathways associated with HFpEF in individuals with MASLD to explore shared mechanisms and identify biomarkers of risk. We examined HFpEF cases and non-HF controls in the Duke CATHeterization GENetics (CATHGEN) study. HFpEF was defined as left ventricular ejection fraction (LVEF) ≥ 45
Introduction:The FDA approval in 2024 of the M1/M4 muscarinic receptor agonist xanomeline and trospium chloride (formerly known as KarXT) introduces a novel alternative to dopamine-receptor antagonism or partial agonism for schizophrenia treatment. All prior approved treatments rely on direct D2-receptor antagonism or partial agonism, limiting patient experiences to this mechanism. To explore this shift, we conducted a qualitative study examining patient experiences with a muscarinic receptor agonist. A companion report addresses perceived symptom changes; this report focuses on changes in quality of life (QoL) and medication satisfaction. Study Methods:A qualitative substudy was embedded in a larger 52-week open-label trial of xanomeline/trospium monotherapy in stable schizophrenia outpatients transitioned from standard antipsychotics. It included semi-structured interviews at 6 weeks (n = 70) and 6 months (n = 47) after initiating treatment. Narratives regarding change in QoL attributed to xanomeline/trospium and medication satisfaction were coded and categorized. Study Results:Before starting xanomeline/trospium, most participants reported QoL challenges across the following domains: physical (95.7%), social (85.7%), and role (80.0%) functioning, and emotional well-being (74.3%). For the two most common issues in each domain, the percentage of participants who improved by 6 weeks ranged from 44.8% to 83.3%, increasing to 68.0% to 95.2% by 6 months after xanomeline/trospium initiation. Few participants worsened in any of these domains. Participants rated their satisfaction with xanomeline/trospium highly (mean = 8.1 out of 10 at both assessments) and 93.2% would recommend it to a friend. Discussion:Xanomeline/trospium treatment was associated with meaningful improvements across QoL domains that participants had previously identified as challenging, and most participants reported high satisfaction with the medication. These findings should be interpreted cautiously given the open-label design, absence of a comparator group, and potential selection and attrition biases. Within these constraints, the results provide exploratory, participant-centered insights into treatment experience and suggest that muscarinic agonists may influence both symptomatic and functional aspects of schizophrenia, warranting further controlled investigation.
