Disorders of gut-brain interaction (DGBI) are common in children and often persist despite conventional treatments, leading families to seek complementary and alternative medicine (CAM). However, evidence for CAM in pediatric DGBI is scarce. This multicenter survey study assessed parents’ and pediatricians’ experiences with and attitudes toward CAM for children with gastrointestinal symptoms. Parents and pediatricians of children (0–18 years) with gastroesophageal reflux disease (GERD) and DGBI (infant colic (IC), functional abdominal pain, and functional constipation) from six Dutch hospitals were included. GERD diagnosis was based on international guidelines, DGBI on Rome IV criteria. Parental surveys addressed child health, medication, (reasons for) CAM use, and attitudes toward CAM research. Pediatricians’ surveys covered experiences and attitudes toward CAM for pediatric DGBI. A total of 677 parents (71
Benign prostatic hyperplasia (BPH) is the main cause of lower urinary tract symptoms (LUTS) in aging men. As the incidence of prostate cancer (PCa) increases with age, coexistence of BPO and PCa is a frequent issue. Radical prostatectomy might be considered as the best option for patients presenting with severe obstructive symptoms, allowing to simultaneously treat both diseases. However, not all patients are eligible or prefer surgery, therefore a large number of patients are referred to receive PCa radiotherapy (RT). Preexisting LUTS represent a well-known risk factor to develop severe genito-urinary (GU) toxicity. While improving urinary function before starting irradiation appears to be crucial, the development of new minimally invasive surgical therapies (MIST) for BPH creates new opportunities for treatment personalization in RT patients with LUTS.
Although early laparoscopic cholecystectomy is the gold standard for acute calculous cholecystitis, its safety in patients presenting more than seven days after symptom onset remains debated. Concerns over increased surgical difficulty and complication rates often results in delaying cholecystectomy, yet evidence supporting this seven-day threshold is lacking. Therefore, this study evaluated the safety of early laparoscopic cholecystectomy in patients operated within versus beyond seven days of symptom onset. This international retrospective cohort included patients who underwent early laparoscopic cholecystectomy for acute calculous cholecystitis at two high-volume centers between 2015 and 2021. Patients were categorized by symptom duration: ≤ 7 days or > 7 days. Multivariable analyses compared major complications (bile duct injury/leakage, bowel injury, bleeding, or postoperative complication Clavien-Dindo grade ≥ 3a), conversions, operative time, and postoperative hospital stay. A total of 1421 patients were included. Of these, 1312 patients (92
The Prostate Cancer Radiological Estimation of Change in Sequential Evaluation (PRECISE) recommendations assess radiological change in serial MRI during active surveillance (AS) for prostate cancer. PRECISE 1–2 indicates radiological regression, PRECISE 3 stability, and PRECISE 4–5 progression. Our aim was to test the PRECISE score as a predictive tool for disease progression in a multicentre international setting. This is a retrospective study in which we collected data from 22 international centres from December 2005 to July 2022, applying two entry criteria: (1) at least two scans (baseline and follow-up); (2) at least two biopsies (baseline and follow-up, the latter after the second scan). Local radiologists reported scans according to PRECISE. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) according to different biopsy thresholds and definitions of progression were calculated. A total of 1667 patients were included. Median follow-up was 4 years (IQR: 2.1–6.3). A total of 1248 (75
Data on the association of previous cardiac surgery (PCS) with outcomes following tricuspid valve transcatheter edge-to-edge repair (T-TEER) are limited. This study aimed to evaluate the impact of PCS on outcomes after T-TEER. This analysis included patients from the EuroTR registry (European Registry of Transcatheter Repair for Tricuspid Regurgitation; NCT0630726) who underwent T-TEER for clinically relevant tricuspid regurgitation (TR) between 2016 and 2024 and had available information on cardiac surgical history. Study endpoints were procedural TR reduction, improvement in NYHA functional class, all-cause mortality, and the composite of death or heart failure hospitalization (HFH) at 2 years. Among 2929 patients, 27.2
