One Telecommunications (also known as One Albania) is a telecommunications company that operates in Albania, previously as Albanian Mobile Communications (AMC), and as Telekom Albania. AMC was part of the COSMOTE Group from 2000, and in 2008 joined the Deutsche Telekom group.In July 2020, Telekom Albania changed its name of registration to “One Communication”, starting the transition to a new brand (ONE).
Neutrophils and monocytes provide a first line of defense against infections as part of the innate immune system. Here we report the integrated analysis of transcriptomic and epigenetic landscapes for circulating monocytes and neutrophils with the aim to enable downstream interpretation and functional validation of key regulatory elements in health and disease. We collected RNA-seq data, ChIP-seq of six histone modifications and of DNA methylation by bisulfite sequencing at base pair resolution from up to 6 individuals per cell type. Chromatin segmentation analyses suggested that monocytes have a higher number of cell-specific enhancer regions (4-fold) compared to neutrophils. This highly plastic epigenome is likely indicative of the greater differentiation potential of monocytes into macrophages, dendritic cells and osteoclasts. In contrast, most of the neutrophil-specific features tend to be characterized by repressed chromatin, reflective of their status as terminally differentiated cells. Enhancers were the regions where most of differences in DNA methylation between cells were observed, with monocyte-specific enhancers being generally hypomethylated. Monocytes show a substantially higher gene expression levels than neutrophils, in line with epigenomic analysis revealing that gene more active elements in monocytes. Our analyses suggest that the overexpression of c-Myc in monocytes and its binding to monocyte-specific enhancers could be an important contributor to these differences. Altogether, our study provides a comprehensive epigenetic chart of chromatin states in primary human neutrophils and monocytes, thus providing a valuable resource for studying the regulation of the human innate immune system.
Background: Identifying the commonly prevailing health and nutritional disorders in school going children is essential to initiate appropriate public health measures. Materials and Methods: A cross-sectional prospective study was designed to conduct a detail physical health assessment of children studying in class 1-8 (age- 5-13 years) of 31 schools of Ahmedabad city, India between December 2011 and February 2012. Under the school health program of state government, medical history, height, weight and general physical examination findings, including dental and ophthalmic examination were recorded by qualified medical practitioners. Children with abnormal results were further investigated and treated by the subject experts. Result: Total 28,256 children were screened (boys-15,087 and girls-13,169). Mean weight and height of the children were 27.04 kg and 128.81 cm, respectively. Analysis of nutritional status of the cohort population as compared to body mass index standards revealed that 8319 (29.44%) children were underweight while only 221 (0.78%) children were either overweight or obese. The subgroup analysis of basic nutrition indices in children revealed prevalence of significant malnutrition (based on Indian Council of Medical Research standards) in children below 10 years of age. Commonly prevailing health disorders included worm infestation (42%), upper respiratory tract infection (36.39%), anemia (30.99%) dental caries (25.19%) and refractory errors (10.2%). Conclusions: Malnutrition and related health disorders are commonly prevailing childhood diseases in the urban community and can effectively be addressed by appropriate public health program.
