Hamad Medical Corporation (HMC), established by Emiri decree in 1979, is Qatar’s premier not-for-profit health care provider. Located in the State of Qatar, HMC manages nine hospitals and operates both the national ambulance service and a home healthcare service.HMC is the only healthcare organization outside the United States to receive simultaneous Joint Commission International (JCI) re-accreditation for all its hospitals and in 2011 the ambulance service and home healthcare service also received JCI accreditation..
Abstract Peripartum mental health disorders (PMHDs) constitute a substantial enormous population health problem, affecting an estimated 10% of pregnant women worldwide and 13% of women in the postpartum period. Their diagnosis and treatment at this crucial time are often hampered by a lack of precision. This review describes a framework for precision perinatal psychiatry that integrates pharmacogenomics (PGx), multi-omics, and artificial intelligence/machine learning (AI/ML). This review highlights the essential role of therapeutic drug monitoring (TDM) with PGx to manage control the expected oscillations in drug clearance during the perinatal period. AI/ML approaches may enable integration of multi-omics datasets to improve drug safety prediction and facilitate early PMHD risk identification, culminating in a proposed Precision Dosing Framework that utilizes AI/ML-informed PBPK modeling for dynamic, individualized dose adjustments across gestation and lactation. This review identifies critical translational-level challenges, including the need for very large longitudinal cohorts, solid methodological approaches, explainable AI (xAI), and ethical considerations, and outlines directions for addressing these issues to facilitate clinical implementation. This roadmap has the potential to pave the way for highly personalized, efficacious, and safe interventions, all of which may ultimately improve perinatal outcomes for mothers and infants.
Streptococcus agalactiae, or Group B Streptococcus (GBS), is a historical cause of perinatal infections and neonatal sepsis. While routine screening programs in high-income countries have led to a steady decline in neonatal complications, GBS remains a frequent colonizer of the adult gastrointestinal and urogenital tracts. Over recent decades, the incidence of invasive GBS infections in nonpregnant adults has increased substantially, leading to significant morbidity and mortality. This shifting epidemiological landscape is further complicated by the troubling emergence of multidrug-resistant lineages and hypervirulent genomic clones, such as ST283, which demonstrate severe invasive potential and unique zoonotic transmission capabilities. Because collective data on this growing threat remains fragmented, this review synthesizes global literature on invasive adult GBS, encompassing its changing epidemiology, patient risk factors, and its expanding clinical spectrum. The primary objective is to collate updated evidence to raise clinical awareness, support antimicrobial stewardship, and direct future research toward effective preventive measures and strategies.
The purpose of this study is to systematically review human evidence linking placental hormones and IGF-1 with fetal growth, birth size, and early-life metabolic programming, and to identify disease-specific translational signals relevant to fetal growth restriction, metabolically complicated pregnancy, and extreme prematurity. A systematic review of PubMed and Scopus was performed for human studies published from January 2000 to March 2025. Eligible studies examined placental growth hormone, human placental lactogen, placental IGF-axis markers, or related stress-hormone pathways in relation to birth size, fetal or infant growth, or early metabolic outcomes. Reporting was aligned with PRISMA 2020. Risk of bias was assessed using RoB 2 for randomized trials and ROBINS-I principles for observational studies. Because of substantial clinical and methodological heterogeneity, findings were synthesized narratively. Thirty-seven included studies showed that mid-gestation placental growth hormone had the most consistent positive associations with fetal growth and birth size, whereas early placental growth hormone was less informative. Cord blood IGF-1 was the most reproducible endocrine correlate of birth length and weight. Reduced maternal or placental lactogen signals and lower placental 11β-HSD2 activity clustered with placental insufficiency and fetal growth restriction, while diabetic pregnancies showed a shift toward adiposity-related outcomes. In extreme prematurity, abrupt loss of placental endocrine support created a translational window in which rhIGF-1/rhIGFBP-3 replacement emerged as the clearest mechanism-based intervention, although current clinical evidence remains preliminary. Conclusion: Placental endocrine markers should not be used as standalone screening tools. Their main value at present is mechanistic and translational: combined hormone patterns may refine biological understanding and risk stratification within defined maternal and neonatal disease frameworks, while IGF-1 replacement in extreme prematurity represents the most credible current therapeutic lead.
To evaluate instability during gait and their determinants in ASD patients. 123 ASD patients and 42 controls underwent biplanar radiographs with calculation of spinopelvic and global alignment parameters, and performed 3D gait analysis to calculate full-body kinematics. They all filled the SF-36 with its physical component (PCS). The frontal and sagittal Center of Mass-Center of Pressure (CoM-CoP) angles were calculated during the gait cycle. Patients were classified as ASD-unstable or ASD-stable based on the corridor of normality of the CoM-CoP angle. Kinematics, radiographic parameters and PCS were compared between groups. All ASD patients had a normal CoM-CoP angle in the sagittal plane. 38 ASD were classified as unstable in the frontal plane and 85 as stable (14 ± 3° vs 8 ± 2° resp., p < 0.001). While the 2 groups had a similar pelvic incidence (PI = 53°), ASD-unstable patients had an increased SVA (69 vs 20 mm), and global tilt (GT: 33 vs 24°, all p < 0.05), compared to ASD-stable. The frontal Cobb was similar between the 2 groups (Cobb = 17°). ASD-unstable also had an increased sagittal kinematic ODHA (10 vs 6°), and a decreased normalized step length (0.30 vs 0.34, both p < 0.05). They also had a decreased PCS (33 vs 37). ASD patients with increased global sagittal malalignment (SVA GT) appear to have increased frontal instability during gait. Frontal instability during gait was associated with kinematic limitations in the sagittal plane and deterioration in quality of life. Future work will focus on changes in gait stability in ASD patients after corrective spinal malalignment surgery.
Clinicians assessing trauma patients are routinely faced with the critical question of when to pursue whole-body computed tomography (WBCT) and when to withhold it to limit unnecessary exposure and resource use. Despite its widespread integration into early trauma care, there remains uncertainty about the best approach for selecting patients for WBCT, particularly given the implications of its findings. We aimed to evaluate the clinical characteristics and outcomes of trauma patients with positive (pWBCT) versus negative (nWBCT) findings. A retrospective study of adult trauma patients who underwent WBCT imaging in 2021 and 2022 was conducted. Patients were stratified into pWBCT; at least one acute traumatic injury identified on scan from head to pelvis or nWBCT; no acute traumatic injury detected on scan from head to pelvis. Clinical characteristics, mechanisms of injury, injury severity, Trauma activation level, and outcomes were analyzed. Multivariable logistic regression analysis was performed to identify independent predictors of pWBCT at presentation. A total of 2,555 patients were included (76.8
