Shaheed Mohtarma Benazir Bhutto Medical College (Urdu: شہید محترمہ بینظیر بھٹو طبی کالج, or SMBBMC) is a medical school in Lyari, Karachi, Pakistan, that opened in March 2011. The Principal of the college is Dr. Anjum Rehman. The college was opened with financial support from the Government of Pakistan.Shaheed Mohtarma Benazir Bhutto Medical College part of Lyari General Postgraduate Medical Centre also known as Lyari General Hospital. It also has Institute of Cardiology and is a teaching hospital. It was formerly affiliated with Dow University of Health Sciences..
Aortic stenosis in older adults often requires valve replacement and transcatheter aortic valve implantation (TAVI) is an option with good outcomes. However, recent hospitalizations due to heart failure (HF) may worsen results. This systematic review and meta-analysis adhering to PRISMA guidelines. We systematically searched PubMed, Cochrane Library and Scopus from database inception until July 2025. Data were analyzed by Review Manager using Risk Ratio (RRs) and 95
Background: Acute ischemic stroke due to middle cerebral artery (MCA) occlusion remains a leading cause of mortality and long-term disability worldwide. Rapid revascularization is critical to improving neurological outcomes, and endovascular thrombectomy has become the standard of care for large vessel occlusions in the anterior circulation. This Systematic Review and Meta-Analysis aims to evaluate functional recovery, mortality, and safety outcomes of catheter-assisted mechanical thrombectomy with stent retrievers and catheter-assisted aspiration thrombectomy using data from randomized controlled trials (RCTs) and cohort studies. Method: This study followed PRISMA guidelines and the Cochrane Handbook for Systematic Reviews. A comprehensive search of PubMed (MEDLINE), Scopus, EMBASE, and Google Scholar was performed up to July 2025. Continuous variables were analyzed using mean difference (MD) or standardized mean difference (SMD), while categorical outcomes were assessed using odds ratios (OR), all with 95% confidence intervals (CIs). Heterogeneity among studies was evaluated using the I2 statistic and the Chi-square test. Result: A total of 04 retrospective cohorts, 03 prospective cohorts, and 01 randomized controlled trial met the inclusion criteria. No significant difference was observed between catheter-assisted aspiration thrombectomy (CAT) and stent retriever thrombectomy (SR) in 90-day functional independence (RR = 1.14, 95% CI =0.93–1.39) or mortality (RR = 0.97, 95% CI = 0.72–1.31). Rates of symptomatic intracranial hemorrhage were comparable, with CAT showing a nonsignificant trend toward lower risk. CAT achieved significantly faster recanalization (MD = –38 min, p = 0.0008) and shorter procedure times (MD = –27 min, p = 0.028), though heterogeneity was present. First-pass effect, NIHSS improvement, onset-to-groin puncture time, and rescue therapy requirements showed no significant differences. Overall, CAT demonstrated procedural efficiency advantages, while both techniques achieved similar clinical outcomes. Conclusion: Catheter-Assisted Aspiration offers an advantage over stent providers in terms of faster recanalization and shorter procedure times, offering procedural efficiency without compromising patient-centered results. Although both procedures are comparably effective in functional recovery, mortality, and safety outcomes, further trials can improve the strength of evidence for precise outcomes in population subgroups.
Background:Chronic kidney disease (CKD) and atrial fibrillation/flutter (AF/AFL) frequently coexist in older adults, sharing common risk factors such as hypertension, diabetes, and coronary artery disease. However, long-term national mortality trends among patients with concurrent CKD and AF/AFL remain poorly defined. The primary research question of this study is to examine how the combined presence of CKD and AF/AFL has influenced mortality rates in older adults in the U.S. over the past 26 years. Methods:We analyzed mortality data from the CDC Wide-Ranging Online Data for Epidemiologic Research database for U.S. adults aged ≥65 years from 1999 to 2024. Deaths listing both CKD (ICD-10 N18.0-N18.9) and AF/AFL (I48) were identified. Age-adjusted mortality rates (AAMRs) per 100 000 population were calculated using the 2000 U.S. standard population and stratified by sex, race/ethnicity, census region, and urban-rural status. Temporal trends were assessed using Joinpoint regression to estimate annual percentage change (APC). Results:A total of 203 662 deaths were attributed to concurrent CKD and AF/AFL. The overall AAMR increased from 4.9 per 100 000 in 1999 to 30.0 per 100 000 in 2024. Mortality rose rapidly from 1999 to 2011 (APC: +12.3%, P = 0.0016), followed by a slower, non-significant increase from 2011 to 2024 (APC: +3.9%, P = 0.0767). Mortality was higher in men and in nonmetropolitan areas. Non-Hispanic White and Black populations showed the greatest increases, while Hispanic and Asian/Pacific Islander groups had the lowest rates. The Midwest and West exhibited the highest regional burdens, with notable state-level variation. Conclusions:Mortality linked to concurrent CKD and AF/AFL has risen sharply, with widening disparities by sex, race, and geography. Integrated, equitable care strategies are urgently needed.
