Louis Pasteur University (Université Louis-Pasteur), also known as Strasbourg I or ULP was a large university in Strasbourg, Alsace, France. As of 15 January 2007, there were 18,847 students enrolled at the university, including around 3,000 foreign students. Research and teaching at ULP concentrated on the natural sciences, technology and medicine. On 1 January 2009, Louis Pasteur University became part of the refounded University of Strasbourg and lost its status as an independent university.The university was a member of the LERU (League of European Research Universities). It was named after the famous 19th-century French scientist Louis Pasteur. Nineteen Nobel laureates and two laureates of the Fields Medal have studied, taught or conducted research at Louis Pasteur University, underlining the excellent reputation of the university..
In the limit of vanishing up, down and strange quark masses, QCD exhibits a chiral symmetry. This symmetry is broken spontaneously to its vector subgroup, giving rise to Goldstone bosons. These acquire a small mass through the explicit chiral symmetry breaking for non-vanishing quark masses. The consequences of these broken symmetries can be investigated in a suitably tailored effective field theory called chiral pertubation theory. It admits a perturbative expansion in the external momenta and the Goldstone boson masses and can be systematically analyzed in terms of a loop expansion. The appearing ultraviolet divergences in loop diagrams can be dealt with order-by-order through the Goldstone boson contact interactions. Matter fields like the lowest-lying baryons can also included, leading to a rich and testable phenomenology of low-energy QCD.
The third Critical Assessment of Computational Hit-finding Experiments (CACHE) challenged computational teams to identify chemically novel ligands targeting the macrodomain 1 of SARS-CoV-2 Nsp3, a promising coronavirus drug target. Twenty-three groups deployed diverse design strategies to collectively select 1739 ligand candidates. While over 85% of the designed molecules were chemically novel, the best experimentally confirmed hits were structurally similar to previously published compounds. Confirming a trend observed in CACHE #1 and #2, two of the best-performing workflows used compounds selected by physics-based computational screening methods to train machine learning models able to rapidly screen large chemical libraries, while four others used exclusively physics-based approaches. Three pharmacophore searches and one fragment growing strategy were also part of the seven winning workflows. While active molecules discovered by CACHE #3 participants largely mimicked the adenine ring of the endogenous substrate, ADP-ribose, preserving the canonical chemotype commonly observed in previously reported Nsp3-Mac1 ligands, they still provide novel structure-activity relationship insights that may inform the development of future antivirals. Collectively, these results show that multiple molecular design strategies can efficiently converge on similar potent molecules.
Conventional laparoscopic instrument exchange requires repeated trocar withdrawal, redirecting surgeon gaze and disrupting operative flow. The Symphera system enables intracorporeal tool-tip switching, but its impact on procedural efficiency, visual attention, and workload has not been evaluated in a controlled setting. Two surgical fellows performed three standardised laparoscopic tasks (cholecystectomy, controlled hepatic bleeding, dissection–coagulation relay) under Symphera and conventional conditions in a live porcine crossover model. Primary outcomes were total task time and tool change time; secondary outcomes included gaze behaviour (eyes-on proportion, disruption events), subjective workload (SURG-TLX), device usability, and heart rate. Mean total task time was 27.3 ± 10.9 vs. 33.9 ± 13.2 min (−19.6
Introduction: The increase in the population of immunocompromised patients due to advances in management of end-stage diseases and transplants poses challenges in treating infections caused by multi-drug resistant (MDR) pathogens. Cefiderocol (FDC), a siderophore cephalosporin, has shown efficacy against carbapenem-resistant Gram-negative bacteria. Methods: This retrospective multicentre study investigated the real-world use of FDC in 114 immunocompromised adults treated for MDR infections in 12 French hospitals (June 2020-November 2023). Clinical and microbiological outcomes, including infection cure, relapse, as well as mortality, and resistance acquisition, were assessed at days 28 and 90. Antibiotic prescription compliance with current guidelines was investigated. Results: At day 28, clinical success was achieved in 53.3% of cases, and overall mortality was 37.7%, consistent with other studies (33-37%). Infection-related mortality accounted for 25.4%. Relapse occurred in 17.5% of patients by day 28, rising by an additional 9.8% among survivors by day 90. Resistance acquisition was observed in two cases at day 28 ( Pseudomonas aeruginosa and Stenotrophomonas maltophilia) and in three additional cases by day 90. FDC was used as monotherapy in 49.1% of cases, with a median treatment duration of 10 days. Nearly 25% of strains collected in FDC-treated patients were susceptible to best-practice alternatives. Conclusion: These findings highlight FDC's utility in difficult-to-treat infections, particularly S. maltophilia, but the high relapse rate and resistance acquisition underscore the need for careful monitoring, adherence to guidelines, and reconsideration of empirical use to prevent resistance and improve outcomes in fragile populations. (c) 2024 The Author(s). Published by Elsevier Ltd on behalf of The British Infection Association. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
