The advent of new high-resolution mass spectrometry has opened new important frontiers especially in the profile analysis of molecular complex mixture. In fact, it is now possible to analyze thousand of molecular species per analysis. One of the most employed technique for this porpoises is Liquid Chromatography – Mass Spectrometry. Recently, the SANIST technological platform based on this technique integrated with Surface Activated Chemical Ionization/Electrospray (SACI/ESI) and a data elaboration system for compounds identification performed on the basis of EU directive (EU directive 2002/657/EC) has been developed. This technique provide benefits in terms of sensitivity increase due to the SACI/ESI ionization source and in the compounds identification precision increase that is performed by means of spectrum match criteria recognized by EU legislation. This technology can be used to check the composition quality in different fields: food, pharmacological and environmental. A SANIST limitation is that the existing methods makes possible to analyze low and medium/high molecular weight compounds only separately. Here we present a SANIST-CIMS approach that makes used of the in source Cloud Ion Mobility effect produced in SACI/ESI device to simultaneously analyze low and medium/high molecular weight compounds in a single run so to increase the throughput in the field of product control. The data obtained analyzing the qualitative composition of some commercial product has been shown and disclosed.
