Tung Wah Hospital is a hospital in Hong Kong under the Tung Wah Group of Hospitals. Located above Possession Point, at 12 Po Yan Street in Sheung Wan, it is the first hospital established in Colonial Hong Kong for the general public in the 1870s..
Long-term outcome on breast cancer surveillance in BRCA mutation carriers are limited, especially in Asian populations where uptake of preventive surgery is low. We conducted a retrospective cohort study of 722 female BRCA1 and BRCA2 mutation carriers enrolled between January 2007 and December 2024 in the Hong Kong Hereditary Breast Cancer Family Registry. Of these, 702 (97.2
Abstract Background and aims Intermittent theta burst stimulation (iTBS) is a promising for poststroke rehabilitation. To stabilize this variability and enhance the clinical benefits of iTBS, we have proposed a novel metaplasticity-elicited priming paradigm involving an inhibitory session using continuous theta burst stimulation (cTBS) followed by an excitatory iTBS session (priming iTBS; Zhang et al., 2022, Stroke). While preceding cTBS at 70% RMT can lower the threshold for LTP induction, it may also suppress overall corticomotor excitability, potentially counteracting the subsequent iTBS (Zhang et al., 2025, Brain Stimulation). Here we aim to determine whether a low-intensity priming iTBS to the ipsilesional motor cortex produces superior improvements in upper-extremity recovery and cortical excitability compared to other protocols in ischemic stroke patients. Methods Participants are randomized to one of four 4-week interventions: low-intensity priming (55% RMT cTBS+iTBS); conventional priming (70% RMT cTBS+iTBS); nonpriming (sham cTBS+iTBS); and sham. All receive 60-minute motor training post-stimulation. The primary outcome is the change in the Fugl-Meyer-Assessment–Upper Extremity (FMA-UE). Secondary outcomes include transcranial-magnetic-stimulation-evoked potentials in concurrent TMS-EEG and upper-extremity functional measures. Results Of 124 planned participants, 24 have completed the intervention. Preliminary FMA-UE analysis finds that the low-intensity priming iTBS improves the most numerically, and all active stimulation show greater gains than the sham stimulation - a trend that is consistent across other functional measures of the upper-extremity. Neurophysiological data will be presented at the conference. This trial is the first to investigate the impact of intensity within a metaplasticity-induced priming protocol for poststroke rehabilitation. Conflict of interest None
Patients undergoing maintenance hemodialysis (MHD) carry a substantial burden of cardiovascular disease and mortality. Accessible prognostic biomarkers are needed to improve risk stratification. We examined the association between the systemic inflammatory response index (SIRI) and clinical outcomes, and compared SIRI with established inflammatory markers, including the neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR), as well as conventional clinical parameters such as C-reactive protein (CRP), white blood cell count, and serum albumin. A retrospective analysis was conducted in a cohort of 221 prevalent hemodialysis patients enrolled at Dongguan Tung Wah Hospital between January and July 2019. Patients were categorized into tertiles based on SIRI for baseline comparison. Associations between SIRI (modeled as a continuous variable) and the risks of cardiovascular events and all-cause mortality were assessed using Cox proportional hazards models, Kaplan–Meier survival curves, and restricted cubic spline analyses. During a median follow-up period of 28 months, a total of 30 MHD patients (13.6
