We analyzed the association between dietary Mn intake and obesity measured by BMI after adjustment for intake of nutrients and food groups in people with T2DM in Japan. Participants were 1567 people, 63% male, aged 30 to 89 y who were in the Japan Diabetes Clinical Data Management Study Group (JDDM), one of the largest cohorts of Japanese with diabetes. Intake of food groups was determined by a validated self-administered food frequency questionnaire based on food groups. Obesity was defined as BMI ≥25 kg/m2. Multivariate logistic regression analysis assessed the relationship between quartiles of dietary Mn intake and obesity stratified by age. Participants aged 30 to 89 y were grouped according to the following quartiles for age: 30-54 y, 55-63 y, 64-71 y, and 72-89 y. Compared to the lowest quartile (Q1) for Mn, a significant negative association between Mn and BMI was found in males for all quartiles of Mn (OR [95%CI] of Q2= 0.643 [0.424 - 0.973], Q3= 0.607 [0.374 - 0.986], Q4= 0.398 [0.218 - 0.728], p trend = 0.028) with adjustment for characteristics such as age, sex, current smoking, drinking, insulin, oral hypoglycemic agents treatment, activity, energy intake and macronutrients intake. However, statistical significance disappeared after adding total fiber as a covariate. Compared to the lowest quartile for Mn, the highest quartile of Mn was inversely associated with BMI in the younger age group (30-54 y [OR= 0.296 [0.088 - 0.996]]) even after total fiber adjustment. Multivariate analysis of food groups (rice, vegetables, soy products) that were highly correlated with Mn as covariates showed that the relationships between Mn intake and obesity were maintained (p trend for rice, vegetables, soy = <0.001, 0.187, 0.010) in all participants. In summary, higher dietary Mn intake was independently associated with a lower BMI, especially in the younger group and males. Future prospective or intervention studies are expected to confirm this result. Disclosure L.Khin: None. H.Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kyowa Kirin Co., Ltd., Taisho Pharmaceutical Holdings Co., Ltd., Ono Pharmaceutical Co., Ltd., Eisai Co., Ltd., Takeda Pharmaceutical Co., Ltd. Jddm study group: n/a. K.Fujihara: None. M.Hatta: None. Y.Takeda: None. S.Y.Morikawa: None. C.Horikawa: None. N.Kato: None. M.Kato: None. H.Maegawa: None.
Continuous-flow processing has many advantages over conventional batch processing, including high process safety, productivity, and scalability. This emerging technology expands the possibility of synthetic chemistry into new areas. Recently, many researchers in pharmaceutical companies have increasingly tried to apply continuous-flow methodologies to their manufacturing process. Here, we introduce a safe and efficient plug flow reactor system for hazardous reactions and a simple and practical packed-bed reactor system for catalytic reactions by taking advantage of flow technology. Our flow systems showed that they apply to the synthesis of various pharmaceutical intermediates in good to excellent yields and are readily scaled up while increasing the process safety and efficiency. Furthermore, we designed and installed commercial flow reactors and successfully implemented large-scale productions using the facilities under GMP condition.
Recently, DS (Directionally Solidified) and SC (Single Crystal) alloys have been widely applied for gas turbine blades instead of CC (Conventional Casting) alloys, in order to improve the creep rupture strength. The DS blade consists of several columnar grains of SC, where the growing direction of the columnar crystal is set to the direction of the centrifugal force. Because the elastic constants of the DS blade are anisotropic, the mistuning characteristics of the bladed disk consisting of the DS blades seem to be different from those of the CC blade. In this study, the resonant response and random response analysis of mistuned bladed disks consisting of the DS blades are carried out, considering the deviations of the elastic constants and the crystal angle of the DS blade. The FMM (Fundamental Mistuning Model) and the conventional modal analysis method are used to analyze the vibration response of the mistuned bladed disk. The maximum resonant response and random response of the mistuned bladed disk consisting of the DS blades are estimated by the Monte Carlo simulation combining with the response surface method. These calculated results for the DS blades are compared with those of the CC blades. From these results, it is concluded that the maximum response of the mistuned bladed disk consisting of the DS blades is the nearly same as that of the CC blades. However, in the design of the tuned blade, where the blade resonance should be avoided, it is necessary to consider that the range of the resonant frequency of the DS blade becomes wider than that of the CC blade.
