Game engines provide real-time simulation, rendering, physics, interaction, networking, and asset pipelines, making them valuable not only for games but also for 3D applications in healthcare, robotics, architecture, manufacturing, and related domains. Because game development is where these systems are most mature and publicly available, it offers a practical testbed for evaluating coding agents that must modify C++ code within stateful, interactive, real-time systems. We present GameEngineBench, a benchmark for evaluating coding agents on scoped C++ implementation tasks inside Unreal Engine 5 projects, built from nine real-world game repositories. The evaluation set consists of 110 tasks spanning gameplay mechanics, multiplayer behavior, AI and world orchestration, animation and movement, UI and session code, loading behavior, online-service integration, persistence, data serialization, XR behavior, and rendering-oriented plugins. These tasks require models to make native C++ changes that compile and satisfy behavioral tests within executable Unreal Engine projects. Across twelve evaluated configurations, the strongest model reaches 55.5% pass@1, while 31 tasks remain unsolved by every configuration. Our results demonstrate that frontier coding agents continue to struggle with deeply integrated C++ development for real-time interactive software, highlighting game-engine benchmarks as a valuable complement to existing software engineering evaluations.
Importance:Increasing numbers of children are conceived using infertility treatment; concerns remain about potential effects on child neurodevelopment. Objective:To evaluate whether infertility treatment is associated with child neurodevelopment and whether such an association may be attributable to underlying subfecundity. Design, Setting, and Participants:This cohort study was conducted among mother-child dyads in the National Institutes of Health Environmental Influences on Child Health Outcomes Cohort, with infants conceived between 1998 and 2022. Associations of subfecundity and infertility treatment with neurodevelopmental outcomes were assessed among children ages 2 to 10 years. Data were analyzed from May 14, 2025, to March 31, 2026. Exposure:Subfecundity was defined as prior consultation for, treatment of, or diagnosis of infertility for either partner; at least 2 prior miscarriages; or ever having had unprotected heterosexual intercourse for 12 months without conceiving. Infertility treatment was categorized as in vitro fertilization (IVF) or non-IVF treatment. Main Outcomes and Measures:Harmonized caregiver responses to the Strengths and Difficulties Questionnaire and the Child Behavior Checklist yielded continuous raw scores for externalizing and internalizing problems. The total raw Social Responsiveness Scale (SRS) score quantified autism-like symptoms. Caregivers reported physician diagnosis of autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). Results:Among 15 382 mother-infant dyads, there were 14 191 unique maternal participants (mean [SD] age at delivery, 30.9 [5.33] years; 8780 parous participants [57.1%]). ASD and ADHD were diagnosed in 876 offspring (7.6%) and 819 offspring (7.1%), respectively. In generalized linear models, subfecundity was associated with higher externalizing problem and SRS scores among all pregnancies (externalizing problems: b = 0.47 [95% CI, 0.14-0.81]; SRS score: b = 1.08 [95% CI, 0.01-2.14]) and when restricted to natural conceptions (externalizing problems: b = 0.45 [95% CI, 0.07-0.83]; SRS score: b = 1.12 [95% CI, -0.09 to 2.34]). Offspring of parents with subfecundity had higher odds of ASD (overall: odds ratio [OR], 1.27 [95% CI, 1.03-1.57]; natural conceptions: OR, 1.31 [95% CI, 1.04-1.64]). Children conceived via non-IVF treatment had higher odds of ADHD compared with those conceived via natural conception with subfecundity (OR, 1.77 [95% CI, 1.16-2.68]) or without subfecundity (OR, 1.54 [95% CI, 1.05-2.25]). There were no significant associations for IVF treatment. Conclusions and Relevance:In this large US cohort study, subfecundity was associated with elevated scores for caregiver-reported symptoms of behavioral problems and higher odds of ASD diagnosis, independent of infertility treatment. Non-IVF treatment was associated with ADHD, warranting further research into specific indications for treatment that may increase risk of offspring neurodevelopmental problems.
Abstract We announce updates to the aims and scope of Earth's Future that introduce three Thematic Areas: Climate Impacts, Communities and Resilience, and Sustainable Resource Systems. These additions provide focal points for community building and editorial leadership within the journal's broad, transdisciplinary mission. We describe the motivation for these changes, outline each thematic area, and reaffirm that Earth's Future remains open to submissions across the full scope of Anthropocene science.
