To quantify differences of global and segmental sagittal thoracolumbar alignment between normal individuals and adolescent idiopathic scoliosis (AIS) according to primary curve types. Radiographic parameters were compared between 11161115 normal adolescents and young adults versus 17781779 AIS. Thoracic kyphosis (T1-T12), lumbar lordosis (L1-S1), segmental alignment (T1-T5, T5-T10), thoracolumbar junction (T10-L1), segmental lordosis (L1-L4, L4-S1), lumbar and thoracic apex, thoracolumbar inflection point, global alignment parameters (SVA C7, SVA C2, OD-HA, TPA, GT, SSA) and pelvic parameters (PI, PT, SS) were measured. C2 and C7 SVA was smaller and more posteriorly located in AIS compared to normal. Primary thoracic curves (Lenke 1, 2 and 3) had the lowest TK at T5-T10 compared to normal and primary thoracolumbar curves (Lenke 5 and 6). The thoracolumbar junction T10-L1 was smallest and slightly lordotic in Lenke 1 and 2. Distal lordosis L4-S1 and PI were highest in thoracolumbar curves (Lenke 3, 5 and 6). Thoracolumbar inflexion points, thoracic and lumbar apex were located more cranial in thoracic curves (Lenke 1 and 2) compared to normal and other AIS types. Thoracic curves (Lenke 1 and 2) were hypokyphotic in the distal thoracic segment T5-T10, had a neutral thoracolumbar junction T10-L1 and their apex and thoracolumbar junction were more cranial. Lenke 3 curves had an increased lordosis in the distal lumbar segment L4-S1. Primary lumbar curves (Lenke 5 and 6) had a higher PI and distal lordosis L4-S1, and the highest C7 SVA.
Incisional hernias (IH) represent common complications following abdominal surgeries, with emergency repair associated with increased morbidity and mortality. This scoping review aimed to map the existing literature on emergency incisional hernia repair, identify research gaps, and inform future guideline development. A comprehensive literature search was conducted in PubMed MEDLINE and SCOPUS for studies published between January 2000 and August 2024. Articles addressing any aspect of emergency incisional hernia repair in adults were included. Data extraction focused on study characteristics, patient demographics, surgical approaches, and outcomes. Of 801 unique articles identified, 73 met the inclusion criteria. Most were cohort studies (73.97
Acute kidney injury (AKI) requiring renal replacement therapy (RRT) is common in intensive care units (ICUs), yet optimal amikacin dosing in this context remains poorly understood. We conducted a prospective observational study across 18 French hospitals from April 2020 to January 2022. Adult ICU patients (aged > 18 years) receiving their first amikacin dose while on RRT were included. Data on demographics, RRT modalities, amikacin dosing, and therapeutic drug monitoring were collected. Using a pharmacokinetic modeling approach, we evaluated various amikacin regimens and simulated target attainment probabilities across different minimum inhibitory concentrations (MICs). A total of 111 patients were included, with approximately two-thirds receiving continuous RRT. The median amikacin dose was 27 (25–30) mg/kg. Amikacin peak (Cmax) and trough concentrations were monitored in 53 (47.8
