Mayo Clinic Florida is a comprehensive medical center belonging to the Mayo Clinic in Jacksonville, Florida. It is one of three Mayo campuses along with Phoenix/Scottsdale, Arizona and Rochester, Minnesota.Mayo's campus is situated on 400 acres located near the intersection of San Pablo Road and J. Turner Butler Boulevard, an expressway which serves as a major thoroughfare to and from the Jacksonville Beaches.
BACKGROUND:Progressive supranuclear palsy (PSP) is a tauopathy for which there is limited understanding of epidemiological risk factors. OBJECTIVE:The objective of this study was to identify premorbid nonmedical and medical risk factors for PSP diagnosis in a large prospective population-based cohort. METHODS:We performed a matched nested case-control study using the UK Biobank (UKB) cohort consisting of >500,000 adults aged 37 to 73 years. PSP diagnoses were identified from 2007 to censor date (August 2025) and matched 1:10 by age and sex to control subjects without parkinsonism or dementia diagnoses. We derived risk factors using an iterative logistic regression approach. RESULTS:There were 240 incident PSP diagnoses in the UKB. In the fully adjusted model, premorbid depression (odds ratio [OR], 3.22; 95% confidence interval [CI], 2.30-4.50; P < 0.001), delirium (OR, 6.76; 95% CI, 4.08-11.19; P < 0.001), and functional gastrointestinal disorders (OR, 1.91; 95% CI, 1.39-2.63; P < 0.001) were associated with increased risk. Heavy alcohol consumption was associated with higher risk compared with moderate consumption (OR, 1.65; 95% CI: 1.21-2.26; P = 0.0017). Body mass index (BMI) and alcohol consumption had nonlinear risk profiles. Cancer diagnosis was inversely associated with PSP (OR, 0.56; 95% CI, 0.40-0.79; P < 0.001). Depression and delirium diagnoses remained significant 5 to 10 years before diagnosis. CONCLUSIONS:In this large prospective cohort, PSP was associated with premorbid lifestyle practices and neuropsychiatric diagnoses years before diagnosis. This suggests a long premotor phase and highlights opportunities for earlier diagnosis and further mechanistic investigation. The inverse association with cancer mirrors the relationship seen in other neurodegenerative conditions and may point toward shared mechanisms. © 2026 International Parkinson and Movement Disorder Society.
Objective::Patients with chronic pancreatitis commonly experience abdominal pain, anxiety, depression, reduced mobility, and difficulty performing daily activities or maintaining employment. These factors contribute to diminished quality-of-life and high healthcare utilization. This study aims to explore the relationship between specific quality-of-life domains among patients with chronic pancreatitis.Methods::A 55-item online survey was administered to patients with the diagnosis of chronic pancreatitis at 3 Mayo Clinic sites from December 26, 2023, to December 26, 2024. The survey included validated questions assessing demographic, clinical, and quality-of-life metrics using EuroQol 5-Dimension 5-Level instrument—a standardized assessment tool that evaluates 5 key health dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression.Results::Of the 298 patients with chronic pancreatitis who completed the survey, employed patients had decreased odds of reporting problems with mobility (odds ratio [OR] = 0.45, P < .05), self-care (OR = 0.26, P < .01), usual activities (OR = 0.47, P <.05), and anxiety/depression (OR = 0.41, P < .05). Similarly, older patients had decreased odds of reporting problems with self-care (OR = 0.91, P < .01), usual activities (OR = 0.96, P < .01), pain/discomfort (OR = 0.96, P < .01) and anxiety/depression (OR= 0.92, P < .01). However, Medicare patients had greater odds of reporting problems with self-care (OR = 5.54, P < .01) and pain/discomfort (OR = 2.58, P < .05). Conclusions::Chronic pancreatitis impacts multiple dimensions of quality-of-life beyond pain. The EuroQol 5-Dimension 5-Level tool enables comprehensive assessment of physical and mental health. Our findings highlight key associations between patient characteristics and quality-of-life domains, supporting the need for individualized, deficit-targeted interventions. These results also suggest a potential role for vocational rehabilitation in promoting functional recovery and enhancing overall well-being in individuals with chronic pancreatitis.
As patients live longer with cancer, traditional treatment models centered around hospitals and infusion centers increasingly burden patients, caregivers, and health care systems alike. These burdens are logistical, financial, and emotional, and they are especially profound for older adults and individuals in rural or underserved areas, who face added challenges in accessing centralized care. To address these growing inequities and systemic pressures, Mayo Clinic piloted an innovative model of home-based chemotherapy through its Cancer CARE (Connected Access and Remote Expertise) Beyond Walls program - CCBW. This program reimagines oncology care by integrating virtual oversight, remote patient monitoring (RPM), mobile health services, and a unified software platform connected to the electronic medical record. From April 1, 2023, to August 31, 2023, the CCBW pilot enrolled 10 patients who, collectively, received 93 intravenous chemotherapy infusions at home. Clinical safety was closely monitored through a virtual command center, with RPM data and mobile care teams enabling timely intervention when needed. Across the pilot, there were no infusion reactions or catheter-related infections, and the minor complications, including two cases of hypokalemia and two unrelated falls, were successfully managed within the home setting, avoiding emergency department visits or hospitalization. Feedback from seven patients underscored the acceptability and advantages of this home-based approach. From the original 10 pilot participants, 8 patients received surveys, of whom 7 responded. One respondent skipped select survey items. Among respondents, six of six reported feeling comfortable remotely interacting with the care team by phone or tablet, and seven of seven reported feeling emotionally supported by the care team. These early findings suggest that delivering chemotherapy in the home is not only clinically feasible and safe, but that it is also valued by patients. The CCBW model holds promise for reshaping oncology care delivery by leveraging digital health tools and decentralized service models to meet patients where they are. With a larger randomized trial launched in August 2023, just after this pilot implementation study, further evaluation will help determine the model's scalability, cost-effectiveness, and long-term outcomes. If successful, this approach could serve as a scalable blueprint for expanding access to cancer treatment across diverse populations and geographies, while supporting broader shifts in U.S. health care policy toward more patient-centered, home-based care.
Introduction: Social distancing and wearing a face mask are highly recommended to mitigate the transmission of coronavirus disease 2019 (COVID-19). However, the success of these strategies relies on individuals’ adherence and public compliance. This study was conducted to assess the level of belief in social distancing and face mask practices in communities in low- and middle-income countries (LMICs) and to identify their possible determinants. Methods: A cross-sectional study was conducted in ten LMICs countries in Asia, Africa, and South America from February to May 2021. A questionnaire was used to assess the belief, practice, and their plausible determinants. Identification of the associated determinants was performed using a logistic regression model. Results: Our data revealed that only 62.6% and 66.9% of the participants had good beliefs in social distancing and good face mask practices, respectively. Residing in the Americas, having a healthcare-related job, knowing people in immediate social environment who are or have been infected and exposure to information of COVID-19 cases on social media or TV were factors significantly associated with good belief in social distancing. Residing country, gender, monthly household income, type of job and exposure to information of COVID-19 cases were significantly associated with face mask wearing practice. Conclusion: The proportion of participants having good beliefs in social distancing and good face mask practices is relatively low (<75%). Hence, sustained health campaigns regarding social distancing benefits and face mask-wearing practices during COVID-19 are critical in LMICs.
Background: Specialised knowledge in adult congenital heart disease is crucial but often lacking, particularly in resource-limited settings. The Global Conversations in Adult Congenital Heart Disease webinar series was initiated to provide accessible, global education via virtual platforms.Objective: This study evaluates the attendance patterns, participant demographics, knowledge outcomes, and audience feedback of the Global Conversations in Adult Congenital Heart Disease webinar series, analysing 19 monthly sessions conducted from October 2023 to April 2025.Methods: Registration data, session viewership, and total series reach were recorded. Demographics were collected per session. Pre- and post-session quizzes were used to assess changes in knowledge; scores from these independent groups were compared using the Mann-Whitney U test. Post-webinar surveys collected improvement suggestions.Results: Out of 1,956 registrants from 89 countries, 54.6% attended the sessions, representing 1,068 participants from 64 nations: mainly Colombia (30.9%), Peru (18%), the USA (14.1%), and Mexico (9.9%). Median quiz scores improved from 50% pre-session (n = 120) to 100% post-session (n = 108), a statistically significant gain (p = 0.035). Notably, 29% had no prior adult congenital heart disease education. Most post-webinar survey respondents rated case presentations and discussions as excellent (75.0%) or good (20.1%). Qualitative feedback suggested areas for improvement included audiovisual quality, audience engagement, content delivery, and language accessibility.Conclusion: The Global Conversations in Adult Congenital Heart Disease webinar series successfully engaged a diverse international audience and showed significant differences in quiz scores between pre- and post-session independent groups, demonstrating the potential benefit and feasibility of virtual education in bridging gaps in adult congenital heart disease training, particularly in resource-limited countries.
