Ann & Robert H. Lurie Children's Hospital of Chicago, formerly Children's Memorial Hospital and commonly known as Lurie Children's, is a nationally ranked pediatric acute care children's hospital located in Chicago, Illinois. The hospital has 360 beds and is affiliated with the Northwestern University Feinberg School of Medicine. The hospital provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21 throughout Illinois and surrounding regions. Lurie Children's also sometimes treats adults that require pediatric care. Ann & Robert H. Lurie Children's Hospital of Chicago also features a state designated Level 1 Pediatric Trauma Center, one of four in the state. The hospital has affiliations with the nearby Northwestern Memorial Hospital and the attached Prentice Women's Hospital. Lurie is located on the university's Streeterville campus with more than 1,665 physicians on its medical staff and 4,000 employees. Additionally, Lurie Children's has a rooftop helipad to transport critically-ill pediatric patients to the hospital.Lurie Children's hosts 70 pediatric subspecialties and has locations across the Chicago area. Physicians and staff provided care for more than 212,000 children in 2018, from 48 states and 49 countries.On the 2019–2020 U.S. News & World Report rankings of the Best Children's Hospitals, Lurie Children's is the top children's hospital in Illinois, ranking in all 10 specialties.S.S.S.S.S.S.S.
A comprehensive understanding of the complex three-dimensional anatomy of the temporal bone and inner ear is critical for accurate diagnosis, assessment, and surgical planning in patients being evaluated for cochlear implantation. A systematic imaging approach enables radiologists to identify anatomic variants, predict surgical challenges, and contribute to safer, more effective cochlear implantation in children. Anatomical variations and congenital malformations may affect implant eligibility, alter surgical approach, and influence clinical outcome. This review provides an overview of the normal anatomy and imaging appearance of the mastoid, middle ear, and inner ear, with great emphasis on key anatomic variants and malformations relevant to preoperative evaluation. Characteristic imaging findings and clinical implications of common malformations are illustrated using examples from our institutional experience. Vascular and facial nerve variants with surgical relevance are also reviewed. Finally, postoperative imaging assessment of implant positioning, electrode integrity, and potential complications is discussed.
Vagus nerve stimulation (VNS) is an established adjunctive therapy for pediatric drug-resistant epilepsy (DRE). While 50
There are few prospective studies of mycophenolate mofetil (MMF) versus cyclophosphamide (CYC) for pediatric lupus nephritis (pLN) and none evaluating rituximab (RTX). The Prospective Pediatric Lupus Nephritis Registry (ProPeL-R) enrolled patients < 21 years within 4 weeks of an initial kidney biopsy diagnostic of pLN. Demographic, clinical, and laboratory data were collected prospectively at enrollment, 3 months, 6 months, and then every 6 months thereafter for up to 5 years of follow-up. For this study, we compared patients receiving initial therapy with corticosteroids (CS) and either MMF (n = 33) vs. CYC (n = 18), and those treated with CS, either MMF or CYC, with RTX (n = 20) vs. without RTX (n = 51). Histology consisted of 18
Adolescents and young adults account for a large proportion of new HIV cases, and this age subgroup has worse outcomes across the HIV care continuum than adults. The lack of harmonization of data elements from implementation science trials is an important barrier that limits the learning across settings and the ability to accelerate adoption of effective implementation strategies. We aim to close this gap by assessing the ability to harmonize data elements across seven studies in the Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings (PATC3H) consortium. The PATC3H team initiated a collaborative process to prospectively develop harmonized measures and then retrospectively implement additional harmonization based on data collected. We harmonized items on socio-demographic characteristics (12 items), economic stress (8 items), social support (12 items), sexual behaviors (20 items), mental health (24 items), substance use (33 items), HIV care continuum (11 items), and implementation science (126 items) for two or more of the studies. We present analysis of selected harmonized measures that revealed similarities and differences across studies which will be important to consider in future comparative assessments. Key lessons learned are that flexibility is required to collect measures across multiple settings, specifying minimum sample sizes will support meaningful analysis and identifying core measures can help prioritize data elements that can be consistently collected. The PATC3H consortium collaboration has shown that it is feasible to collect harmonized data across implementation science trials and future studies can build on these harmonization efforts.
Prospective, multi-institutional surgical data collection in pediatric neuro-oncology remains limited despite substantial variation in operative and perioperative management across institutions. To address this, we are developing the NeuroPoint Alliance (NPA) Quality Outcomes Database (QOD) Pediatric Tumor Surgery Registry. Here, we used a modified Delphi process to define a core outcome set for the registry. A modified Delphi study was conducted among pediatric neurosurgeons serving as site principal investigators for the proposed registry. Candidate data elements were rated on a 9-point Likert scale. Consensus for inclusion was predefined as ≥70
