Shyam Shah Medical College is among the oldest medical colleges in Madhya Pradesh state of India. It is situated in Rewa city. The college is associated with Sanjay Gandhi Memorial Hospital and Gandhi Memorial Hospital. It is named after Amar Shaheed Shri Shyam Shah Singh, a rebel of the British India Company in the mid-19th century.
Uterine Rupture is one of the most catastrophic events in obstetrics. Poor antenatal care, obstructed labor and previously scarred uterus are the preceding factors. Signs and symptoms are not specified but high rate of suspicion in predisposed patients is key to, decrease the mortality and morbidity. The objective of study was to know the incidence, etiology, choice of surgical management, and outcome in patients of rupture uterus. It is an institution-based retrospective study carried out at the Department of obstetrics and gynecology, Shyam Shah Medical College, Rewa (M.P). All the diagnosed rupture uterus patients admitted from Jan 2016 to Dec 2020 were included in the study. Approval from Institutional ethical committee was taken. Data regarding clinical, investigational, and management details were retrieved from the case records of 80 women with diagnosis of uterine Rupture. Majority of women (92.5
Colorectal cancer (CRC) is an emerging public health challenge in India, with a rising incidence, particularly among younger populations. In addition to conventional clinicopathological staging, molecular biomarkers may provide important insights into tumor biology, prognosis, and therapeutic response. This hospital-based pilot case–control study included 30 histologically confirmed CRC patients treated at Shyam Shah Medical College and Sanjay Gandhi Memorial Hospital, Rewa, during 2023–2024, with paired adjacent normal mucosa serving as controls. mRNA expression of COX-2, CXCL1, and IMP3 was assessed using quantitative real-time PCR, while MTHFR C677T, DPYD rs3918290, and TYMS polymorphisms were analyzed by PCR–RFLP. Associations with clinic-pathological variables and survival outcomes were evaluated using appropriate statistical methods, including Kaplan–Meier analysis. The mean age of patients was 52.7 years, with a male predominance (56.7
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and a leading cause of cardioembolic stroke. In nonvalvular atrial fibrillation (NVAF), thrombus formation occurs predominantly within the left atrial appendage (LAA), making it a key therapeutic target. While oral anticoagulation remains standard for thromboembolic risk reduction, contraindications, elevated bleeding risk, and therapy intolerance drive the need for nonpharmacologic alternatives. This review examines the role of the WATCHMAN left atrial appendage occlusion (LAAO) device in NVAF-related stroke prevention, encompassing pathophysiologic rationale, device design, procedural technique, clinical evidence, post-implantation management, and outstanding evidence gaps. The PROTECT AF and PREVAIL trials established WATCHMAN-based LAAO as noninferior to warfarin for prevention of stroke, systemic embolism, and cardiovascular death, though early procedural complications underscored the importance of operator experience. Subsequent real-world registries confirmed safety and effectiveness in higher-risk, anticoagulation-ineligible populations. Newer-generation platforms including the WATCHMAN FLX and FLX Pro, demonstrate improved sealing performance and procedural safety, while contemporary randomized trials further define LAAO's role relative to DOAC therapy. WATCHMAN-based LAAO represents an important alternative for carefully selected patients, particularly those with high bleeding risk. Optimal patient selection, antithrombotic regimens, and long-term outcomes warrant continued investigation.
Osteomyelitis, a complex bone infection, requires better management strategies to address its chronicity and microbial variations. Therefore, it is of interest to evaluate the demographic, clinical and microbiological characteristics of osteomyelitis cases. A retrospective analysis of 234 patients revealed a strong link between diabetes and chronic osteomyelitis. Staphylococcus aureus was the most common pathogen identified. Histopathological findings showed chronic inflammation and bone necrosis in many cases. Early diagnosis and proper antimicrobial therapy are crucial in preventing chronic outcomes and improving clinical management
