CURE International (also known as CURE, formerly Crippled Children's United Rehabilitation Effort or CCURE or C²URE) is a Christian nonprofit organization based in Grand Rapids, Michigan. CURE's efforts are focused on providing medical care to children suffering primarily from orthopedic and neurological conditions. The organization's stated mission is "healing the sick and proclaiming the kingdom of God." The organization operates hospitals in Ethiopia, Kenya, Malawi, Niger, the Philippines, Uganda and Zambia. CURE also operates a pediatric specialty training program called CURE Neuro helping children with hydrocephalus and spina bifida survive and thrive through global partnerships. Since its inception, CURE Neuro has trained 41 surgeons from 23 low- and middle-income countries..
Aims:The aim of this study was to achieve consensus on important topics related to tenosynovial giant cell tumour (TGCT) and giant cell tumour of bone (GCTB), and to identify areas for future research. Methods:In January 2026, a consensus meeting, The Birmingham Orthopaedic Oncology Meeting (BOOM), held in Cape Town, South Africa, gathered 314 delegates from 59 countries to debate 21 consensus statements on tenosynovial giant cell tumour (TGCT) and giant cell tumour of bone (GCTB) through a modified Delphi process. Results:Of the 21 statements, two achieved unanimous consensus, 18 strong consensus, and one moderate consensus. Unanimous consensus was reached for prioritizing joint-preserving intralesional curettage in GCTB when feasible, and for supporting non-surgical approaches in anatomically challenging cases, particularly sacral lesions. The statement addressing the role of denosumab in GCTB achieved only moderate consensus. The use of adjuvants in GCTB, as well as the management of recurrent and systemic GCTB, including long-term use of denosumab, reached strong consensus. Strong consensus was achieved in the surgical and non-surgical management for both primary and recurrent TGCT. Surveillance strategies for both TGCT and GCTB generated substantial discussion despite strong consensus, reflecting ongoing uncertainty and lack in evidence. Conclusion:This international consensus provides practical guidance for the management of TGCT and GCTB while identifying important gaps in evidence. Joint-preserving surgery remains central to the treatment of GCTB, with selective integration of systemic therapies and individualized surveillance. The consensus framework highlights priorities for future collaborative research in orthopaedic oncology.
According to GLOBOCAN 2020 Breast cancer is the most common cancer among women and the prevalence is increasing worldwide and in Ethiopia. This review assessed studies conducted in Ethiopia on the clinical features and epidemiology of breast cancer. Data base search conducted PubMed, Google Scholar African Journals Online (AJOL), Cumulative Index of Nursing and Allied Health Literature (CINAHL) and Hinari without time restrictions. The search keywords included; prevalence and pattern, clinical presentation, histological and molecular subtypes, and management. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline to identify, search, extract articles, and report this systematic review. The protocol was registered in PROSPERO, ID: CRD42023403320. Twenty studies were included in the review with 33,369 participants and 3 were community-based and 17 were hospital-based. In all except two reviewed studies, breast cancer is the most common cancer among women of Ethiopia. The most frequent presenting symptom was a breast lump/mass and commonly affected side was right breast. Most patients presented at a late stage and they were premenopausal age group. The commonest histology type is ductal carcinoma, that the most prevalent receptor was estrogen receptor positive, and the most common molecular subtype was Luminal A in pathology samples. Surgery is main stay of treatment and the most common surgical technique practiced in Ethiopia is modified radical mastectomy. Breast cancer incidence is rising, and it accounts for the major cancer burden in the country. There is a need for additional awareness-raising and health education because delayed presentation are critical problems throughout Ethiopia. For planning and monitoring cancer patterns, comprehensive demographic and clinical data from a population or facility-based registry are needed in the regions. The available treatment options are still limited in Ethiopia it needs infrastructural development.
Abstract Background Breast cancer is the most common cancer among women worldwide and in Ethiopia. Even though there are scattered studies in Ethiopia, no study has attempted to establish systematic knowledge in the area. Hence, we reviewed studies that examined the epidemiology, clinical and histological characteristics, and management of breast cancer in Ethiopia. Methods We searched PubMed, Google Scholar, and Science Direct without other restrictions from November 1, 2021, until June 20, 2022. The search keywords included various aspects of breast cancer, including epidemiology, clinical presentation, histological and molecular subtypes, and management. We followed the Preferred Reporting Items for Systematic Reviews and MetaAnalyses (PRISMA) guideline to identify, search, extract articles, and report this systematic review. The protocol was registered in PROSPERO, ID: CRD42023403320. Results of the initial 883 studies identified, 20 studies included with 31,831 participants. from 20 included articles, 3 were community-based and 17 were hospital-based. In most reviewed studies, breast cancer is the most common cancer among women of Ethiopia. The most typical presenting symptom was a breast lump affecting the right breast. Most patients presented at a late stage and they are premenopausal age group. The commonest histology type is ductal carcinoma, that the most prevalent receptor was estrogen receptor positive, and the most common molecular subtype was Luminal A in pathology samples. Conclusion Breast cancer incidence is rising, and it accounts for the major cancer burden in the country. There is a need for additional awareness-raising and health education because delayed presentation are critical problems throughout Ethiopia. For planning and monitoring cancer patterns, comprehensive demographic and clinical data from a population or facility-based registry are needed in the regions.
— We investigate the effect of lighting conditions and camera shutter time on heart rate measurement using remote photoplethysmography (remote-PPG) on healthy volunteers in a simulated ICU setting. In the used range of lighting conditions (132-548 lux), there exists a range of shutter times (5-32 ms), in which a mean 3 beats-per-minute (BPM) agreement of 90-100% with the contact PPG sensor is achieved. This range is limited by the saturation of the skin pixels. These results indicate that shutter time control is unnecessary beyond avoiding saturation. Clinical Relevance — Replacing spot checks by continuous monitoring in a hospital will lead to timely detection of adverse events. Technologies for remote-PPG will allow continuous monitoring in a clinical setting.
