Swami Ramanand Teerth Marathwada University

A hierarchically porous Sb2O3-Bi2O3 (AO-BiO) nano-leaf architecture was synthesized directly onto a nickel-foam via a simple in situ chemical route and explored as a multifunctional electrode for energy storage and water splitting applications. The synergistic coupling between Sb2O3 and Bi2O3, together with abundant oxygen vacancies and an open three-dimensional framework, enables rapid ion/electron transport and enhanced redox activity. As a symmetric supercapacitor electrode, AO-BiO delivers a high specific capacitance of 1738 F g-1 at 5 A g-1, an energy density of 149 Wh kg-1 at a power density of 9540 W kg-1, and 78% specific capacitance retention after 10 000 cycles. In addition, the AO-BiO electrode exhibits excellent bifunctional electrocatalytic activity for overall water splitting, requiring low overpotentials of 248 mV (OER) and 112 mV (HER) at 10 mA cm-2, with stable operation over 40 h. These results demonstrate a clear structure-property-performance relationship and highlight Sb2O3-Bi2O3 nanostructures as promising and durable electrodes for integrated energy storage and hydrogen production benefits.

The complex permittivity spectra for the binary system maltitol‐water, within the frequency spectrum of 10 MHz 30 GHz have to been investigated employing the Time Domain Reflectometry (TDR). An analytical approach was undertaken to determine the static dielectric constant (ε0) and relaxation time (τ) corresponding to various volume fractions of water (Vwater) across various temperature conditions. These dielectric parameters were accurately fitted to the Cole–Davidson model to elucidate the relaxation dynamics. The Refractive Indices, Kirkwood Correlation Factor (KCF), Hydration number (Nhyd) and Thermodynamic parameters (∆H and ∆S) have been calculated thereby elucidating the intermolecular interactions present within the binary mixture. The observed increase in the dielectric constant coupled with a reduction in relaxation time, accompanying with an increase in the water content of the solution, suggests that these properties vary with solute concentration and temperature, shaped by the molecular structure of the solute. The empirically obtained static dielectric constants exhibit a strong correlation with the theoretical values, thereby substantiating the validity of the Alenka Luzar hydrogen-bonding model within this framework.

Paclitaxel (PCL) faces translational barriers including poor aqueous solubility (log P = 3.0) and dose-limiting toxicity. Hydrogenated soy phosphatidylcholine (HSPC) liposomes were engineered exploiting the lipid’s high phase transition temperature (Tm 52 °C) for membrane rigidity and sustained drug retention. Synthesized via thin-film hydration (HSPC:cholesterol:PCL = 7:2:0.1), nano-formulations achieved a mean diameter of 142.3 ± 8.7 nm and PDI of 0.178 ± 0.01 by dynamic light scattering, a zeta potential of − 28.4 ± 1.5 mV determined by electrophoretic light scattering, 87.6 ± 2.1

This study introduces a novel isocratic ultra-performance liquid chromatography method coupled with photodiode array and electrospray ionization mass spectrometry (ESI/MS) for the quantification of the antifungal drug Posaconazole (PCZ) and its four degradation products in tablet formulations. Employing an innovative Analytical quality by design (AQbD) approach, we established robust chromatographic conditions for precise measurement of degradation impurities resulting from forced degradation processes, such as acid/alkali hydrolysis, peroxide oxidation and thermal/photo degradation. A comprehensive risk assessment was conducted using failure mode effects analysis to identify critical analytical attributes (CAAs) and their impact on analytical target profiles (ATPs). The interactions between the identified CMAs (CMA1—retention time of PCZ and degradant peak; CMA2—resolution between degradant peaks) and ATPs were explored using a Box–Behnken Design (BBD), which led to the selection of optimal chromatographic conditions. These consisted of a mobile phase comprising 20 mM ammonium formate buffer (pH 4.2), acetonitrile, and methanol (70:18:12 v/v/v), an X‑Bridge C18 column (150 × 4.6 mm, 3.5 µm), a detection wavelength of 260 nm, a flow rate of 1.0 mL/min, and an injection volume of 5 µL. Each risk factors were reevaluated, and control on each was relinquished. The validation of the method was performed according to ICH Q2 (R2) guidelines, confirming its specificity, precision, linearity, LOQ, LOD, and accuracy. The developed method was deemed stability-indicating and suitable for routine and stability testing of Posaconazole formulations.

Dielectric measurements were performed on binary mixtures of 2- isopropoxyethanol (IPE) and Dimethyl Sulfoxide (DMSO) at various concentrations, and temperatures. The measurements were performed over a frequency range of 10 MHz to 30 GHz using Time Domain Reflectometry (TDR). The complex permittivity spectra were fitted using the Havriliak - Negami equation. The results show that the dielectric constant decreases with an increase in 2-isopropoxyethanol (IPE) concentration, reflecting a reduced ability of the system to store electrical energy. Conversely, relaxation time increases, indicating slower molecular dynamics. Positive (epsilon 0E) values suggest enhanced dipolar interactions across all concentrations, with the highest contribution observed in the composition range of VDMSO = 0.4-0.6. The negative (1/tau)E values indicate slowed dipolar relaxation, further confirming strong solute-solvent interactions. The activation enthalpy (triangle H) is highest for pure DMSO and decreases at VIPE = 0.4, indicating composition-dependent structural changes.