Charing Cross and Westminster Medical School existed as a legal entity for 13 years, as the midpoint of a series of mergers which strategically consolidated the many small medical schools in west London into one large institution under the aegis of Imperial College London.In 1984, Charing Cross Hospital Medical School and Westminster Hospital Medical School merged to form the Charing Cross and Westminster Medical School. This move was part of a series of mergers in the London medical schools in the early 1980s, which foreshadowed the second, larger round of mergers in the late 1990s.Based at the Charing Cross Hospital site in Hammersmith and Chelsea and Westminster Hospital in Chelsea, the new medical school took the form of its larger precursor (CXHMS) in using "X" as an abbreviation for "Cross". The medical school also maintained academic units at the university hospitals of Queen Mary's Roehampton, West Middlesex, Ashford and Hillingdon.In 1997, CXWMS merged with Imperial College, London (whose medical department was at St Mary's Hospital Medical School), The National Heart and Lung Institute and the Royal Postgraduate Medical School to form Imperial College School of Medicine.
Antibody-based therapy has attracted interest because of its potential to improve selectivity. But the limitations of antibodies as delivery systems are well known and the objective of restricting action to tumor sites requires additional means. The ADEPT concept introduced two components, enzyme and prodrug, that have the advantage that they can be secondarily manipulated to augment the selectivity of the primary delivery systems.
Goya was born in Fuentetodos. Goya's early career continued with religious subjects such as the ceiling of part of the Church of El Pilar in Saragossa in 1772. Goya studied and copied the paintings of Velasquez who, like the Spanish school in general, had a tendency to portray humble models and often invalids. He had generalized cramps followed by ''total paralysis that froze him into a protracted spasm of helplessness.'' He had a high fever with hallucinations, was totally confused, and disorientated with loss of memory of his own name, place of birth, and his occupation as a celebrated painter. After several months of illness, Goya slowly recovered but not his hearing. He heard loud and constant noises, buzzing and roaring and ringing in his head. But he had more and more difficulty hearing the sounds of the real world, and could hardly make out the syllables of ordinary speech. His balance was badly affected; he could not go up and down the stairs without feeling the danger of falling over. He had fainting fits and spells of semi-blindness, He often felt nauseated and ready to throw up. He also had weakness and delirium. Further, Goya returned to the South of Spain in 1796. Even after four years of his illness he was still suffering from the after effects, walking with unsteady steps because of his imbalance and holding on to walls.
The acute abdomen is a clinical entity, defined by the sudden onset of abdominal symptoms (Figure 1). The clinical course can develop over a variable time period, and may result from a wide range of intra- and extra-abdominal pathologies. The key clinical decision is to determine whether surgical intervention is required. A thorough understanding of the pathophysiology will assist in the successful interpretation of the symptoms and signs, and thus guide diagnosis.
OBJECTIVE:Depressive symptoms in schizophrenia are associated with a substantial morbidity and mortality burden. The 'International Survey of Depression in Schizophrenia' was designed to evaluate current awareness and clinical approaches in this area.METHOD:A 48-item questionnaire was distributed to approximately 80 000 consultant psychiatrists world-wide. Responses were analysed using descriptive statistics.RESULTS:Respondents demonstrated considerable awareness of the prevalence and consequences of depression in schizophrenia. Although there was widespread adjunctive use of antidepressants, one-third of respondents indicated that they rarely or never prescribe these agents in combination with antipsychotic medication. There were considerable variations in opinions about the best approach to the treatment of depressive symptoms associated with schizophrenia.CONCLUSION:The considerable clinical burden of depressive symptomatology in schizophrenia was acknowledged by the majority of respondents to this survey. There was, however, little agreement on the best management strategy.
