Safdarjung Hospital is a multi-specialty hospital, and the largest central government hospital in India if measured by bed strength. It is associated with Vardhman Mahavir Medical College and located in the heart of New Delhi on the Ring Road, opposite to the All India Institute of Medical Sciences (AIIMS). Until the inception of All India Institute of Medical Science in 1956, Safdarjung Hospital was the only tertiary care hospital in Delhi. In 1962, it became a centre of training and teaching for post-graduate students of the University of Delhi. From 1973 to 1990, the hospital and its faculty was associated with University College of Medical Sciences. But with the establishment of Indraprastha University in 1998, the hospital was later merged with the Vardhman Mahavir Medical College..
Photobiomodulation therapy (PBMT) using near-infrared (NIR) light offers a non-invasive healing approach with deep-tissue penetration that enhances cellular proliferation, mitochondrial bioenergetics, reduces inflammation, and restores functions. However, clinical evidence for NIR-PBMT in burn care remains limited. This randomized, active-controlled trial evaluated the effects of 904 nm superpulsed laser NIR-PBMT as an adjunct to standard care (SOC; 1% silver-sulfadiazine, paraffin-gauze) for second-degree burn patients. Participants received either sham-exposed (n = 12) or 904 nm-PBMT (n = 12; 100 Hz frequency, 200-ns pulse width, 10 min, 1.1 J/session, twice weekly). The study evaluated re-epithelialization time, wound reduction, pain intensity (VAS score), blood PCT/CRP levels, and microbial load. NIR-PBMT significantly (p < 0.05) accelerated healing, re-epithelialization (8.3 vs. 12.6 days), wound reduction, granulation tissue formation, and decreased pain compared to sham-exposed. Neither group showed evidence of microbial infection or changes in PCT/CRP levels. These findings indicate that NIR-PBMT is an effective non-invasive adjunct therapy for faster repair of second-degree burns. Further, large-scale trials are needed.
Background: Rome IV criteria for the diagnosis of irritable bowel syndrome have been introduced recently hence, there are very few studies conducted to know the prevalence of IBS using these criteria. Prevalence of psychiatric disorder vary depending on criteria used. In view of these facts, this study was conducted to estimate prevalence of psychiatric disorders in patients of IBS fulfilling Rome IV criteria. Material and Methods: Observational study at a tertiary care hospital in northern India. We included 100 patients aged ≥18 years who were diagnosed as irritable bowel syndrome fulfilling ROME IV criteria and assessed for different psychiatric manifestations using Patient health questionnaire after taking informed written consent. Results: 75% of the IBS patient had more than one psychiatric comorbidity, while 25% had no psychiatric illness. The most common psychiatric comorbidity observed was generalized anxiety disorder 44%, followed by major depression in 38%, somatization disorder in 23%, panic disorder 18%, alcohol use disorder 18% and eating disorder. Statistically significant difference was found among patient having somatization disorder, eating disorder and alcohol use disorder among male and female. Conclusion: The study emphasizes the need for regular counselling regarding psychiatric associations in IBS patients.
Introduction and importance: Adenosquamous carcinoma (ASC) of the colon is a rare malignancy, representing approximately 0.06 % of colorectal cancers (CRC). It is characterized by the coexistence of adenocarcinoma and squamous cell carcinoma components. Case presentation: Here, we present a unique case of a 47-year-old male diagnosed with collision-type ASC, featuring both signet-ring adenocarcinoma and squamous cell carcinoma. The patient presented with abdominal pain and distension, and imaging revealed multiple colonic strictures and lymphadenopathy. Surgical intervention included an extended left hemicolectomy. Histopathology confirmed the presence of two distinct tumor components, with no evidence of lymph node metastasis. Immunohistochemistry was positive for p63 in the squamous cell component, while HPV DNA testing was negative. Clinical discussion: ASC is known for its aggressive clinical course and poor prognosis compared to adenocarcinoma. Although rare, its clinical and histopathological features are important for guiding management. Conclusion: This case represents the first reported instance of a collision-type colon ASC with a signet-ring adenocarcinoma component. The patient is currently undergoing neoadjuvant chemotherapy with the modified FOLFOX6 regimen and responding well. Further research is required to elucidate the molecular mechanisms underlying ASC and improve therapeutic outcomes.
BackgroundThere are logistic problems in obtaining adequate microbiological samples for the diagnosis of pulmonary tuberculosis (PTB) in children, globally. Most studies on ultrasound have evaluated mediastinal nodes in children with tuberculosis (TB), but very few studies are available on lung ultrasound (LUS) appearances in proven PTB.PurposeTo study the LUS appearances in children with microbiologically proven PTB and to assess the inter-observer agreement.Materials and MethodsThirty children with microbiologically proven PTB, were evaluated prospectively on LUS and chest radiograph (CR) in Radiology department of a tertiary care hospital, from November 2019 to November 2021. CR was interpreted by an experienced Radiologist (R2); LUS was conducted by a Radiology resident (R1), who was blinded to CR findings; and findings were recorded. Archived static images/videos of LUS were interpreted by R2 after a month, to avoid bias; and findings were recorded.ResultsComposite LUS finding of either consolidation and subpleural nodule (SUN) was detected in 29/30 (96.7%) children with lower zone predominance (70%). Miliary pattern was observed on LUS in 11/30 (33.3%) children, but their CR was normal. Consolidation was detected on LUS in a significantly higher proportion of children (83.3%) than on CR (43.3%). Inter-observer agreement calculated for detection of consolidation and pleural effusion was k = 0.88, for B lines k = 0.79, confluent B lines k = 0.75, miliary nodules k = 0.70 and SUN k = 0.57.ConclusionWe conclude that in low-resource endemic areas, LUS by virtue of being non -invasive and not using ionizing radiation, can be a useful supplementary tool in the diagnosis of childhood PTB.
