The New QEII Hospital is located in Welwyn Garden City and managed by East and North Hertfordshire NHS Trust..
The emergence of Plasmodium knowlesi as the predominant cause of malaria in Malaysian Borneo raises important questions about protective genetic factors in endemic populations. This study investigates two common erythrocyte polymorphisms, glucose-6-phosphate dehydrogenase (G6PD) deficiency and Filipino β-thalassemia, for association with P. knowlesi infection risk. A retrospective case–control study compared 106 PCR-confirmed P. knowlesi cases with 89 controls from Sabah, Malaysia. Genotyping used multiplex PCR (8 major Southeast Asian G6PD variants) and gap-PCR (Filipino β-thalassemia deletions). Statistical analysis employed Fisher’s exact tests and logistic regression models to evaluate associations with infection risk, including controlling for age, sex, ethnicity and district site. G6PD deficiency genetic variants were present in 4/106 (3.8
BACKGROUND:Peripheral intravenous catheters (PIVCs) are essential in the emergency department (ED). Randomised control trials (RCTs) have examined various techniques and technologies to optimise effective PIVC insertion, and care in the ED, but these data have not been synthesised to allow application in clinical care. AIMS:To systematically review and synthesise the findings of published RCTs on the effectiveness of techniques and technologies to improve insertion success and reduce overall PIVC failure in the ED. METHODS:Full text journal articles in English and Chinese that study PIVC insertion or outcome techniques or technologies in ED settings will be extracted from 6 electronic databases. Results will be summarised following meta-analysis. CONCLUSION:This review will identify techniques and technologies that improve PIVC insertion success and function in the ED. By analysing pooled outcomes, the researchers aim to provide recommendations to enhance PIVC insertion success, and ultimately patient outcomes. Identifying effective methods will also highlight key areas for future research.
Implant based reconstruction had been used for centuries and was popularised by western country since 1964. Being a developing country, this oncoplastic technique is slowly gained trust and accepted by our people. In North Borneo Malaysia especially where the people generally are more conservative when it comes to breast cancer treatment, it takes longer time for this technique to be chosen and accepted by them. This paper aim to highlight our early experienced as the only breast and endocrine unit for whole North Borneo, Malaysia, with implant-based breast reconstruction following mastectomy in our breast cancer patient. Data was retrospectively analysed from 2017 till 2023. Total of 35 patients were enrolled in this study. Each of them was given BREAST Q questionnaire during follow up to assess patient satisfaction. Thirty patients were enrolled in this study. Mean age of patient was 40-year-old with most of them had early breast cancer. 46% (n=14) had received radiotherapy. Small percentage of the patient developed surgical site infection after reconstruction that required longer antibiotics and one of them needs re-operation for open drainage. In assessment of quality of life, more than 70% of patient give score of 75-100 for satisfaction with implant, psychosocial and physical well-being. However, in patient who received radiotherapy, the mean scores were much lower compared to those who did not received radiotherapy. Implant-based reconstruction had low complications and give high satisfaction with surgical outcome among patient in North Borneo Malaysia.
