Gurucharan College, popularly known as GC College, is a college imparting 10+2, undergraduate, certifications (self-financing) and postgraduate (self-financing) education under the aegis of Assam Higher Secondary Education Council, Guwahati and Assam University, Silchar.Gurucharan College, Silchar is affiliated under Assam University (Central University).
Cancer remains a major global health challenge. Natural compounds, such as curcumin, resveratrol, genistein, thymoquinone, and paclitaxel, show chemopreventive activity by modulating signaling pathways, including PI3K/Akt, NF-κB, and p53. These agents also promote apoptosis, autophagy, and DNA repair. However, their clinical use is restricted by poor solubility, instability, and low bioavailability. Nanotechnology offers solutions by improving stability, enhancing pharmacokinetics, and enabling targeted delivery. Liposomes, polymeric nanoparticles, dendrimers, and albumin-bound systems amplify the anticancer effects of natural compounds. Preclinical studies confirm improved efficacy, while early clinical trials reveal both promise and barriers. The key translational challenges include immune clearance, large-scale reproducibility, and regulatory approval. This review highlights the synergy between nanotechnology and natural compounds in cancer chemoprevention and outlines opportunities for future research.
INTRODUCTION:Diabetic nephropathy (DN) is a progressive renal complication that significantly contributes to end-stage renal disease. Hyperglycaemia contributes to the formation of advanced glycation end-products (AGEs). The interaction between AGEs and their receptor (RAGE) plays a key role in the progression of DN. RAGE activation increases oxidative stress and promotes inflammation, thereby evoking cellular and molecular damage. Together, these events result in kidney injury and varying degrees of proteinuria. This study aims to evaluate the drug-like properties of potential natural compounds derived from Curcuma caesia and their potential effectiveness against DN. METHODS:This study investigates the antioxidant properties of Curcuma caesia (CC) rhizome extracts, alongside in silico methodologies including molecular docking, QSAR, and ADMET analysis to identify potential metabolites. RESULTS:In this study, we examined the potential of phytochemicals identified from the rhizome extracts of Curcuma caesia (CC) that may mimic AGEs and inhibit RAGE activation. We assessed whether these phytochemicals could prevent ROS accumulation and inflammation, thereby providing renoprotection in a diabetic milieu. Using molecular docking and ADMET analysis, we identified two compounds, Lappaol A and Piperaduncin B, in the methanolic extract of CC, which demonstrated a stronger affinity for interacting with RAGE than the AGE compound MODIC and the RAGE inhibitor Azeliragon. DISCUSSION:Since the interaction between AGEs and RAGE contributes to major pathological events in the development of DN, inhibiting this interaction could be a valuable therapeutic strategy against DN and other AGE-mediated pathologies such as retinopathy and neuropathy. Virtual screening of the identified compounds revealed that Lappaol A and Piperaduncin B effectively bind to RAGE and may interrupt RAGE activation, thereby potentially slowing the progression of DN. CONCLUSION:These natural compounds exhibited promising drug-like characteristics against the target protein RAGE and may serve as lead compounds for the development of RAGE inhibitors. The study recommends further in vitro and in vivo investigations to assess the therapeutic potential of these identified compounds in the treatment of diabetic nephropathy.
IntroductionIndigenous ethnic fermented products have gained recognition as valuable sources of probiotic bacteria, which play a crucial role in maintaining the natural balance of the gut microbiota.MethodsTwenty-five samples of rice-based fermented products were analyzed, recovering 16 LAB isolates, preliminarily identified by morphological and biochemical tests, and further confirmed using 16S rRNA gene sequencing. Subsequent in vitro assessments, safety evaluations and technological properties were performed on all isolated strains.ResultsThe potential probiotic strains were able to tolerate low pH, gastric juice, bile salts, and pancreatin enzymes; however notable variations in resistance were also observed and several strains demonstrated a significant ability of the strains to adhere to intestinal epithelial cells. All the isolates lacked DNase and hemolytic activity, confirming the safety of the isolates. Antibiotic susceptibility profiles indicated no harmful resistance patterns and displayed significant antagonistic activity against test pathogens. Furthermore, the study reported the absence of technological properties, specifically in terms of proteolytic, lipolytic, and amylolytic activity.DiscussionMost of the isolated strains showed significantly significant results with p <0.05 and <0.01, reinforcing the probiotic potential and safety of the isolates. These promising isolated strains hold potential as safe probiotics, offering significant health benefits.
Carbon dioxide (CO2) is one of the major greenhouse gases released in the atmosphere. This study aims to reduce the CO2 gas emission from the construction of flexible pavement with crumb rubber modified bitumen (CRMB) in ‘traditional hot mix asphalt’ (HMA). The aim was successfully achieved by the use of as-synthesized HAP/MgFe2O4 nanocomposite in the CRMB. The formation and characterization of the nanocomposite were performed by Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), X-Ray Diffraction (XRD), and Fourier Transform Infrared Spectroscopy (FTIR) studies. The nanocomposite was found to be very effective in the reduction of CO2 gas emission from CRMB. The reduction of CO2 gas emission was due to the inherent ion-dipole attraction of the nanocomposite for the CO2 gas. It was observed that the addition of only 2 mg of the nanocomposite to 4 g of CRMB reduces 80.56
This study investigates the green synthesis of a silver-manganese oxide (Ag-MnO) nanocomposite using Hibiscus rosa-sinensis leaf extract, focusing on its photocatalytic and antifungal properties. The synthesis employed a co-precipitation method, and the resulting composite was characterized through X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), transmission electron microscopy (TEM), and Fourier-transform infrared spectroscopy (FT-IR). The photocatalytic efficiency was evaluated against three organic dyes: eosin yellow, brilliant green, and malachite green, resulting in degradation rates of 95.65
