Huta Stalowa Wola (HSW SA) is a defense contractor and steel mill located in Stalowa Wola, Poland. It is a major producer of military equipment..
Alzheimer's disease (AD) remains one of the greatest challenges in modern medicine, serving as the leading cause of dementia in the elderly. Despite decades of research, effective causal treatment is still not available, and current therapies mainly focus on alleviating symptoms. However, in recent years, there has been significant progress in therapies targeting pathological proteins – amyloid β (Aβ) and tau – offering hope for modifying the course of the disease. In this review, we discuss the latest achievements in AD treatment, including clinical trial results involving monoclonal antibodies (lecanemab, donanemab), the role of biomarkers in early diagnosis, and the impact of non- pharmacological interventions such as diet and physical activity. Additionally, we analyze the challenges associated with anti-amyloid therapy, including side effects and limitations of current methods. We also emphasize the importance of personalized medicine and future research directions that may lead to breakthroughs in Alzheimer's disease therapy. Materials and methods: This review was conducted systematically to identify and analyze relevant scientific literature regarding advancements in the treatment and diagnosis of Alzheimer's disease. The PubMed database was searched. Articles were searched using the following words: "Anti-amyloid therapies"; "Alzheimer's disease"; "Lekanemab"; "Donanemab"; "Alzheimer's biomarkers"; "Cerebrospinal fluid"; "CSF"; "Tau protein"; "Non- pharmacological interventions"; "Mediterranean diet"; "Dementia prevention"; "Amyloid- related imaging abnormalities"; "Disease-modifying therapies”; „traumatic brain injury”.
The study focuses on analyzing the interior surfaces of the component responsible for directing projectiles during discharge. This investigation involves a detailed assessment of the chamber's internal condition, aiming to uncover any signs of wear, erosion, or deformation that could impact performance and safety of use. In the study, results from surface analysis of cut fragments taken from eight selected locations of the examined object were utilized. The samples were scanned using the ATOS Compact Scan 5M portable 3D scanner. Subsequently, a geometric model of the sample’s surface was created using CAD software and compared with the scan data through ATOS Professional software. The resulting surface maps enabled the evaluation of the scale of erosion on the sample surfaces and facilitated the analysis of the destructive mechanisms occurring during the object’s operation. Surface roughness measurements were conducted on 2x2 mm areas of the samples using a Hommel-Etamic T8000RC stationary profilometer. According to ISO 25178, three-dimensional surface maps were obtained, allowing for a detailed description of surfaces condition and the mechanisms occurring at the analyzed areas . The evaluation employs advanced imaging SEM, EDS and measurement techniques to ensure a comprehensive understanding of the structural integrity and functional state of this crucial element in the armament assembly.
Introduction and aim: Paracetamol (acetaminophen) is a commonly used analgesics and antipyretics and it is a nonprescription medicine. Improper use of it may lead to accidental or intentional poisoning. The aim of the study was to analyse paracetamol poisonings in children and adolescents admitted to the Clinical Department of Toxicology and Cardiology in Stefan Wyszyński Regional Specialist Hospital in Lublin in 2022. Material and methods: The research was retrospective. Medical records of poisoning cases in patients up to the age of 18 were analysed specifically emphasizing acetaminophen poisonings.Results: In the studied period 120 adolescents were hospitalized due to intoxication, 65 of them due to medications intake, the most commonly used medicine was acetaminophen. There were 20 cases of hospitalization because of acetaminophen intake, 17 (85%) patients were female and 3 (15%) of them were male. Patients were from 15 to 17 years old. In 12 cases (60%) patients came from urban areas. The intentional intoxications were found in 18 (90%) cases, 13 of them were suicide attempt. Majority of cases of attempted suicide were female (92%). The other intoxications were accidental, where patients took acetaminophen as a painkiller. In the researched group there were no deaths.Conclusions: Paracetamol overdosing is always associated with the risk of liver damage.This medicament as a potentially hepatotoxic drug should not be sold over the counter. The availability of paracetamol is too widespread, which poses a risk especially to children and adolescents. The ubiquitous advertising of acetaminophen products as well as their popular use, for example, in menstrual pain, favor their presence in almost every Polish home. Parents and guardians should be educated about the dangers of uncontrolled use of so-called OTC drugs - incorrectly commonly considered safe.
Introduction and purpose: Poisoning among children and adolescents is occurring on an ever-increasing scale. Women are particularly susceptible to intentional poisoning, and they predominate in the statistics of self-poisoning. The aim of the study is to analyze cases of poisoning in girls under 18 years of age hospitalized in the Clinical Toxicology and Cardiology Department of the Stefan Cardinal Wyszynski Regional Hospital in Lublin in 2022, taking into account the type of substance ingested, the place of residence of the patients and comorbidities.Material and methods: The study was retrospective in nature. It used the analysis of medical records of 84 cases of intoxication in girls under 18 years of age.Results: During the time period studied, 84 girls aged 13-18 were hospitalized for poisoning. Most of the cases were urban residents (64.3%). The toxic substances causing poisoning were mainly drugs (63.1%), narcotics (17.9%) and ethanol (17.8%). Poisoning of an intentional nature involved 80 (95.2%) cases, 37 (44%) cases were suicide attempts. In 54 (64.3%) cases, the patient was burdened with a mental illness, the most common being depressive disorders. There were no deaths in the study group.Conclusions: Due to the increasing phenomenon of mental disorders, as well as intentional poisoning among adolescent girls, special emphasis should be placed on psychological care, pedagogical care, of girls in adolescence. This is the time when girls have problems with acceptance of their bodies, with acceptance among peers. Parents and teachers should be made aware of this.
In this paper, the experimental investigations, constitutive description and numerical modelling of low-cycle fatigue behaviour of P91 steel in non-isothermal conditions are presented. First, experimental tests are performed to recognise different aspects of material behaviour. Then, an appropriate constitutive model is developed within the framework of thermodynamics of irreversible processes with internal state variables. The model describes two phases of cyclic softening, related to plastic mechanisms. An important goal of the presented research is to include thermomechanical coupling in the constitutive modelling. Next, the model parameters are identified based on the available experimental data. Some parametric studies are presented. Finally, numerical simulations are performed, which indicate the significant influence of thermomechanical coupling on the response of the constitutive model in thermomechanical fatigue conditions.
