Kitasato University (北里大学, Kitasato Daigaku) is a private medical university headquartered in Shirokane, Minato, Tokyo, Japan. The head of the university is on the Shirokane campus, neighboring the original Kitasato Institute, the first private medical research facility in Japan which was the starting point for the university in its present form. Kitasato University is ranked by Times Higher Education among the 350 best universities in Asia.
Pasteurella multocida is an important zoonotic pathogen that can cause human infections, exhibiting a wide clinical spectrum ranging from localised bite-wound infections to invasive infections, particularly in immunocompromised patients. The detection of P. multocida isolates from three patients with severe motor and intellectual disabilities (SMID) led to an investigation into the genomic relationship to explore nosocomial transmission. Three P. multocida strains were isolated from transtracheal aspirate cultures taken from three different inpatients in the SMID ward between January and February 2025. All strains were identified by phenotypic tests and MALDI-TOF MS. Whole-genome sequencing was performed to identify subspecies, analyze virulence genes, and explore phylogenetic relatedness. Three strains were identified as P. multocida subsp. gallicida, based on dDDH values of 89.6
In this study, we investigated the diagnostic performance of magnifying endoscopy (ME) with third-generation narrow-band imaging (3G-NBI) for early gastric cancer (EGC), primarily in patients with Helicobacter pylori eradication. This was a post hoc analysis of a multicenter, randomized trial comparing 3G-NBI, texture and color enhancement imaging, and white-light imaging in gastric neoplasm (GN) detection. For all detected lesions, the endoscopic diagnosis of ME using 3G-NBI was compared with the pathological diagnosis. The primary analyses focused on the sensitivity and specificity of ME with 3G-NBI for EGC or non-EGC. The diagnostic performance was analyzed according to confidence level, macroscopic type, lesion size, and H. pylori infection status. This study included 901 patients; 228 suspected GN lesions in 187 patients were analyzed. The lesions were diagnosed with EGC in 62 (27 with high confidence) and non-EGC in 166 (91 with high confidence) patients using ME with 3G-NBI and pathologically diagnosed as EGC in 61 and non-EGC in 167 patients. The overall diagnostic performance was sensitivity and specificity of 70.5
There are concerns regarding postoperative infections following laparoscopic colectomy with intracorporeal anastomosis. Thus, in this study, we aimed to determine the optimal preoperative bowel preparation to reduce postoperative infectious complications in patients undergoing laparoscopic colectomy with intracorporeal anastomosis. This secondary analysis of the ICAN study—a multicenter, retrospective cohort study involving 46 institutions affiliated with the Japan Society of Laparoscopic Colorectal Surgery—included 615 patients with colon adenocarcinoma undergoing laparoscopic colectomy with intracorporeal anastomosis between January 2020 and December 2021. Patients were analyzed after applying eligibility criteria and propensity score matching based on age ≥ 65 years, sex, body mass index ≥ 30, American Society of Anesthesiologists Physical Status, diabetes, and the number of intracorporeal anastomosis cases previously performed at the institution. Among them, 312 received combined oral antibiotics and mechanical bowel preparation, whereas 156 received other preparations (mechanical preparation alone, oral antibiotics alone, and no preparation). The primary outcome was surgical wound infection incidence (Clavien–Dindo grade ≥ II) at initial discharge. Secondary outcomes included intraperitoneal infections, anastomotic leakage, ileus, and postoperative hospital stay. Surgical wound infection (1/312 [0.3
Familial lecithin–cholesterol acyltransferase deficiency (FLD) is a rare hereditary disorder. In FLD, a clinical triad of corneal opacity, anemia, and proteinuria typically precedes progressive renal dysfunction. Although early renal involvement has been widely described, there are limited reports on the long-term course leading to dialysis initiation, including systemic complications. We present a genetically confirmed case of FLD caused by the Cys74Tyr mutation, which had a clinical course exceeding 10 years with the emergence of multisystem complications. The patient initially showed a transient stabilization of renal function following a fat-restricted and protein-restricted diet and renin–angiotensin system blockade; however, subsequent decline occurred despite continued management. During this deterioration phase, systemic complications emerged, including progressive aortic valve stenosis, complete atrioventricular block, heart failure, and cerebellar infarction, in close temporal association with worsening renal function. Hemodialysis initiation led to rapid resolution of erythropoietin-resistant anemia, which may be attributable to the improvement in the uremic milieu following dialysis initiation. This case offers valuable insights into the late-stage progression of FLD. The observations may help determine the point at which renoprotective and metabolic interventions become less effective. Furthermore, the temporal association between renal deterioration and the development of cardiovascular and neurovascular complications suggests the need for careful clinical surveillance during advanced stages of renal dysfunction.
We investigate the chiral soliton lattice (CSL) in the framework of holographic QCD in magnetic field. Under appropriate boundary conditions for the gauge field and the quark mass deformation, we demonstrate that the ground state in the gravitational dual of QCD is given by the CSL in the background magnetic field and the baryon number density. In the presence of the background magnetic field, we show that the CSL is interpreted as a uniformly distributed D4-branes in the holographic setup, where the chiral soliton is identified with a non-self-dual instanton vortex or a center vortex in the five dimensional bulk gauge theory. While the baryon numbers are given to chiral solitons as well as Skyrmions due to the different terms in the Wess-Zumino-Witten (WZW) term in the chiral perturbation theory, these baryon numbers with different origins are unified in terms of the instanton charge density in five dimensions. With bulk analysis of the WZW term, we find that the pion decay constant becomes dependent on the magnetic field. For the massless pion case, we obtain an analytical form that is in qualitative agreement with lattice QCD results for strong magnetic fields.
