Oslo University Hospital, Aker (also known as Aker Hospital or just Aker) is one of the four main campuses of Oslo University Hospital. It was an independent hospital from 1895 to 2009, under the name Aker Hospital and from 2002 Aker University Hospital. Originally established as the municipal hospital of Aker, the hospital became a university hospital affiliated with the University of Oslo in 1948..
Abstract Hip preservation surgery is increasing both in Norway and internationally. Despite growing interest in the field, there remains considerable variation regarding surgical indications, techniques and implant choices across institutions. To address this and to improve understanding of clinical practice and outcomes, hip preservation procedures in adolescents and young adults were incorporated into the Norwegian Paediatric Hip Register in 2013. This study highlights the development of the registry and reports baseline demographics, perioperative details and patient-reported outcomes, including iHOT-12. Data from 900 patients with 1013 procedures are presented, which includes 273 open and 740 arthroscopic surgeries. The average age was 25.9 years for the open group and 31.9 years for the arthroscopic group. Periacetabular osteotomy (79%) was the most common open procedure, while isolated cam resection accounted for 40% of the arthroscopic procedures. Mean iHOT-12 improved significantly one year postoperatively from 44.1 to 63.7 (P <.001) after open surgery and from 45.3 to 64.1 (P <.001) after arthroscopy. The implementation of the hip preservation registry enables systematic national evaluation of this field and may help to enhance knowledge and decision-making in hip preservation surgery.
Exposure to parental suicide or substance-related death can be a risk factor for unwanted developmental trajectories. The stigma and taboo that often follow a death subject to being morally sanctioned in society ('special deaths') pose an extra challenge for the surviving child and family. The support of informal and formal networks is an important factor in adaptive coping; however, when the death is not socially recognised, the child's access to support can be limited. This article presents the results of a systematic literature review seeking to explore children's access to support when parentally bereaved as the result of suicide or a substance-related death. All six studies included address access to support after a suicide-related death. All studies focus on how children can be supported by loss-oriented activities, particularly how to facilitate open communication between the child and their surroundings. Based on this review, the authors recommend developing research on: 1) support for child survivors in the aftermath of substance-related death, 2), children's everyday grieving practices, including their access to support for restoration-oriented activities, 3) the effects of social support on mental health outcomes, and 4) to developing research designs that allow for disturbing the phenomena of stigma production.
Abstract Background Cardiovascular disease is a major cause of mortality and morbidity worldwide, and primary prevention efforts are poorly developed in people at high cardiovascular risk. On this background, we performed the Hjerteløftet Study and demonstrated that participation over 36 months in a multimodal primary prevention programme, significantly reduced validated cardiovascular risk scores. In the current substudy we aimed to further explore several elements and effects following the intervention programme. Methods A random sample from the original Hjerteløftet Study was included for further examinations (n = 255, 40% women), and these patients were already randomized to an intervention group (IG) (n = 127), or a control group (CG) (n = 128). We compared changes from baseline to 36-months follow-up in physical activity, cardiorespiratory fitness, psychological well-being (WHO-5), cardiovascular medication use, smoking habits, and cardiometabolic risk factors (blood pressure, lipids, blood glucose, HbA1c, Apolipoprotein A-I, Apolipoprotein B and high-sensitive C-reactive protein). Results Self-reported physical activity increased significantly with absolute difference in mean delta Physical Activity Index score in the IG compared to the CG: 0.90, 95% CI: 0.10 to 1.70, p = 0.028 (ANCOVA). There were no corresponding differences in cardiorespiratory fitness. The participation resulted in psychological well-being improvement in both groups with a larger increase in the IG compared to the CG. The mean difference in delta WHO-5 score was 5.06, 95% CI: 0.68 to 9.45, p = 0.024, and 3.28, 95% CI: -0.69 to 5.25, p = 0.104 when controlled for baseline values (ANCOVA). The use of antihypertensive medication increased significantly more in the CG (p = 0.044). Only minor, nonsignificant changes were observed for traditional risk factors and cardiometabolic variables. Conclusions Participation in the Hjerteløftet Study intervention programme resulted in an improved physical activity level, but without changing cardiorespiratory fitness. Participation in the programme also tended to improve psychological well-being, possibly related to increased physical activity, less smoking and less use of cardiovascular medication. Concerning the metabolic status, no major differences were observed, but minor changes may have been concealed by a larger increase in cardiovascular medication use in the control group. Trial registration ClinicalTrials.gov (NCT01741428), 04/12/2012.
Abstract Background and Hypothesis Around 5%–7% of the adult population are estimated to have lifetime psychotic experiences (PEs), which are associated with psychosis risk. PEs assessed with Community Assessment of Psychic Experiences (CAPE) are associated with psychosis but also non-psychotic disorders, which could be partly explained by CAPE indirectly capturing emotional symptoms. We investigated the psychometric properties of a shorter version, CAPE-9, and whether CAPE-9 scores are associated with lifetime psychotic or non-psychotic mental disorders after controlling for current anxiety and depressive symptoms. Design CAPE-9 questionnaire data were obtained from 29 021 men (42.4 ± 5.6 yrs.) from the Norwegian Mother, Father, and Child Cohort Study. We investigated CAPE-9 reliability and factor structure. Logistic regression was used to test effects of current anxiety and depressive symptoms (SCL-12) on associations between CAPE-9 scores and psychiatric diagnoses. Results CAPE-9 fit a previously reported 3-factor structure and showed good reliability. Twenty-six percent reported at least one lifetime PE. CAPE-9 scores were significantly associated with most psychiatric disorders (schizophrenia, depression, bipolar disorder, substance abuse, anxiety, trauma-related disorders, and ADHD). After controlling for concurrent emotional symptoms, only associations with schizophrenia (OR = 1.29; 95% CI = 1.18–1.38) and trauma-related disorders (OR = 1.09; CI = 1.02–1.15) remained significant. Conclusions CAPE-9 showed good psychometric properties in this large population-based adult male sample, and PEs were more clearly associated with psychotic disorders after controlling for current emotional symptoms. These results support the use of the short CAPE-9 as a cost-effective tool for informing public health initiatives and advancing our understanding of the dimensionality of psychosis.
Objective Randomized trials testing the effect of antibiotics for chronic low back pain (LBP) with vertebral bone marrow changes on MRI (Modic changes) report inconsistent results. A proposed explanation is subgroups with low grade discitis where antibiotics are effective, but there is currently no method to identify such subgroups. The objective of the present study was to evaluate whether distinct patterns of serum cytokine levels predict any treatment effect of oral amoxicillin at one-year follow-up in patients with chronic low back pain and Modic changes at the level of a previous lumbar disc herniation. Design We used data from an overpowered, randomized, placebo-controlled trial (the AIM study) that tested 100 days of oral 750 mg amoxicillin vs placebo three times daily in hospital outpatients with chronic (>6 months) LBP with pain intensity ≥5 on a 0–10 numerical rating scale and Modic changes type 1 (oedema type) or 2 (fatty type). We measured serum levels of 40 inflammatory cytokines at baseline and analysed six predefined potential predictors of treatment effect based on cytokine patterns in 78 randomized patients; three analyses with recursive partitioning, one based on cluster analysis and two based on principal component analyses. The primary outcome was the Roland–Morris Disability Questionnaire score at one-year follow-up in the intention to treat population. The methodology and overall results of the AIM study were published previously. Results The 78 patients were 25–62 years old and 47 (60%) were women. None of the three recursive partitioning analyses resulted in any suggested subgroups. Of all main analyses, the largest effect estimate (mean difference between antibiotic and placebo groups) was seen in a subgroup not predefined as of main interest (Cluster category 3+4; −2.0, 95% CI: −5.2–1.3, RMDQ points; p-value for interaction 0.54). Conclusion Patterns of inflammatory serum cytokine levels did not predict treatment effect of amoxicillin in patients with chronic LBP and Modic changes. Clinical Trial Registration Number ClinicalTrials.gov (identifier: NCT02323412).
