Herzen University, or formally the Russian State Pedagogical University in the name of A. I. Herzen (Russian: Российский государственный педагогический университет имени А. И. Герцена) is a university in Saint Petersburg, Russia. It was formerly known as the Leningrad State Pedagogical Institute. It is one of the largest universities in Russia, operating 20 faculties and more than 100 departments. Embroidered in its structure are the Institute of Pre-University Courses, the Institute of Continuous Professional Development, and the Pedagogical Research Center.The university is named after the Russian writer and philosopher Alexander Herzen..
It is shown that nonzero asymptotic nonadiabatic couplings of molecular states are a fundamental property of the standard Born–Oppenheimer approach to studying inelastic processes in collisions of atoms and/or ions. The given connections provide the correct boundary conditions for radial nuclear wave functions. It is also shown that failure to take into account nonzero asymptotic relations leads to physical artifacts. The solution to these problems is achieved by applying the reprojection method, which considers nuclear dynamics in the asymptotic regions before and after the collision in the representation of scattering channels and in the interaction region in the representation of molecular states.
Background: Traditional football teaching in school physical education often emphasizes technical drills and skill repetition, which can lead to reduced student engagement and limited development of tactical understanding. Game-Based Learning (GBL), particularly through the Teaching Games for Understanding (TGfU) model, offers an alternative approach that prioritizes tactical awareness and decision-making within authentic game contexts. Purpose: This quasi-experimental study examined the effectiveness of a GBL approach in improving tactical understanding and intrinsic motivation among secondary school students in football physical education classes in Kabupaten Dompu, Nusa Tenggara Barat, Indonesia. Methods: Eighty-four students (mean age = 14.6 ± 1.2 years; 52 males, 32 females) from two secondary schools participated in an 8-week intervention (16 sessions, 2×/week). The experimental group (n=42) received GBL-based instruction using modified small-sided games and tactical questioning, while the control group (n=42) followed traditional skill-drill methods. Tactical understanding was assessed using the Game Performance Assessment Instrument (GPAI), and motivation was measured using the Sport Motivation Scale (SMS) adapted for physical education. Data were analyzed using paired t-tests, ANCOVA, and Cohen's d effect sizes. Results: The GBL group demonstrated significantly greater improvements in tactical understanding (decision-making: 42.3%; skill execution: 31.8%; support: 38.5%) compared to the control group (15.2%, 18.4%, 12.7% respectively; all p < 0.001). Regarding motivation, the GBL group showed significant increases in intrinsic motivation (d = 1.24, p < 0.001), identified regulation (d = 0.89, p < 0.001), and decreased amotivation (d = -1.02, p < 0.001), while the control group showed minimal changes. ANCOVA revealed significant between-group differences favoring GBL on all measures (F-values ranging from 32.45 to 58.72, all p < 0.001, partial η² = 0.28-0.42). Conclusions: The GBL approach using TGfU principles significantly enhanced both tactical understanding and autonomous motivation in secondary school football education. These findings support the implementation of game-centered pedagogies in Indonesian physical education contexts and suggest that GBL may address common challenges of student disengagement in traditional skill-focused instruction. Future research should explore long-term retention effects and implementation across diverse cultural and educational settings.
A hybrid quantum model is introduced for low-energy ion/atom-hydrogen collisions. The model integrates ab initio calculations for low-lying states with asymptotic fitting for highly excited states, enabling fully quantum mechanical dynamics calculations that capture radial and rotational couplings across all internuclear distances, thereby addressing limitations of Landau-Zener models, which neglect short-range nonadiabatic interactions. Applied to the NaH system, the results for both mutual neutralization and excitation processes align well with fully quantum mechanical benchmarks for dominant channels. The analysis reveals the dominance of long-range ionic-covalent interactions for large cross sections and the significant influence of rotational coupling above 10 eV/u. Furthermore, discrepancies in weak excitation channels highlight the critical role of short-range non-adjacent couplings, which are often neglected in simplified models. This framework provides a robust tool for astrophysical non-local thermodynamic equilibrium modeling, thereby improving the accuracy of stellar abundance analyses.
The relevance of this study is related to the linguistic-cultural potential of vocabulary with an ethnic meaning, having complex systemic characteristics and implicit culturally marked content, that should be included in teaching Russian to foreign students. The study is aimed at identifying and describing the linguistic-cultural potential of vocabulary with an ethnic component for teaching Russian to foreign students based on lexicographic sources. The main methods used in the study are lexicographic, semantic, quantitative, associative, and interpretative analysis of vocabulary. The study material was a corpus of lexical means with an ethnic meaning (more than 400 units in general totality) collected with a continuous sampling from academic explanatory, semantic, and ideographic dictionaries of the Russian language and coordinated with the “Lexical Minimum in Russian as a Foreign Language. II Certification Level” (select collection). The authors established that vocabulary with an ethnic component is a complex structure, including anthroponyms, ethnonyms, and words with the same root; it contains systemic, connotative, associative and evaluative, background, and idiomatically conditioned culturally marked information. The study demonstrates that the linguistic-cultural potential of this vocabulary must be considered when teaching Russian to foreign students. The research prospects include the creation of a comprehensive educational dictionary “Russian Vocabulary with an Ethnic Component”.
Human cytomegalovirus (HCMV) remains a significant cause of morbidity in immunocompromised patients, necessitating the development of improved antivirals. Using an integrated in silico and in vitro approach, we identified a novel ligand (NL) as a letermovir analog with enhanced binding affinity and reduced cytotoxicity. A pUL56 terminase subunit model generated with AlphaFold 3 was used for the virtual screening of a 15,000-compound library. Among the 73 candidates with structural similarity to letermovir (Tanimoto ≥ 0.6), NL exhibited superior predicted binding affinity (ΔGbind = −10.7 kcal/mol). In silico toxicity prediction (ProTox 3.0) classified NL as having low toxicity (class 4, LD50 ≈ 1000 mg/kg), which was confirmed in vitro, where NL demonstrated 158-fold less toxic (CC50 = 2.69 mg/mL) in MRC-5 cells than letermovir (0.017 mg/mL). Molecular dynamics simulations over 500 ns revealed that the pUL56-NL complex forms a more thermodynamically stable interaction, with a lower calculated free energy of binding (MMGBSA: −40.89 ± 7.40 kcal/mol vs. −32.76 ± 4.96 kcal/mol) and a narrower free energy landscape. These results establish NL as a promising, low-cytotoxicity candidate with enhanced target engagement, warranting further investigation as a potential anti-HCMV therapeutic.
