Assam University is a collegiate central public university located at Silchar, Assam, India. It was founded in the year 1994 by the provisions of an act enacted by the Parliament of India. The Governor of Assam is the Chief Rector and the President of India is acting as the Visitor of the university. The Chancellor is the ceremonial head of the university while the executive powers rest with the Vice-chancellor. The university has sixteen schools which offer Humanities, Languages, Environmental Sciences, Information Sciences, Life Sciences, Physical Sciences, Social Sciences, Law, Technology and Management Studies. There are 42 departments under these sixteen schools. The five districts under the jurisdiction of Assam University have 73 undergraduate colleges as on 31 March 2020. Assam University is an institutional signatory to the Global Universities Network for Innovation (GUNI), Barcelona and United Nations Global Compact (UNGC) for its commitment to educational social responsibilities.Assam University is the second Central University of Assam after Tezpur University. Both were established in 1994.The main campus, in an area of 600 acres (2.4 km2), is located at Dorgakuna, near Irongmara about 20 km from Silchar, while a second campus, Diphu Campus, has an area of 90 acres, in Diphu, Karbi Anglong district of Assam.
Cancer remains a major global health challenge. Natural compounds, such as curcumin, resveratrol, genistein, thymoquinone, and paclitaxel, show chemopreventive activity by modulating signaling pathways, including PI3K/Akt, NF-κB, and p53. These agents also promote apoptosis, autophagy, and DNA repair. However, their clinical use is restricted by poor solubility, instability, and low bioavailability. Nanotechnology offers solutions by improving stability, enhancing pharmacokinetics, and enabling targeted delivery. Liposomes, polymeric nanoparticles, dendrimers, and albumin-bound systems amplify the anticancer effects of natural compounds. Preclinical studies confirm improved efficacy, while early clinical trials reveal both promise and barriers. The key translational challenges include immune clearance, large-scale reproducibility, and regulatory approval. This review highlights the synergy between nanotechnology and natural compounds in cancer chemoprevention and outlines opportunities for future research.
Medicinal plants from the Eastern Himalayas of Northeast India are integral to traditional therapies for inflammation. This study evaluated the anti-inflammatory potential of 23 reported phytochemicals isolated from this region by targeting TNF-α, a critical mediator of autoimmune disorders. TNF-α production was induced in human peripheral blood mononuclear cells using 100 ng/mL lipopolysaccharide for 24 h and quantified using ELISA. The IC50 was calculated by probit regression, with methotrexate as the reference standard (IC50 = 1.96 µM; 94
In this research work, we have successfully designed and developed a Schiff base fluorescent chemosensor for detecting Zn2+ and Cu2+ ions using absorption and fluorescence spectroscopy. A stable complex formation of L with Zn2+ was observed with a noticeable isosbestic point in the absorption spectra. Moreover, fluorescence “on-off” response with Zn2+ and Cu2+ was observed which indicates selectively senses of Zn2+ and Cu2+. This sensor displays 1:1 stoichiometric ratio with metal ions by 1H NMR titration, mass spectra, BH-plot and Job’s plot. Moreover, the recyclability of L was assessed through EDTA showing an efficient fluorescence “off-on-off” signal response. Furthermore, the (L+Zn2+) ensemble formed was used for selective recognize F− ion. L achieved an INHIBIT logic function using different chemical inputs and corresponding emission as output. The optimized structures of L and complexes (L+Zn2+ and L+Cu2+) were used to understand spectral properties using DFT which further calculated different reactivity descriptors. This selective sensitivity of L towards Zn2+ were successfully studied and used for detection of Zn2+ intracellularly in mouse breast adenocarcinoma cell.
Tin selenide has gained significant interest due to its remarkable performance in converting energy and its highly tunable electronic and optical characteristics. The purpose of this study is to provide a theoretical investigation of the structural, electronic, elastic, optical and transport properties of SnSe in its orthorhombic and rocksalt phases employing density functional theory (DFT) within WIEN2k. Calculations are performed within the Perdew–Burke–Ernzerhof (PBE) scheme of generalized gradient approximation (GGA) and the Tran–Blaha modified Becke–Johnson (TB-mBJ) potentials excluding and including spin-orbit (SO) coupling. The measured lattice parameters are in close agreement with previously reported experimental and theoretical values. Electronic structure analysis indicates an indirect gap in its orthorhombic phase which decreases under SO coupling and a direct gap in its rocksalt phase which increases under SO coupling revealing phase-dependent band gap nature. Elastic constants calculated with IRelast confirm mechanical stability and enable derivation of additional elastic properties. SnSe in both phases exhibits strong IR–visible polarizability. In both the SO-excluded and SO-included calculations, the orthorhombic form of SnSe shows its highest absorption predominantly in the UV range whereas the rocksalt structure achieves its peak absorption from the visible into the UV region underscoring its potential for optoelectronic and solar-energy applications. The power factor per relaxation time increases with temperature for both SnSe phases, shows almost no SO effect in the rocksalt phase, displays a small SO-related enhancement in the orthorhombic phase-strongest for TB-mBJ with SO and remains higher in the orthorhombic structure highlighting its better thermoelectric efficiency.
In the present work, we have carried out (OH)-O-center dot radical-initiated oxidation of CF3OCHFCF3 by considering a H-abstraction reaction and (OH)-O-center dot-addition reaction to the C-atom of CF3OCHFCF3 with simultaneous C-C and C-O bond breaking. The energies of all the species involved in the title reaction are calculated using the M06-2X functional with the 6-311+G(d,p) basis set, and these energies are further refined using the coupled-cluster CCSD(T) method with the same basis set. The energy profile diagram and thermochemistry results indicate that the H-atom abstraction reaction pathway is energetically more favourable and thermodynamically more dominant than the OH-addition reactions with simultaneous C-C and C-O bond breaking. The rate constant analysis also indicates that the H-abstraction reaction is more favourable than (OH)-O-center dot-addition reactions. At 298.15 K and 1 atm, the estimated overall rate constant for this reaction is found to be 1.16 & times; 10-15 cm3 molecules-1 s-1, which is in good agreement with previously reported results. Furthermore, the atmospheric lifetime, radiative efficiency, global warming potentials, and photochemical ozone creation potential of the title molecule are also reported herein. Moreover, the degradation of the (center dot)OCHFCF3, CF3OC(center dot)FCF3, and CF3O(C-center dot)FH product radicals is also explored, and it is found that HFCO, (center dot)CF3, CF3O(center dot), COFCF3, and COFCF3 are formed as end products. Finally, photolytic characterisations of the reactant, intermediates, and products are analysed, and their ecotoxicities are reported.
