Anemia is less prevalent in autosomal dominant polycystic kidney disease (ADPKD) owing to preserved erythropoietin production. However, its impact on kidney prognosis remains unclear. Given sex-related differences in hemoglobin (Hb) levels, we hypothesized that the prognostic relevance of anemia may vary by sex and age. Therefore, we aimed to identify subgroup-specific risk patterns using an attribute-based cross-classification approach to support individualized anemia management in ADPKD. We analyzed 552 Japanese patients with ADPKD from a single-center cohort. The primary outcome was a ≥ 30
This study investigated the clinical outcomes of robotic-assisted unicompartmental knee arthroplasty (UKA) performed using a surface-matching kinematic technique that restores native joint morphology without alignment constraints. The primary aim was to determine the incidence and distribution of radiolucent lines (RLLs), and the secondary aim was to evaluate short-term revision rates and clinical outcomes. This retrospective cohort study reviewed 242 medial UKAs performed between November 2021 and August 2023 by the same high‑volume surgeon using a surface‑matching technique. Radiographic parameters and patient‑reported outcome measures (PROMs) obtained before and 1 year after surgery were assessed, with radiographic evaluation performed independently of the clinical outcome assessment. A cemented JOURNEY II Uni implant was used in all cases, with intraoperative surface mapping used to guide kinematic placement of components without alignment constraints. RLLs were seen in 21.9
With recent advances in chemotherapy for unresectable pancreatic ductal adenocarcinoma (PDAC) with liver metastasis (LM), attempts have been made to resect the primary tumor in patients showing favorable responses to anti-cancer treatment (so-called “conversion surgery”; CS). This study aimed to clarify the outcomes of CS for PDAC with LM in a nationwide multicenter study. This retrospective, multicenter study was conducted as a project study of the Japan Pancreas Society and included patients with PDAC with LM at initial diagnosis, diagnosed radiologically or intraoperatively (occult LM), who underwent CS after at least 4 months of chemotherapy between 2010 and 2022. Survival outcomes and prognostic factors were analyzed. 90 patients were enrolled from 31 Japanese institutions. Median duration of preoperative chemotherapy was 10.4 (range, 4.2–58.5) months, and gemcitabine plus nab-paclitaxel was the most common first-line regimen, followed by folinic acid, 5-fluorouracil, irinotecan, and oxaliplatin. Liver metastasectomy was performed in 27 patients (30
To investigate longitudinal trends in the proportion of seronegative rheumatoid arthritis (RA) and to compare clinical outcomes between seronegative and seropositive patients in a Japanese single-centre cohort. We included 4,354 RA patients with a disease duration < 4 years from the Institute of Rheumatology, Rheumatoid Arthritis cohort. Seronegativity was defined as the absence of both rheumatoid factor (RF) and anti-citrullinated peptide (CCP) antibody. We assessed the association between enrolment period and seronegativity using multivariable logistic regression. A mixed-effects model was used to compare 3-year trends in Disease Activity Score in 28 joints using erythrocyte sedimentation rate (DAS28-ESR), clinical disease activity index (CDAI), and the Japanese version of the Health Assessment Questionnaire (J-HAQ) scores between serostatus groups. The proportion of seronegative RA increased from 14.4
Background Roles of induction chemotherapy (ICT) and chemoradiotherapy (CRT) for laryngeal preservation in patients with locally advanced laryngeal cancer (LC) remain unclear. Patients and methods We enrolled 834 patients with T3N0-2M0 and T4aN0-2M0 LC registered in the Head and Neck Cancer Registry of Japan between 2011 and 2015. Oncological outcomes of total laryngectomy (TL), CRT, and ICT were evaluated. Propensity score-matching analyses (PSMA) were performed between TL and CRT, excluding ICT. Results No significant differences were observed in overall survival (OS) and disease-specific survival (DSS) among patients treated by TL, CRT, and ICT followed by TL or CRT, and among patients treated by TL and CRT in PSMA. Of note, no significant difference was observed in LCR and LRFS between TL and ICT groups. Conclusions ICT and CRT did not yield survival benefits but might contribute to laryngeal preservation without compromising survival in patients with T3-4aN0-2M0.
