Trans and gender diverse (hereafter trans) youth are likely to experience poor mental health and report elevated rates of depression, anxiety, and suicidality. This is driven by gender minority stress and exposure to stigma and discrimination in society. This feasibility study aimed to evaluate the feasibility and acceptability of a group cognitive behavioral therapy intervention targeting gender minority stress in trans young people (Trans Adolescent Group ThErapy for Alleviating Minority stress [TAG TEAM]), which was codesigned with trans youth. Participants were trans young people (N = 28) who were waiting to access gender-affirming care at a pediatric gender service in Victoria, Australia (M-age = 15.1, SD = 0.8; trans male = 53.9%; Anglo-Celtic = 53.9%). Participants attended online or in-person intervention arms and completed assessments at baseline and postintervention. The study was conducted from October 2023 to August 2024. The TAG TEAM intervention and study design were found to be feasible and acceptable, with modifications to the recruitment strategy, intervention, and outcome measures indicated. Although both delivery modes were feasible and acceptable, online delivery was considered more feasible and acceptable than in-person delivery. The results of this feasibility study will inform a future consumer-led randomized controlled trial of the TAG TEAM intervention, which will be conducted in partnership with trans young people. Australian New Zealand Clinical Trials Registry: ACTRN12623000302651.
OBJECTIVES:To compare the measurement properties of paediatric patient-reported outcome measures (P-PROMs) used in clinical trials and practice for common conditions. DESIGN:Data from the Australian Paediatric Multi-Instrument Comparison study were used, including children aged 5-18 years with autism spectrum disorder (ASD) (n=510), asthma (n=487), eating disorder(s) (n=216), epilepsy (n=298), recurrent abdominal pain (n=392), sleep problems (n=346), dental problems (n=490), type 1 diabetes (T1D) (n=67), enuresis (n=182) and no health conditions (reference group) (n=1259). The acceptability, response distribution (floor/ceiling effects), known-groups validity, test-retest reliability, responsiveness and convergent validity of the Paediatric Quality of Life Inventory (PedsQL), EuroQol Group's Youth instruments with three and five response options (EQ-5D-Y-3L and EQ-5D-Y-5L), Child Health Utility 9D (CHU9D), Assessment of Quality of Life 6D (AQoL-6D), Health Utilities Index Mark 3 and Patient-Reported Outcomes Measurement Information System Paediatric Profile 25 (PROMIS-25) were assessed. RESULTS:PedsQL, EQ-5D-Y-3L, EQ-5D-Y-5L, CHU9D and PROMIS-25 were easy and quick to complete, indicating acceptability. Only the EQ-5D-Y-3L and EQ-5D-Y-5L demonstrated ceiling effect issues. All measures were able to differentiate between children with no health conditions and children with each condition (p<0.001, effect sizes between 0.47 and 3.5), indicating known-groups validity. Test-retest reliability varied by condition; however, the PedsQL and EQ-5D-Y-5L were the most reliable. CONCLUSIONS:Certain P-PROMs may be preferred in different conditions, that is, ASD (PedsQL and EQ-5D-Y-5L), asthma (PedsQL), eating disorder(s) (PedsQL and CHU9D), epilepsy (PedsQL and CHU9D), recurrent abdominal pain (PedsQL, EQ-5D-Y-5L and CHU9D), sleep problems (PedsQL), dental problems (PedsQL), T1D (PedsQL and CHU9D) and enuresis (PedsQL). Notably, the PedsQL performed favourably in all conditions assessed. More evidence is required on the responsiveness of P-PROMs to changes in child health. TRIAL REGISTRATION NUMBER:ACTRN12621000657820.
The use of standardised structured radiology reports improves the consistency, reproducibility and overall quality of radiological reporting while enhancing communication with referring physicians and ultimately contributing to improved patient care. To develop a standardised structured report template for foetal and neonatal postmortem magnetic resonance imaging through expert consensus. A Delphi survey was conducted between September and December 2025 among members of the ESPR Postmortem Task Force and other recommended international PM imaging experts. The surveyed items were derived from clinically used MRI reporting templates across the expert group. Consensus was defined using a ≥75
Tropical Cyclones (TCs) pose significant and evolving threats to Pacific Island Countries and Territories (PICTs) healthcare systems. Changes in cyclone intensity, frequency, and spatial distribution due to anthropogenic climate change are likely to increase these threats. Accessible information on future uncertainty of high intensity TCs can enable adaptation that reduces the severity of systemic disruptions. However, the infrequency of high-intensity TC events in historical and GCM data and the small and dispersed geometries of PICTs make modeling the statistics of TC impacts challenging. In this paper, we try to close this gap by developing EMPIRIC_TC, a deep-learning emulator of a statistical-dynamical TC model, to provide local, accessible, ensemble projections of high-intensity TCs in the South Pacific. We implement EMPIRIC_TC using a Fourier Neural Operator and show that it outperforms a UNet and Nearest Neighbors regression model at predicting facility relevant TC hazard and reproducing ensemble means. We then explore fundamental limits to the predictability of infrequent extreme events from climatic conditions and show their affect on deep learning model performance. The emulator allows for high-skill, adaptable, and near-instantaneous projections of TC hazards, estimation of climate model and internal variability-related uncertainty, and evaluating projection uncertainty. The emulation system, EMPIRIC_TC, is available through a web portal for the use of PICT collaborators.
Vasopressin is commonly used as an adjunct vasoactive infusion in paediatric intensive care. We aimed to describe changes in urine output, after vasopressin initiation, in children admitted to a paediatric intensive care unit (PICU). We performed a retrospective cohort study of patients aged < 18 years who received a vasopressin infusion between 2017 and 2023. Urine output in the 6 h prior to vasopressin commencement was compared with four subsequent 6-hour epochs over the following 24 h. Average percentage change in urine output was estimated using linear regression on the log scale, accounting for repeated measures with generalised estimating equations. Prespecified subgroup analyses were conducted in children with acute kidney injury (AKI), and contemporaneous changes in serum sodium were described. Among 247 children who received vasopressin, the most common diagnostic groups were congenital heart disease 131(53
