This manuscript reviews the clinical spectrum and management of Fontan-associated liver disease (FALD) and protein-losing enteropathy (PLE), examining how chronic venous hypertension leads to multisystem injury. Liver fibrosis is now recognized as an early and nearly universal complication after the Fontan procedure, with cirrhosis affecting approximately 43
Introduction: Despite growing interest in the nature and impact of cognitive disengagement syndrome (CDS), few studies have examined environmental factors associated with CDS such as the possible role of trauma exposure. The current study used a community sample of young adolescents and a multi-informant, multi-method design to examine the association between type of trauma exposure and symptoms of CDS and attention-deficit/hyperactivity disorder (ADHD). Methods: Youth ages 10—12 (N = 341, 52.7
Acute kidney injury is common among critically ill children and independently associated with morbidity and mortality, particularly in those receiving kidney replacement therapy (KRT). As KRT is not innocuous, standardizing its delivery is critical for accurate outcome tracking. Establishing key performance indicators (KPIs) is essential to guide quality improvement and support decision-making through ongoing monitoring of KRT processes. This systematic review evaluated existing evidence on KPIs related to KRT delivery in critically ill pediatric populations. A comprehensive search of Ovid MEDLINE, Ovid Embase, CINAHL, and the Cochrane Library was conducted for studies published from inception to February 2025. Eligible studies reported KPIs related to dialysis processes in critically ill children receiving KRT. Critically ill children receiving all KRT modalities were assessed for KPIs according to the Donabedian framework, with each KPI stratified based on whether it measured a process related to KRT care. Six reviewers independently screened, selected, and appraised studies using the risk-of-bias tool appropriate for each study design. Data were summarized narratively. Of 7,111 citations screened, 107 studies met inclusion criteria, comprising 57 retrospective cohorts, 27 case series, 16 prospective cohorts, 4 case reports, 2 randomized controlled trials, and 1 audit. Most studies (66.7
Pulmonary MRI in neonates can be performed with quality comparable to radial 3D ultrashort echo time (UTE) MRI in significantly less time using a FLORET trajectory. Eighteen NICU patients with severe bronchopulmonary dysplasia (BPD), age 40.9 ± 3.0 weeks at time of imaging, underwent MRI using Radial and FLORET UTE at 1.5 T. Pulmonary signal-to-noise ratio (SNR), lung density, and radiologist scoring of motion artifacts and image quality were compared across sequence types. FLORET UTE reduced scan time by 75
The prospective pediatric Continuous Renal Replacement Therapy (ppCRRT) registry identified the degree of fluid accumulation (FA) at continuous kidney replacement therapy (CKRT) initiation as a predictor of adverse outcomes in children. These predate major advancements in CKRT technology and fluid stewardship. We aimed to describe the epidemiology of FA at CKRT initiation and associated outcomes in a contemporary paediatric cohort. Secondary analysis of Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK), a retrospective, multicenter study (35 centers, 9 countries) of patients ≤ 25 years treated with CKRT from 2015 to 2021. Primary Outcome: survival to ICU discharge. Secondary outcomes: ventilator-free and ICU-free days. A total of 1027 patients were included in this analysis. Survival to ICU discharge was 64.5
