Sufcient evidence from large-scale epidemiological studies indicates that environmental noise adversely affects human health and well-being.1 The social costs of trafc noise are signicant. The World Health Organization (WHO) has estimated the burden of trafc-related disease in the European Union (EU) as a loss of 1.6 million disability-adjusted life years (DALYs) per year. This translates into a per capita loss of one to two days per year, and it is claimed that only air pollution imposes a larger disease burden.
Lacunar infarcts and vascular dementia are important phenotypic characteristics of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, the most common inherited cerebral small vessel disease. Individuals with the disease show variability in the nature and onset of symptoms and rates of progression, which are only partially explained by differences in pathogenic mutations in the NOTCH3 gene. Recognizing the disease early in its course and securing a molecular diagnosis are important clinical goals, despite the lack of proven disease-modifying treatments. The purposes of this scientific statement are to review the clinical, genetic, and imaging aspects of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, contrasting it with other inherited small vessel diseases, and to provide key prevention, management, and therapeutic considerations with the intent of reducing practice variability and encouraging production of high-quality evidence to support future treatment recommendations.
Originally hosted on http://www.mwdeem.rice.edu/files/ and http://www.hypotheticalzeolites.net/DATABASE/DEEM/index.php but as of September 2020, none of these websites are reachable. These are the two databases, exactly as downloaded on 14 September 2013, from http://www.mwdeem.rice.edu/files/ They are "DEEM DATABASE latest version - uploaded 2011-01-21", as labeled on http://www.hypotheticalzeolites.net/DATABASE/DEEM/index.php The structures were made freely available by Michael Deem and co-workers for many years, and for the sake of research reproducibility and open science, I am hosting them here as a mirror of the lost websites.
EDITOR'S NOTE: This article is Part 3 of a 3-Part series. The FCA is a statute that imposes liability on parties for certain acts of knowingly submitting false claims for reimbursement to the government. [1] The FCA applies not only to health fraud law issues, but also to any other false claim submitted to the U.S. government. [2] The law was first passed into law in 1863. [3] It was passed over concern of civil war troop suppliers submitting false claims to the Union Army. [4] The law has been amended multiple times throughout history, in major part to bring the penalties in line with the current value of the dollar. [5] [1] False Claims Act , 31 U.S.C. §§ 3729–3733 (West 2010). [2] David S. Mitchell, Jr., An Introduction to the False Claims Act , Ark. Law., Summer 2016, at 26 (2016). [3] The False Claims Act: A Primer , U.S. Department of Justice (Apr. 22, 2011), https://www.justice.gov/sites/default/files/civil/legacy/2011/04/22/C-FRAUDS_FCA_Primer.pdf. [4] The False Claims Act: A Primer , U.S. Department of Justice (Apr. 22, 2011), https://www.justice.gov/sites/default/files/civil/legacy/2011/04/22/C-FRAUDS_FCA_Primer.pdf. [5] The False Claims Act: A Primer , U.S. Department of Justice (Apr. 22, 2011), https://www.justice.gov/sites/default/files/civil/legacy/2011/04/22/C-FRAUDS_FCA_Primer.pdf.
