Pachhunga University College (PUC) is a public institute in Aizawl, Mizoram, and the only constituent college of Mizoram University, a central university established by an Act of Parliament of India. Founded in 1958 as Aijal College, it is the oldest and largest college in Mizoram, by enrolment and campus size. It started with intermediate of arts (equivalent of higher secondary education) courses, and later expanded to bachelor's degrees in arts, commerce and science. With the opening of master's degree courses in Mizo, philosophy and life sciences, it became the first postgraduate college in Mizoram.The college is named in honour of Pachhunga, a leading businessman and politician, who funded its initial management in 1962. It became university college when the North Eastern Hill University incorporated it as its only constituent college in 1979. The permanent campus, occupied since 1965, is situated in College Veng, a locality at the eastern end of Aizawl. The 138-acre campus is the only verdant forest reserve in Aizawl, and is referred to as the "lung of the city." For its conservation of forests, it received the Indira Priyadarshini Vrikshamitra Awards in 1995, a national award for pioneering and innovative works in afforestation and wasteland management, from the Ministry of Environment, Forest and Climate Change, Government of India.It received the Best College award from the Zoram Research Foundation, consecutively in 2004 and 2006. Between 2009 and 2013, the Department of Science and Technology of India awarded the college with a special scheme of Fund for Improvement of Science and Technology Infrastructure (FIST). In 2011, the Department of Biotechnology of India set up Institutional Biotech Hub, which was upgraded to Advanced Institutional Biotech Hub in 2017. The same year, DBT awarded its Star College Scheme. The National Assessment and Accreditation Council classified it as B grade with a cumulative grade point average of 2.78 in 2011, and raised it to A+ grade with a CGPA of 3.51 in 2016, the highest score in Mizoram. The National Institutional Ranking Framework listed it among the best 150 colleges in India (rank band within 101–150). In 2017, the University Grants Commission made it College with Potential for Excellence.
This study presents the first bulk geochemical analysis of shale samples from the Upper Bhuban Formation near Tuirial in Saitual District, Mizoram, northeast India. The Hydrogen Index (HI) range from 33.33 to 95.65 mg HC/g TOC indicates that the studied shale contains type III-IV kerogen and is derived mainly from ligno-cellulosic organic matter mixed with oxidized plant debris. Low total organic carbon (0.20–0.33 wt
Herein, we have prepared 15-bromobenzo[4,5]quinolino[3,2,1-kl]phenothiazine (BQPTZ) and characterized it using 1H NMR, 13C NMR and HRMS techniques. Furthermore, the compound was crystallized using a DCMhexane mixture. Single-crystal X-ray diffraction analysis revealed that the material crystallizes in an orthorhombic system with Pbca space group symmetry. This crystal structure is stabilized by weak interactions such as C-H & sdot;& sdot;& sdot;it and it & sdot;& sdot;& sdot;it stacking interactions. These interactions have also been confirmed by Hirshfeld surface analysis, with the fingerprint plots revealing that [H & sdot;& sdot;& sdot;H (38.3 %) and C & sdot;& sdot;& sdot;H (22.5 %)] atoms account for the majority of intermolecular interactions compared to other atoms. To explore the compound's electronic properties, we used a generalized gradient approximation (GGA) to the exchange-correlation functional of density functional theory (DFT). The partial density of states (PDOS) was calculated to identify the electronic states of each atom in the valence and conduction regions. After analyzing the band structure and considering the probability of interband transitions of the electrons, we estimated the optical properties, such as the dielectric constant (8(w)), absorption coefficient (alpha), refractive index (ti), and optical conductivity (sigma). The compound exhibits anisotropic symmetry; hence, the spectra of optical response along the xx, yy, and zz axes are not the same in all directions. The calculated results of BQPTZ are of great significance in the further development of organic compounds that will find extensive applications in optoelectronic devices.
By using first-principles density functional theory (DFT) and the Boltzmann transport equation, we have calculated the corresponding electronic and thermoelectric properties of LiCdSb. For calculating electron transport properties, accurate band-structure estimation is crucial. Hence, for the precise band gap calculation, we have implemented a hybrid functional HSE06, which is widely known for its high accuracy. To evaluate the thermoelectric performance of a material, the calculation of lattice thermal conductivity (Kl) is a key parameter. However, from a theoretical perspective, the calculation of lattice thermal conductivity is very complex and demands huge computational resources. Therefore, in this work, we have opted for an alternative method of machine-learning interatomic potentials (MLIPs) for the calculation of Kl. Our result of Kl=0.24 Wm^-1K^-1 at room temperature is in qualitative agreement with the available theoretical and experimental data. The figure of merit (ZT) with Kl estimated from Slack+TDEC ZT is 0.18 at 300 K, and machine learning (ML) models ZT is 0.17 at 300K, combining with HSE06-based electronic transport properties agreed well with the available experimentally reported value of ZT is 0.10 at 300K. However, we report the ZT value well above the benchmark value of 1 beyond 600K. The ZT value exceeding 1 at higher temperatures makes LiCdSb a promising material for high-temperature energy conversion.
This study explores conjugate connections on Riemannian manifolds, with a focus on the quarter-symmetric recurrent metric connection. We introduce and analyze conjugate quarter-symmetric recurrent metric connection and explore its geometric properties including torsion tensor, metric compatibility, curvature behavior and conditions for Ricci solitons. Furthermore, we investigate semi-conjugate and generalized conjugate quarter-symmetric recurrent metric connection and study its detailed overview of characteristics and implications properties. The work also presents new results on the characterization of Ricci solitons in various settings such as W_i -flat and concircular flat manifolds and identifies conditions under which the manifold becomes quasi-Einstein or hyper-generalized quasi-Einstein. These findings generalize and unify several earlier results on symmetric and non-symmetric connections.
Background and Aim:The increasing prevalence of drug-resistant fungal, malarial, and helminth infections necessitates the identification of novel, broad-spectrum therapeutic agents. Alstonia scholaris, widely used in Mizo traditional medicine, has been reported for treating microbial and parasitic infections. This study aimed to evaluate the multifaceted anti-infective efficacy of a geographically distinct Mizoram chemotype of A. scholaris through in vitro assays and molecular docking analyses. Materials and Methods:Methanolic bark extract of A. scholaris was assessed for antifungal activity against Aspergillus fumigatus, Candida albicans, and Neocosmospora keratoplastica using the agar poison technique. Antimalarial activity was tested against chloroquine-sensitive (3D7) and multidrug-resistant (K1) strains of Plasmodium falciparum using a SYBR Green I-based fluorescence assay. Cytotoxicity was evaluated in Vero C1008 cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Anthelmintic efficacy was determined against Raillietina echinobothrida using histological and scanning electron microscopy analyses. Bioactive compounds were identified by gas chromatography-mass spectrometry (GC-MS), followed by molecular docking against key pathogen targets. Results:The extract demonstrated significant antifungal activity, with N. keratoplastica being the most susceptible species. Antimalarial activity showed comparable efficacy against both P. falciparum strains, with IC50 values of 43.40 µg/mL (3D7) and 45.60 µg/mL (K1), and a low resistance index of 1.05. Cytotoxicity analysis indicated high CC50 (>100 µg/mL), suggesting safety, although selectivity indices were moderate. Anthelmintic activity revealed concentration-dependent effects, comparable to albendazole (p > 0.05). Histological and ultrastructural analyses confirmed severe tegumental and internal tissue damage in parasites. GC-MS identified triterpenoids, predominantly α-amyrin and kolavenol. Docking studies revealed strong binding affinities of α-amyrin with fungal sterol 14α-demethylase (CYP51, at -10.4 kcal/mol), malarial S-adenosyl-L-homocysteine hydrolase (SAHH, at -10.0 kcal/mol), and helminth glutamate-gated chloride channel (GluCl, at -9.4 kcal/mol), supporting multi-target activity. Conclusion:The Mizoram chemotype of A. scholaris exhibits broad-spectrum anti-infective potential with antifungal, antimalarial, and anthelmintic activities. The predominance of triterpenoids, particularly α-amyrin and kolavenol, distinguishes it from other chemotypes and underpins its pharmacological profile. These findings validate its traditional use and highlight its potential as a source of novel anti-infective agents, warranting further in vivo and mechanistic studies.
