Hue University of Medicine and Pharmacy

The association between body weight and vertebral fracture is established, but whether muscle mass or fat mass drives this relationship remains unclear. In Vietnamese adults, our study demonstrates that muscle mass, rather than fat mass, predicts vertebral fracture risk. Both low and excessive muscle mass significantly increase this risk, indicating a U-shaped relationship. The purpose is to examine the relationship between various body composition measures and vertebral fracture in a Vietnamese population. This cross-sectional study included 1,372 Vietnamese adults aged ≥ 50 years from the Vietnam Osteoporosis Study. Body composition was measured using dual-energy X-ray absorptiometry to derive lean body mass index (LBMI), appendicular skeletal muscle mass index (ASMI), body fat mass index (BFMI), and percentage-based indices. Vertebral fractures were identified via thoracolumbar radiographs using Genant’s semiquantitative method. Adjusted logistic regression models and restricted cubic splines were used to assess associations and explore nonlinear relationships. Vertebral fractures were diagnosed in 173 participants (12.6

Background:Liver fibrosis is a significant health burden in Vietnamese male adults, driven by high rates of hepatitis B and hepatitis C, excessive alcohol consumption, and genetic and environmental factors. Despite progress in diagnostic tools, there is a pressing need for cost-effective screening methods tailored to this high-risk group, particularly in resource-limited settings. Methods:This study enrolled 952 Vietnamese male adults over 40 years old undergoing FibroScan, excluding those with conditions affecting test accuracy. Data on demographics, clinical history, and anthropometrics were collected, and fibrosis stages were classified using the METAVIR system. Model development combined Bayesian model averaging and forward stepwise methods, with predictive performance validated via receiver operating characteristic (ROC) analysis and area under the curve (AUC) estimation in the R environment. Results:Among 952 male participants, the prevalence of liver fibrosis was 19.9%, with most cases classified as mild (F1). Multivariate analysis identified significant risk factors, including advanced age (odds ratio (OR) = 1.6; 95% confidence interval (CI) [1.02-2.51]), alcohol abuse (OR = 4.44; 95% CI [2.65-7.42]), hepatitis B (OR = 6.76; 95% CI [3.14-14.54], hepatitis C (OR = 33.04; 95% CI [5.26-207.42]), family history of cirrhosis (OR = 16.14; 95% CI [3.28-79.55]), and hepatic steatosis (OR = 4.02; 95% CI [2.57-6.28]). The predictive model demonstrated good discriminative performance with an AUC of 0.769 (95% CI [0.734-0.800]) and showed satisfactory calibration through bootstrap resampling, indicating close agreement between predicted and observed risks. Conclusion:The current prevalence of liver fibrosis among Vietnamese male adults was found to be 19.9%, and the developed risk prediction model effectively identifies high-risk individuals, enabling early diagnosis and targeted prevention, particularly in resource-limited settings. However, the lack of external validation and the sample restricted to Vietnamese male adults limit the generalizability of the model, which should be further evaluated in other populations.

The extracellular polymeric substance (EPS) matrix serves as a structural scaffold for biofilm organization, contributing to structural integrity and antimicrobial tolerance by modulating the penetration and distribution of antimicrobial agents. However, whether this EPS matrix can also potentiate antimicrobial localization and activity remains poorly understood. Here, we investigated the role of the EPS matrix in erythrosine B (EB)-mediated killing of Streptococcus mutans within mature biofilms under short-contact topical treatment conditions. Biofilms formed on saliva-coated hydroxyapatite discs were exposed to brief EB treatment. EB rapidly reduced viable bacteria in mature biofilms and markedly suppressed glycolytic acid production. Confocal imaging revealed preferential localization of EB within EPS-rich regions of intact biofilms, whereas enzymatic matrix disruption significantly reduced EB-associated fluorescent signals. Consistently, disruption or absence of the EPS matrix markedly attenuated EB-mediated bacterial killing, demonstrating that matrix integrity is required for its antimicrobial efficacy. These findings identify a matrix-dependent antimicrobial mechanism in which EPS architecture influences EB localization and enhances bactericidal activity in mature biofilms. This work challenges the conventional view of the biofilm matrix solely as a protective barrier and highlights its broader role as a functional determinant of antimicrobial performance in mature biofilms.

Mục tiêu: Xác định tỷ lệ viêm nội mạc tử cung mạn tính (VNMTCMT) và đánh giá kết quả có thai ở bệnh nhân (BN) mắc và không mắc bệnh lý này thực hiện thụ tinh trong ống nghiệm. Đối tượng và phương pháp nghiên cứu: Nghiên cứu tiến cứu, theo dõi dọc trên 103 BN thực hiện thụ tinh trong ống nghiệm tại Bệnh viện Phụ sản Hải Phòng từ 8/2024 đến 8/2025. VNMTCMT được chẩn đoán dựa trên nhuộm hóa mô miễn dịch CD138 (≥5 tế bào/10 vi trường). Các BN được chia thành nhóm mắc và không mắc. Nhóm mắc bệnh được điều trị kháng sinh trước chuyển phôi. So sánh kết quả có thai giữa hai nhóm. Kết quả: Tỷ lệ VNMTCMT là 37.9% (39/103). Không có sự khác biệt có ý nghĩa thống kê giữa hai nhóm về đặc điểm chu kỳ thụ tinh trong ống nghiệm và đặc điểm chuyển phôi (p > 0.05). Tỷ lệ có thai ở nhóm VNMTCMT sau điều trị cao hơn nhóm không mắc (71.1% so với 55.7%), tuy nhiên chưa có ý nghĩa thống kê (p > 0.05). Tỷ lệ thai lâm sàng và thai tiến triển ở nhóm VNMTCMT sau điều trị lần lượt là 68,4% và 60.5%, cao hơn có ý nghĩa thống kê so với nhóm không mắc (47.5% và 39.3%) với p = 0.04. Phân tích theo mức độ bệnh cho thấy nhóm viêm nhẹ (5≤CD138<10) có kết quả thai kỳ cao nhất. Kết luận: Bệnh lý VNMTCMT chiếm tỷ lệ đáng lưu ý trong nhóm BN vô sinh làm thụ tinh trong ống nghiệm. Việc sàng lọc và điều trị trước chuyển phôi có thể cải thiện kết quả thụ tinh trong ống nghiệm, đặc biệt là tỷ lệ thai lâm sàng và thai tiến triển

Introduction: Recurrent carpal tunnel syndrome (CTS) is commonly attributed to incomplete decompression or perineural scarring. However, delayed-onset ulnar nerve compression at Guyon’s canal after carpal tunnel release (CTR) is extremely rare and presents diagnostic and therapeutic challenges. Case report: We report the case of a 50-year-old man who developed dual neuropathies, recurrent median nerve compression, and new-onset ulnar nerve entrapment, approximately one year after open CTR. He presented with diffuse hand paresthesia, weakness, ulnar digit clawing, and impaired thumb opposition. Electrodiagnostic studies revealed severe axonal damage in both the median and ulnar nerves. Surgical intervention was performed via a single palmar incision, including dual nerve decompression, epineurolysis, hypothenar fat pad grafting, and opponensplasty using the extensor indicis proprius (EIP) tendon. At one-year follow-up, the patient demonstrated full sensory recovery, regained thumb opposition, improved grip and pinch strength, and no recurrence of symptoms. Conclusion: This case highlights the importance of comprehensive clinical and electrodiagnostic reassessment in patients with recurrent or evolving symptoms after CTR. A single-stage, integrated surgical approach may constitute a viable management option in carefully selected patients with complex dual nerve entrapments and is presented as an illustrative example for comparable challenging clinical situations.