Shri Shankaracharya Technical Campus (formerly Shri Shankaracharya College of Engineering and Technology (SSCET)) is an Engineering College located at Bhilai, Chhattisgarh, India. It is named after Adi Shankaracharya. Established in 1999, it is affiliated to Chhattisgarh Swami Vivekanand Technical University, Bhilai. It is a Unit of Shri Shankaracharya Group of Institutions.
In this study, nickel ferrite/polypyrrole composites were synthesized through in-situ oxidative polymerization to analyze their applicability as an electrode material for supercapacitors. The structural, morphological, and electrochemical properties of the synthesized material have been thoroughly investigated. The electrochemical characterizations have shown that the N5PY5 (50-50 wt%) composite of nickel ferrite and polypyrrole has a specific capacitance of 503.3 F/g at 2 A/g in 6 M KOH, which is three times higher than pure nickel ferrite. The value of solution resistance and charge transfer resistance is also reduced for the composite in comparison to pure nickel ferrite. The enhanced electrochemical performance of the composite electrode was explained on the basis of the synergistic effect between the polypyrrole and nickel ferrite. Polypyrrole acts as a conductive support, provides additional active sites, and improves redox activity and diffusion in the composite electrode. Theoretical analysis using DFT calculation was also employed to analyze the interaction mechanism between the polypyrrole and nickel ferrite. The high adsorption energy (-2.6 eV) and covalent bonding between oxygen and carbon indicated a strong interaction between the nickel ferrite and pyrrole's dimer. Consequently, the composite electrode shows improved stability (88.6 %) as compared to polypyrrole (38.6 %) after 1000 cycles of charging and discharging.
Graphene quantum dots (GQDs) have emerged as promising nanomaterials in cancer therapy because of their unique physicochemical properties. This review comprehensively analyzes the roles of GQDs in cancer diagnostics and treatment, highlighting their biocompatibility, tunable photoluminescence, and surface functionalization capabilities. GQDs exhibit minimal toxicity, efficient cellular uptake, and favorable biodistribution, making them suitable for targeted drug delivery, photothermal therapy (PTT), and photodynamic therapy (PDT). Their intrinsic fluorescence also enables real-time bioimaging, supporting theranostic applications. This study explores their mechanisms of action, including reactive oxygen species (ROS) generation, heat-induced ablation, and pH-responsive drug release. GQDs have demonstrated efficacy across various cancers, such as breast, lung, brain, liver, and pancreatic cancers, through enhanced drug/gene delivery, biosensing, and image-guided therapy. Despite encouraging preclinical results, challenges related to toxicity profiling, standardization, regulatory frameworks, and scalability remain significant barriers to clinical translation. This review emphasizes the therapeutic versatility of GQDs and underscores the need for further research to overcome translational hurdles and realize their full potential in personalized cancer care.
Density functional theory (DFT) was used to analyze the adsorption mechanism of greenhouse gases (CO2, CH4, NF3, and N2O) on pristine, palladium-doped, and boron/palladium co-doped graphitic carbon nitride. It is shown that gases adsorbed on the pristine graphitic carbon nitride surface exhibit weak interaction, while the doped system shows stronger adsorption for most of the gases. The findings from density of states, projected density of states, change in band gap, and charge transfer analysis demonstrate that the incorporation of palladium and boron-palladium atoms substantially improves the adsorption capacity of the graphitic carbon nitride monolayer for various greenhouse gases, with adsorption energies varying from-0.06 eV to-6.21 eV. Both doped monolayers also have the charge transfer range from-0.01 |e| to-1.27 |e|. Most of the transferred charges are accumulated at the lower unoccupied molecular orbital of greenhouse gases. A higher amount of charge transfer also leads to deformation of the gas geometry. Therefore, the palladium-doped graphitic carbon nitride mono-layer can be regarded as a potential resistive gas sensor for CO2, NF3, and N2O gases, while the high adsorption energy and charge transfer for boron-palladium-doped graphitic carbon nitride make it a potential candidate for a one-time sensor or a scavenger.
The rising volume of healthcare data necessitates a more safe, more scalable, and cost-effective data storage and access solution. This paper describes a preliminary model that combines blockchain with cutting-edge encryption and deduplication to resolve a fundamental problem of outsourcing medical data. The model achieves privacy, auditability, and healthcare regulatory compliance through the use of cryptographic hashing and smart contracts. Moreover, deduplication enhances data retrieval agility. The framework experimentally evaluated increased its scalability, fault tolerance, and energy efficiency. Moreover, the framework improved unauthorized access protections, reduced operating costs 45
This study presents comprehensive preformulation investigations of Ibudilast, a phosphodiesterase inhibitor with therapeutic applications in bronchial asthma, cerebrovascular disorders, multiple sclerosis, and substance use disorders. The research aimed to establish a scientific foundation for rational formulation development by systematically characterizing Ibudilast's physicochemical properties. Organoleptic evaluation confirmed Ibudilast as a white, odorless, bitter, crystalline powder. FT-IR spectroscopy validated the drug's identity through characteristic absorption bands at 3083 cm⁻¹ (aromatic C-H), 2959 cm⁻¹ (aliphatic C-H), 1640 cm⁻¹ (C=O carbonyl), and 1538 cm⁻¹ (aromatic C=C/C=N), confirming the pyrazolopyridine ring structure with isopropyl and isobutyryl substituents. UV spectrophotometry established λmax at 227 nm in methanol. The melting point was determined to be 58-62°C, with slight deviation from literature values (54-58°C), confirming drug purity. Miscibility studies revealed poor water miscibility with complete dissolution in methanol and ethanol within 2-4 minutes. Micromeritic evaluation demonstrated passable flow properties with Carr's Index of 23.19 ± 1.24%, Hausner's Ratio of 1.30 ± 0.04, and angle of repose of 36.45 ± 1.82°. FT-IR compatibility studies with bovine serum albumin demonstrated no chemical incompatibility with only minimal peak shifts (2-4 cm⁻¹), indicating weak physical interactions and confirming BSA's suitability as a carrier for nanoparticle formulation. Optical microscopy revealed irregular crystalline particles with a mean size of 48.35 ± 12.67 μm, suggesting potential benefits from particle size reduction strategies. These comprehensive preformulation data provide essential insights for developing optimized Ibudilast formulations with enhanced bioavailability and therapeutic efficacy.
