Despite advanced analytical methods and increasing data availability, most intensive care unit (ICU) prediction models rely on static measurements. However, longitudinal monitoring of biomarkers may better capture disease progression and support timely, individualized interventions within the framework of predictive, preventive, and personalized medicine (PPPM). Since the COVID-19 pandemic, interest in both static and dynamic modelling has expanded. Therefore, this review aimed to summarize current evidence on the use of longitudinal blood biomarker data in ICU prediction models, assess how the pandemic shaped this research, and report validation strategies. This scoping review followed the PRISMA-ScR guidelines. PubMed and Google Scholar were searched for studies on blood biomarker trajectory analysis in the ICU published between 2014 and 2025, covering five years before and after the onset of the COVID-19 pandemic. Forty-seven studies were included, mainly from North America (47
In this work, three distinct systems of two linearly coupled maps are investigated, motivated by modeling considerations from the social sciences, broadening previously studied formulations. Numerical simulations are carried out using logistic maps, where, beyond synchronization zones, additional relevant zones are identified, corresponding to fixed-point and period-2 behaviors, as well as phenomena associated with certain transitions between chaotic and periodic dynamics. The study also establishes analytical results, some of which hold for classes of maps beyond the logistic family. A comparative analysis of the three systems is presented, highlighting similarities and differences in the structure of the identified zones and in the observed dynamical phenomena.
The stability of tree-level relations among the parameters of a quantum field theory with respect to renormalization group (RG) running is typically explained by the existence of a symmetry. We examine a toy model of a quantum field theory of two real scalars in which a tree-level relation among the squared-mass parameters of the scalar potential appears to be RG-stable without the presence of an appropriate underlying symmetry. The stability of this relation with respect to renormalization group running can be explained by complexifying the original scalar field theory. It is then possible to exhibit a symmetry that guarantees the relations of relevant beta functions of squared-mass parameters of the complexified theory. Among these relations, we can identify equations that are algebraically identical to the corresponding equations that guarantee the stability of the relations among the squared-mass parameters of the original real scalar field theory where the symmetry of the complexified theory is no longer present.
Recently, a hitherto unknown class of renormalization group stable relations between parameters of bosonic field theories has been identified and dubbed as the r0 or "GOOFy" symmetries. Here, one-loop properties of the r0 invariant two-Higgs doublet model and a minimal symmetric model are discussed. It is concluded that the symmetry is present at the one-loop provided the UV cutoff squared transforms nontrivially under r0. The minimal model requires the presence of two real fields.
We provide a study of the parameter space of the complex 2-Higgs Doublet Model (C2HDM), focusing on signs of large CP-violating couplings of the 125 GeV Higgs boson with the fermions. The study is performed utilizing Machine Learning (ML) techniques developed recently for parameter space exploration, including an Evolutionary Strategy Algorithm and Novelty Reward. We give particular attention to the electron electric dipole moment (eEDM). We confirm that the recently found kite diagrams are crucial for the outcome of the analysis. Moreover, their use also mitigates the dependence of the results on the scale and scheme choice of the masses in the loop diagrams. We furthermore point out that, already at the current level of experimental precision, the Barr-Zee diagrams with charm quark loops must be taken into account. The combined use of kite diagrams and ML techniques allows for the resurrection of large fermion CP-odd couplings for Type-II and Flipped C2HDM when the 125 GeV Higgs coincides with the second lightest neutral scalar. This arises due to cancellations, typically of the per-mil order, which, moreover, will still be possible for a foreseeable eEDM precision down to 10^-33 e.cm. For these cases, the constraints on the CP-odd couplings arises from the precision LHC measurements.
