The hospital serves more than 130,000 residents in the Lower Naugatuck Valley. Griffin Hospital is Derby's top employer and one of New Haven County's largest employers. Griffin Hospital serves as a flagship hospital for Planetree, an international healthcare organization that centers on patient care. It is a clinical campus of the New York Institute of Technology College of Osteopathic Medicine and provides clinical clerkship education for the medical school's osteopathic medical students.
BACKGROUND:Cardiovascular disease (CVD) is a leading cause of death worldwide. Weekend sleep recovery (WSR), the practice of extending sleep on weekends to compensate for weekday sleep loss, may influence cardiovascular health. This study examines its association with coronary artery disease (CAD) and myocardial infarction (MI) using data from the National Health and Nutrition Examination Survey (NHANES). METHODS:A cross-sectional study of 14,335 NHANES participants analysed self-reported weekday and weekend sleep durations. The weekend-to-weekday sleep duration ratio (SDR) was calculated, classifying participants as WSR (SDR > 1) or non-WSR (SDR ≤ 1). Multivariate logistic regression models, adjusted for demographics and comorbidities, assessed the association between WSR and CAD/MI risk. RESULTS:Participants had a mean age of 43.9 ± 23.4 years, 52.5% were female, 4.83% had CAD, and 4.46% had MI. The mean weekday and weekend sleep durations were 7.7 ± 1.7 and 8.3 ± 1.8 h, respectively, with 64.8% having WSR. WSR was associated with a reduced risk of CAD and MI (OR = 0.79, 95% CI: 0.67-0.93, p = 0.005), particularly among those with 5-6 h of weekday sleep, older adults, White individuals, and those with diabetes or hypertension. The protective effect was also observed in smokers and individuals with class I and III obesity, but was not significant in Black individuals, non-smokers, or those without obesity. CONCLUSIONS:WSR is associated with lower CAD and MI risks, particularly in those with intermediate weekday sleep and specific subgroups. However, its impact varies across populations, warranting further research.
Background Heart failure with preserved ejection fraction (HFpEF) accounts for a substantial and growing proportion of heart failure hospitalizations, yet diagnosis remains challenging due to the need for integrated clinical and echocardiographic assessment rather than a single definitive parameter. Project Rationale Variability in interpreting echocardiographic findings leads to diagnostic uncertainty and delays in treatment. Embedding the H2FPEF score into echocardiogram reports may standardize assessment and improve recognition of HFpEF. Project Summary A quality improvement initiative at Griffin Hospital integrated H2FPEF scoring into echocardiogram reports for patients with suspected new acute heart failure and preserved left ventricular ejection fraction. Among 44 eligible patients, 29 had complete data for score calculation. The score supported HFpEF diagnosis in 17 patients and ruled it out in 5, improving diagnostic clarity. Guideline-directed medical therapy was initiated in most confirmed cases, demonstrating impact on management. Take-Home Message Embedding H2FPEF scoring into routine echocardiography reporting is feasible and improves diagnostic consistency and treatment initiation in suspected HFpEF.
e19094 Background: WM/LPL is an indolent B-cell Non-Hodgkin Lymphoma with prolonged survival and predisposition to secondary malignancies (SM) influencing clinical outcomes and survivorship care. We evaluated the incidence, demography, treatment utilization, and outcomes of SM in patients with WM/LPL using population-based data. Methods: SEER-22 database was used to identify patients with LPL/WM diagnosed between 2000–2022 and stratified by SM. Overall survival (OS) was analyzed using Kaplan–Meier survival analysis and propensity score matched Cox regression was used to assess mortality risk. Hazard ratios were reported, with p<0.05 deemed significant. Results: 22,170 patients with WM/LPL were identified, with a median age of 71 years (IQR 16); the cohort was predominantly male (59.0%), White (84.0%), had a median household income of $50,000–$75,000 (48.9%), and resided primarily in urban areas (89.5%). Among all WM/LPL patients, 20.8% (n=4,615) developed a SM. Patients who developed SM were older than those without (median age 75 vs 70 years, p<0.0001) with 45.2% alive at predefined follow-up. The most common solid organ SM were gastrointestinal adenocarcinoma (16%), prostate cancer (14%), and lung adenocarcinoma (9%), while the leading hematologic SM were plasma cell myeloma (6%), diffuse large B-cell lymphoma (5%), and myelodysplastic syndrome (2%). 35.3% of the cohort received chemotherapy, while 0.1% received cancer-related surgery or radiation. On multivariable analysis, older age (OR 0.82, 95% CI 0.81–0.83), male sex (OR 0.59, 95% CI 0.44–0.80), urban residence (OR 1.99, 95% CI 1.24–3.18), and higher income (OR 2.16, 95% CI 1.13–4.15) were significantly associated with SM diagnosis. Kaplan–Meier analysis demonstrated inferior survival among patients with SM (54.8% vs 45.2%, p<0.0001), with shorter median OS (9 vs 14 years, log-rank p<0.001). Similarly, Propensity-matched analysis revealed worse OS in patients with SM (HR 1.15, 95% CI 1.09–1.22, p<0.001). Median OS varied substantially by SM site (see Table). Conclusions: Our study demonstrates a substantial burden of SMs among patients with WM/LPL and are associated with substantially inferior survival despite the indolent nature of the disease. The marked heterogeneity in SM types and outcomes highlights the need for risk-adapted surveillance, survivorship-focused care, and equitable strategies to address disparities and improve long-term outcomes in this population. SM Site Median OS (years) IQR p-value Hepatopancreatobiliary 1 0 <0.05 CNS 3.5 9 <0.05 Breast 3 6 <0.05 Colorectal 4 3.5 <0.05 Lymph Node 5 8 <0.05 Blood 6 7 <0.05 Lung 7 9 <0.05 Head & Neck 6.5 8.5 <0.05 Melanoma 9 10 <0.05 Urogenital 10.5 7 <0.05
